Sana Ayromlou

Fatemeh Tavakoli, D. B. Emerson, Sana Ayromlou et al.

Federated learning (FL) is increasingly being recognized as a key approach to overcoming the data silos that so frequently obstruct the training and deployment of machine-learning models in clinical settings. This work contributes to a growing body of FL research specifically focused on clinical applications along three important directions. First, we expand the FLamby benchmark (du Terrail et al., 2022a) to include a comprehensive evaluation of personalized FL methods and demonstrate substantive performance improvements over the original results. Next, we advocate for a comprehensive checkpointing and evaluation framework for FL to reflect practical settings and provide multiple comparison baselines. To this end, an open-source library aimed at making FL experimentation simpler and more reproducible is released. Finally, we propose an important ablation of PerFCL (Zhang et al., 2022). This ablation results in a natural extension of FENDA (Kim et al., 2016) to the FL setting. Experiments conducted on the FLamby benchmark and GEMINI datasets (Verma et al., 2017) show that the proposed approach is robust to heterogeneous clinical data and often outperforms existing global and personalized FL techniques, including PerFCL.

Sana Ayromlou, Purang Abolmaesumi, Teresa Tsang et al.

Standard deep learning-based classification approaches require collecting all samples from all classes in advance and are trained offline. This paradigm may not be practical in real-world clinical applications, where new classes are incrementally introduced through the addition of new data. Class incremental learning is a strategy allowing learning from such data. However, a major challenge is catastrophic forgetting, i.e., performance degradation on previous classes when adapting a trained model to new data. Prior methodologies to alleviate this challenge save a portion of training data require perpetual storage of such data that may introduce privacy issues. Here, we propose a novel data-free class incremental learning framework that first synthesizes data from the model trained on previous classes to generate a \ours. Subsequently, it updates the model by combining the synthesized data with new class data. Furthermore, we incorporate a cosine normalized Cross-entropy loss to mitigate the adverse effects of the imbalance, a margin loss to increase separation among previous classes and new ones, and an intra-domain contrastive loss to generalize the model trained on the synthesized data to real data. We compare our proposed framework with state-of-the-art methods in class incremental learning, where we demonstrate improvement in accuracy for the classification of 11,062 echocardiography cine series of patients.

Masoumeh Shafieinejad, Xi He, Mahshid Alinoori et al.

Synthetic data is often perceived as a silver-bullet solution to data anonymization and privacy-preserving data publishing. Drawn from generative models like diffusion models, synthetic data is expected to preserve the statistical properties of the original dataset while remaining resilient to privacy attacks. Recent developments of diffusion models have been effective on a wide range of data types, but their privacy resilience, particularly for tabular formats, remains largely unexplored. MIDST challenge sought a quantitative evaluation of the privacy gain of synthetic tabular data generated by diffusion models, with a specific focus on its resistance to membership inference attacks (MIAs). Given the heterogeneity and complexity of tabular data, multiple target models were explored for MIAs, including diffusion models for single tables of mixed data types and multi-relational tables with interconnected constraints. MIDST inspired the development of novel black-box and white-box MIAs tailored to these target diffusion models as a key outcome, enabling a comprehensive evaluation of their privacy efficacy. The MIDST GitHub repository is available at https://github.com/VectorInstitute/MIDST

Mohammadhossein Bahari, Vahid Zehtab, Sadegh Khorasani et al.

Anticipating motions of vehicles in a scene is an essential problem for safe autonomous driving systems. To this end, the comprehension of the scene's infrastructure is often the main clue for predicting future trajectories. Most of the proposed approaches represent the scene with a rasterized format and some of the more recent approaches leverage custom vectorized formats. In contrast, we propose representing the scene's information by employing Scalable Vector Graphics (SVG). SVG is a well-established format that matches the problem of trajectory prediction better than rasterized formats while being more general than arbitrary vectorized formats. SVG has the potential to provide the convenience and generality of raster-based solutions if coupled with a powerful tool such as CNNs, for which we introduce SVG-Net. SVG-Net is a Transformer-based Neural Network that can effectively capture the scene's information from SVG inputs. Thanks to the self-attention mechanism in its Transformers, SVG-Net can also adequately apprehend relations amongst the scene and the agents. We demonstrate SVG-Net's effectiveness by evaluating its performance on the publicly available Argoverse forecasting dataset. Finally, we illustrate how, by using SVG, one can benefit from datasets and advancements in other research fronts that also utilize the same input format. Our code is available at https://vita-epfl.github.io/SVGNet/.

Atrin Arya, Sana Ayromlou, Armin Saadat et al.

Standard deep learning-based classification approaches may not always be practical in real-world clinical applications, as they require a centralized collection of all samples. Federated learning (FL) provides a paradigm that can learn from distributed datasets across clients without requiring them to share data, which can help mitigate privacy and data ownership issues. In FL, sub-optimal convergence caused by data heterogeneity is common among data from different health centers due to the variety in data collection protocols and patient demographics across centers. Through experimentation in this study, we show that data heterogeneity leads to the phenomenon of catastrophic forgetting during local training. We propose FedImpres which alleviates catastrophic forgetting by restoring synthetic data that represents the global information as federated impression. To achieve this, we distill the global model resulting from each communication round. Subsequently, we use the synthetic data alongside the local data to enhance the generalization of local training. Extensive experiments show that the proposed method achieves state-of-the-art performance on both the BloodMNIST and Retina datasets, which contain label imbalance and domain shift, with an improvement in classification accuracy of up to 20%.

Sana Ayromlou, Vahid Reza Khazaie, Fereshteh Forghani et al.

The rapid advancement in self-supervised representation learning has highlighted its potential to leverage unlabeled data for learning rich visual representations. However, the existing techniques, particularly those employing different augmentations of the same image, often rely on a limited set of simple transformations that cannot fully capture variations in the real world. This constrains the diversity and quality of samples, which leads to sub-optimal representations. In this paper, we introduce a framework that enriches the self-supervised learning (SSL) paradigm by utilizing generative models to produce semantically consistent image augmentations. By directly conditioning generative models on a source image, our method enables the generation of diverse augmentations while maintaining the semantics of the source image, thus offering a richer set of data for SSL. Our extensive experimental results on various joint-embedding SSL techniques demonstrate that our framework significantly enhances the quality of learned visual representations by up to 10\% Top-1 accuracy in downstream tasks. This research demonstrates that incorporating generative models into the joint-embedding SSL workflow opens new avenues for exploring the potential of synthetic data. This development paves the way for more robust and versatile representation learning techniques.

Sana Ayromlou, Fatemeh Tavakoli, D. B. Emerson

Federated learning (FL) is an effective and widely used approach to training deep learning models on decentralized datasets held by distinct clients. FL also strengthens both security and privacy protections for training data. Common challenges associated with statistical heterogeneity between distributed datasets have spurred significant interest in personalized FL (pFL) methods, where models combine aspects of global learning with local modeling specific to each client's unique characteristics. This work investigates the efficacy of theoretically supported, adaptive MMD measures in pFL, primarily focusing on the Ditto framework, a state-of-the-art technique for distributed data heterogeneity. The use of such measures significantly improves model performance across a variety of tasks, especially those with pronounced feature heterogeneity. Additional experiments demonstrate that such measures are directly applicable to other pFL techniques and yield similar improvements across a number of datasets. Finally, the results motivate the use of constraints tailored to the various kinds of heterogeneity expected in FL systems.

Sana Ayromlou, Teresa Tsang, Purang Abolmaesumi et al.

In real-world clinical settings, traditional deep learning-based classification methods struggle with diagnosing newly introduced disease types because they require samples from all disease classes for offline training. Class incremental learning offers a promising solution by adapting a deep network trained on specific disease classes to handle new diseases. However, catastrophic forgetting occurs, decreasing the performance of earlier classes when adapting the model to new data. Prior proposed methodologies to overcome this require perpetual storage of previous samples, posing potential practical concerns regarding privacy and storage regulations in healthcare. To this end, we propose a novel data-free class incremental learning framework that utilizes data synthesis on learned classes instead of data storage from previous classes. Our key contributions include acquiring synthetic data known as Continual Class-Specific Impression (CCSI) for previously inaccessible trained classes and presenting a methodology to effectively utilize this data for updating networks when introducing new classes. We obtain CCSI by employing data inversion over gradients of the trained classification model on previous classes starting from the mean image of each class inspired by common landmarks shared among medical images and utilizing continual normalization layers statistics as a regularizer in this pixel-wise optimization process. Subsequently, we update the network by combining the synthesized data with new class data and incorporate several losses, including an intra-domain contrastive loss to generalize the deep network trained on the synthesized data to real data, a margin loss to increase separation among previous classes and new ones, and a cosine-normalized cross-entropy loss to alleviate the adverse effects of imbalanced distributions in training data.

Reza Shirkavand, Sana Ayromlou, Soroush Farghadani et al.

Early detection of dementia through specific biomarkers in MR images plays a critical role in developing support strategies proactively. Fazekas scale facilitates an accurate quantitative assessment of the severity of white matter lesions and hence the disease. Imaging Biomarkers of dementia are multiple and comprehensive documentation of them is time-consuming. Therefore, any effort to automatically extract these biomarkers will be of clinical value while reducing inter-rater discrepancies. To tackle this problem, we propose to classify the disease severity based on the Fazekas scale through the visual biomarkers, namely the Periventricular White Matter (PVWM) and the Deep White Matter (DWM) changes, in the real-world setting of thick-slice MRI. Small training sample size and weak supervision in form of assigning severity labels to the whole MRI stack are among the main challenges. To combat the mentioned issues, we have developed a deep learning pipeline that employs self-supervised representation learning, multiple instance learning, and appropriate pre-processing steps. We use pretext tasks such as non-linear transformation, local shuffling, in- and out-painting for self-supervised learning of useful features in this domain. Furthermore, an attention model is used to determine the relevance of each MRI slice for predicting the Fazekas scale in an unsupervised manner. We show the significant superiority of our method in distinguishing different classes of dementia compared to state-of-the-art methods in our mentioned setting, which improves the macro averaged F1-score of state-of-the-art from 61% to 76% in PVWM, and from 58% to 69.2% in DWM.