Daniel Acosta-Soba

Daniel Acosta-Soba, Francisco Guillén-González, J. Rafael Rodríguez-Galván

In this work, we develop a structure-preserving numerical scheme for a Cahn-Hilliard-Darcy model that describes tumor growth in a fluid-saturated porous medium. First, we derive a physically consistent model from the general framework proposed in [29] that guarantees mass conservation and pointwise bounds on the phase-field and nutrient variables, with a decreasing energy law. The resulting model couples the evolution of tumor cells via a Cahn-Hilliard equation with a diffusion equation for the nutrients thro chemotactic interactions and extends the model in [1] by introducing the effect of a surrounding fluid described by Darcy's law. Subsequently, we propose a fully discrete scheme that combines an upwind discontinuous Galerkin method in space and a convex splitting strategy in time, which inherits the fundamental properties of the continuous model: mass conservation, pointwise bounds and discrete energy law. Our theoretical analysis is accompanied by numerical experiments that demonstrate the robustness of the proposed scheme and show the influence of the surrounding fluid on the tumor evolution.

Daniel Acosta-Soba, Alessandro Columbu, J. Rafael Rodríguez-Galván

In this work we present a novel linear and positivity preserving upwind discontinuous Galerkin (DG) approximation of a class of chemotaxis models with damping gradient nonlinearities. In particular, both a local and a nonlocal model including nonlinear diffusion, chemoattraction, chemorepulsion and logistic growth are considered. Some numerical experiments in the context of chemotactic collapse are presented, whose results are in accordance with the previous analysis of the approximation and show how the blow-up can be prevented by means of the damping gradient term.