Mingjing Li

Linshanshan Wang, Mengyan Li, Zongqi Xia et al.

Electronic Health Records (EHR) offer rich real-world data for personalized medicine, providing insights into disease progression, treatment responses, and patient outcomes. However, their sparsity, heterogeneity, and high dimensionality make them difficult to model, while the lack of standardized ground truth further complicates predictive modeling. To address these challenges, we propose SCORE, a semi-supervised representation learning framework that captures multi-domain disease profiles through patient embeddings. SCORE employs a Poisson-Adapted Latent factor Mixture (PALM) Model with pre-trained code embeddings to characterize codified features and extract meaningful patient phenotypes and embeddings. To handle the computational challenges of large-scale data, it introduces a hybrid Expectation-Maximization (EM) and Gaussian Variational Approximation (GVA) algorithm, leveraging limited labeled data to refine estimates on a vast pool of unlabeled samples. We theoretically establish the convergence of this hybrid approach, quantify GVA errors, and derive SCORE's error rate under diverging embedding dimensions. Our analysis shows that incorporating unlabeled data enhances accuracy and reduces sensitivity to label scarcity. Extensive simulations confirm SCORE's superior finite-sample performance over existing methods. Finally, we apply SCORE to predict disability status for patients with multiple sclerosis (MS) using partially labeled EHR data, demonstrating that it produces more informative and predictive patient embeddings for multiple MS-related conditions compared to existing approaches.

Minda Li, Bhaskar Krishnamachari

ChatGPT and other large language models (LLMs) promise to revolutionize software development by automatically generating code from program specifications. We assess the performance of ChatGPT's GPT-3.5-turbo model on LeetCode, a popular platform with algorithmic coding challenges for technical interview practice, across three difficulty levels: easy, medium, and hard. We test three main hypotheses. First, ChatGPT solves fewer problems as difficulty rises (Hypothesis 1). Second, prompt engineering improves ChatGPT's performance, with greater gains on easier problems and diminishing returns on harder ones (Hypothesis 2). Third, ChatGPT performs better in popular languages like Python, Java, and C++ than in less common ones like Elixir, Erlang, and Racket (Hypothesis 3). To investigate these hypotheses, we conduct automated experiments using Python scripts to generate prompts that instruct ChatGPT to create Python solutions. These solutions are stored and manually submitted on LeetCode to check their correctness. For Hypothesis 1, results show the GPT-3.5-turbo model successfully solves 92% of easy, 79% of medium, and 51% of hard problems. For Hypothesis 2, prompt engineering yields improvements: 14-29% for Chain of Thought Prompting, 38-60% by providing failed test cases in a second feedback prompt, and 33-58% by switching to GPT-4. From a random subset of problems ChatGPT solved in Python, it also solved 78% in Java, 50% in C++, and none in Elixir, Erlang, or Racket. These findings generally validate all three hypotheses.

Lu Han, Mengyan Li, Jiping Qiang et al.

Heterogeneous data, which encompass both numerical financial variables and textual records, present substantial challenges for credit monitoring. To address this issue, we propose Advanced Spectral Clustering (ASC), a method that integrates financial and textual similarities through an optimized weight parameter and selects eigenvectors using a novel eigenvalue-silhouette optimization approach. Evaluated on a dataset comprising 1,428 small and medium-sized enterprises (SMEs), ASC achieves a Silhouette score that is 18% higher than that of a single-type data baseline method. Furthermore, the resulting clusters offer actionable insights; for instance, 51% of low-risk firms are found to include the term 'social recruitment' in their textual records. The robustness of ASC is confirmed across multiple clustering algorithms, including k-means, k-medians, and k-medoids, with ΔIntra/Inter < 0.13 and ΔSilhouette Coefficient < 0.02. By bridging spectral clustering theory with heterogeneous data applications, ASC enables the identification of meaningful clusters, such as recruitment-focused SMEs exhibiting a 30% lower default risk, thereby supporting more targeted and effective credit interventions.