Hanqing Yang

Bing Xue, Ahmed Sameh Said, Ziqi Xu et al.

Extracorporeal membrane oxygenation (ECMO) is an essential life-supporting modality for COVID-19 patients who are refractory to conventional therapies. However, the proper treatment decision has been the subject of significant debate and it remains controversial about who benefits from this scarcely available and technically complex treatment option. To support clinical decisions, it is a critical need to predict the treatment need and the potential treatment and no-treatment responses. Targeting this clinical challenge, we propose Treatment Variational AutoEncoder (TVAE), a novel approach for individualized treatment analysis. TVAE is specifically designed to address the modeling challenges like ECMO with strong treatment selection bias and scarce treatment cases. TVAE conceptualizes the treatment decision as a multi-scale problem. We model a patient's potential treatment assignment and the factual and counterfactual outcomes as part of their intrinsic characteristics that can be represented by a deep latent variable model. The factual and counterfactual prediction errors are alleviated via a reconstruction regularization scheme together with semi-supervision, and the selection bias and the scarcity of treatment cases are mitigated by the disentangled and distribution-matched latent space and the label-balancing generative strategy. We evaluate TVAE on two real-world COVID-19 datasets: an international dataset collected from 1651 hospitals across 63 countries, and a institutional dataset collected from 15 hospitals. The results show that TVAE outperforms state-of-the-art treatment effect models in predicting both the propensity scores and factual outcomes on heterogeneous COVID-19 datasets. Additional experiments also show TVAE outperforms the best existing models in individual treatment effect estimation on the synthesized IHDP benchmark dataset.

Narjes Nourzad, Hanqing Yang, Shiyu Chen et al.

Cooperative multi-agent planning requires agents to make joint decisions with partial information and limited communication. Coordination at the trajectory level often fails, as small deviations in timing or movement cascade into conflicts. Symbolic planning mitigates this challenge by raising the level of abstraction and providing a minimal vocabulary of actions that enable synchronization and collective progress. We present DR. WELL, a decentralized neurosymbolic framework for cooperative multi-agent planning. Cooperation unfolds through a two-phase negotiation protocol: agents first propose candidate roles with reasoning and then commit to a joint allocation under consensus and environment constraints. After commitment, each agent independently generates and executes a symbolic plan for its role without revealing detailed trajectories. Plans are grounded in execution outcomes via a shared world model that encodes the current state and is updated as agents act. By reasoning over symbolic plans rather than raw trajectories, DR. WELL avoids brittle step-level alignment and enables higher-level operations that are reusable, synchronizable, and interpretable. Experiments on cooperative block-push tasks show that agents adapt across episodes, with the dynamic world model capturing reusable patterns and improving task completion rates and efficiency. Experiments on cooperative block-push tasks show that our dynamic world model improves task completion and efficiency through negotiation and self-refinement, trading a time overhead for evolving, more efficient collaboration strategies.

Hanqing Yang, Jingdi Chen, Marie Siew et al.

Developing intelligent agents for long-term cooperation in dynamic open-world scenarios is a major challenge in multi-agent systems. Traditional Multi-agent Reinforcement Learning (MARL) frameworks like centralized training decentralized execution (CTDE) struggle with scalability and flexibility. They require centralized long-term planning, which is difficult without custom reward functions, and face challenges in processing multi-modal data. CTDE approaches also assume fixed cooperation strategies, making them impractical in dynamic environments where agents need to adapt and plan independently. To address decentralized multi-agent cooperation, we propose Decentralized Adaptive Knowledge Graph Memory and Structured Communication System (DAMCS) in a novel Multi-agent Crafter environment. Our generative agents, powered by Large Language Models (LLMs), are more scalable than traditional MARL agents by leveraging external knowledge and language for long-term planning and reasoning. Instead of fully sharing information from all past experiences, DAMCS introduces a multi-modal memory system organized as a hierarchical knowledge graph and a structured communication protocol to optimize agent cooperation. This allows agents to reason from past interactions and share relevant information efficiently. Experiments on novel multi-agent open-world tasks show that DAMCS outperforms both MARL and LLM baselines in task efficiency and collaboration. Compared to single-agent scenarios, the two-agent scenario achieves the same goal with 63% fewer steps, and the six-agent scenario with 74% fewer steps, highlighting the importance of adaptive memory and structured communication in achieving long-term goals. We publicly release our project at: https://happyeureka.github.io/damcs.