Qun Jin

Ruilong Dan, Yunxiang Li, Yijie Wang et al.

Precise and rapid categorization of images in the B-scan ultrasound modality is vital for diagnosing ocular diseases. Nevertheless, distinguishing various diseases in ultrasound still challenges experienced ophthalmologists. Thus a novel contrastive disentangled network (CDNet) is developed in this work, aiming to tackle the fine-grained image categorization (FGIC) challenges of ocular abnormalities in ultrasound images, including intraocular tumor (IOT), retinal detachment (RD), posterior scleral staphyloma (PSS), and vitreous hemorrhage (VH). Three essential components of CDNet are the weakly-supervised lesion localization module (WSLL), contrastive multi-zoom (CMZ) strategy, and hyperspherical contrastive disentangled loss (HCD-Loss), respectively. These components facilitate feature disentanglement for fine-grained recognition in both the input and output aspects. The proposed CDNet is validated on our ZJU Ocular Ultrasound Dataset (ZJUOUSD), consisting of 5213 samples. Furthermore, the generalization ability of CDNet is validated on two public and widely-used chest X-ray FGIC benchmarks. Quantitative and qualitative results demonstrate the efficacy of our proposed CDNet, which achieves state-of-the-art performance in the FGIC task. Code is available at: https://github.com/ZeroOneGame/CDNet-for-OUS-FGIC .

Jingxiong Li, Yaqi Wang, Shuai Wang et al.

Coronavirus disease 2019 (COVID-19) is one of the most destructive pandemic after millennium, forcing the world to tackle a health crisis. Automated lung infections classification using chest X-ray (CXR) images could strengthen diagnostic capability when handling COVID-19. However, classifying COVID-19 from pneumonia cases using CXR image is a difficult task because of shared spatial characteristics, high feature variation and contrast diversity between cases. Moreover, massive data collection is impractical for a newly emerged disease, which limited the performance of data thirsty deep learning models. To address these challenges, Multiscale Attention Guided deep network with Soft Distance regularization (MAG-SD) is proposed to automatically classify COVID-19 from pneumonia CXR images. In MAG-SD, MA-Net is used to produce prediction vector and attention from multiscale feature maps. To improve the robustness of trained model and relieve the shortage of training data, attention guided augmentations along with a soft distance regularization are posed, which aims at generating meaningful augmentations and reduce noise. Our multiscale attention model achieves better classification performance on our pneumonia CXR image dataset. Plentiful experiments are proposed for MAG-SD which demonstrates its unique advantage in pneumonia classification over cutting-edge models. The code is available at https://github.com/JasonLeeGHub/MAG-SD.

Ou Deng, Qun Jin

Addressing missing data in complex datasets including electronic health records (EHR) is critical for ensuring accurate analysis and decision-making in healthcare. This paper proposes dynamically adaptable structural equation modeling (SEM) using a self-attention method (SESA), an approach to data imputation in EHR. SESA innovates beyond traditional SEM-based methods by incorporating self-attention mechanisms, thereby enhancing model adaptability and accuracy across diverse EHR datasets. Such enhancement allows SESA to dynamically adjust and optimize imputation and overcome the limitations of static SEM frameworks. Our experimental analyses demonstrate the achievement of robust predictive SESA performance for effectively handling missing data in EHR. Moreover, the SESA architecture not only rectifies potential mis-specifications in SEM but also synergizes with causal discovery algorithms to refine its imputation logic based on underlying data structures. Such features highlight its capabilities and broadening applicational potential in EHR data analysis and beyond, marking a reasonable leap forward in the field of data imputation.

Ou Deng, Shoji Nishimura, Atsushi Ogihara et al.

This study proposes Evolutionary Causal Discovery (ECD) for causal discovery that tailors response variables, predictor variables, and corresponding operators to research datasets. Utilizing genetic programming for variable relationship parsing, the method proceeds with the Relative Impact Stratification (RIS) algorithm to assess the relative impact of predictor variables on the response variable, facilitating expression simplification and enhancing the interpretability of variable relationships. ECD proposes an expression tree to visualize the RIS results, offering a differentiated depiction of unknown causal relationships compared to conventional causal discovery. The ECD method represents an evolution and augmentation of existing causal discovery methods, providing an interpretable approach for analyzing variable relationships in complex systems, particularly in healthcare settings with Electronic Health Record (EHR) data. Experiments on both synthetic and real-world EHR datasets demonstrate the efficacy of ECD in uncovering patterns and mechanisms among variables, maintaining high accuracy and stability across different noise levels. On the real-world EHR dataset, ECD reveals the intricate relationships between the response variable and other predictive variables, aligning with the results of structural equation modeling and shapley additive explanations analyses.

Ou Deng, Ruichen Cong, Jianting Xu et al.

Symbolic regression promises readable equations but struggles to encode unit-aware thresholds and conditional logic. We propose logistic-gated operators (LGO) -- differentiable gates with learnable location and steepness -- embedded as typed primitives and mapped back to physical units for audit. Across two primary health datasets (ICU, NHANES), the hard-gate variant recovers clinically plausible cut-points: 71% (5/7) of assessed thresholds fall within 10% of guideline anchors and 100% within 20%, while using far fewer gates than the soft variant (ICU median 4.0 vs 10.0; NHANES 5.0 vs 12.5), and remaining within the competitive accuracy envelope of strong SR baselines. On predominantly smooth tasks, gates are pruned, preserving parsimony. The result is compact symbolic equations with explicit, unit-aware thresholds that can be audited against clinical anchors -- turning interpretability from a post-hoc explanation into a modeling constraint and equipping symbolic regression with a practical calculus for regime switching and governance-ready deployment.

Yunxiang Li, Jingxiong Li, Ruilong Dan et al.

Accurate segmentation is a crucial step in medical image analysis and applying supervised machine learning to segment the organs or lesions has been substantiated effective. However, it is costly to perform data annotation that provides ground truth labels for training the supervised algorithms, and the high variance of data that comes from different domains tends to severely degrade system performance over cross-site or cross-modality datasets. To mitigate this problem, a novel unsupervised domain adaptation (UDA) method named dispensed Transformer network (DTNet) is introduced in this paper. Our novel DTNet contains three modules. First, a dispensed residual transformer block is designed, which realizes global attention by dispensed interleaving operation and deals with the excessive computational cost and GPU memory usage of the Transformer. Second, a multi-scale consistency regularization is proposed to alleviate the loss of details in the low-resolution output for better feature alignment. Finally, a feature ranking discriminator is introduced to automatically assign different weights to domain-gap features to lessen the feature distribution distance, reducing the performance shift of two domains. The proposed method is evaluated on large fluorescein angiography (FA) retinal nonperfusion (RNP) cross-site dataset with 676 images and a wide used cross-modality dataset from the MM-WHS challenge. Extensive results demonstrate that our proposed network achieves the best performance in comparison with several state-of-the-art techniques.

Yunxiang Li, Guodong Zeng, Yifan Zhang et al.

Accurate evaluation of the treatment result on X-ray images is a significant and challenging step in root canal therapy since the incorrect interpretation of the therapy results will hamper timely follow-up which is crucial to the patients' treatment outcome. Nowadays, the evaluation is performed in a manual manner, which is time-consuming, subjective, and error-prone. In this paper, we aim to automate this process by leveraging the advances in computer vision and artificial intelligence, to provide an objective and accurate method for root canal therapy result assessment. A novel anatomy-guided multi-branch Transformer (AGMB-Transformer) network is proposed, which first extracts a set of anatomy features and then uses them to guide a multi-branch Transformer network for evaluation. Specifically, we design a polynomial curve fitting segmentation strategy with the help of landmark detection to extract the anatomy features. Moreover, a branch fusion module and a multi-branch structure including our progressive Transformer and Group Multi-Head Self-Attention (GMHSA) are designed to focus on both global and local features for an accurate diagnosis. To facilitate the research, we have collected a large-scale root canal therapy evaluation dataset with 245 root canal therapy X-ray images, and the experiment results show that our AGMB-Transformer can improve the diagnosis accuracy from 57.96% to 90.20% compared with the baseline network. The proposed AGMB-Transformer can achieve a highly accurate evaluation of root canal therapy. To our best knowledge, our work is the first to perform automatic root canal therapy evaluation and has important clinical value to reduce the workload of endodontists.

Yunxiang Li, Yifan Zhang, Yaqi Wang et al.

As the most economical and routine auxiliary examination in the diagnosis of root canal treatment, oral X-ray has been widely used by stomatologists. It is still challenging to segment the tooth root with a blurry boundary for the traditional image segmentation method. To this end, we propose a model for high-resolution segmentation based on polynomial curve fitting with landmark detection (HS-PCL). It is based on detecting multiple landmarks evenly distributed on the edge of the tooth root to fit a smooth polynomial curve as the segmentation of the tooth root, thereby solving the problem of fuzzy edge. In our model, a maximum number of the shortest distances algorithm (MNSDA) is proposed to automatically reduce the negative influence of the wrong landmarks which are detected incorrectly and deviate from the tooth root on the fitting result. Our numerical experiments demonstrate that the proposed approach not only reduces Hausdorff95 (HD95) by 33.9% and Average Surface Distance (ASD) by 42.1% compared with the state-of-the-art method, but it also achieves excellent results on the minute quantity of datasets, which greatly improves the feasibility of automatic root canal therapy evaluation by medical image computing.