Zhongwei Wan

Chaofan Tao, Qian Liu, Longxu Dou et al.

Research on scaling large language models (LLMs) has primarily focused on model parameters and training data size, overlooking the role of vocabulary size. We investigate how vocabulary size impacts LLM scaling laws by training models ranging from 33M to 3B parameters on up to 500B characters with various vocabulary configurations. We propose three complementary approaches for predicting the compute-optimal vocabulary size: IsoFLOPs analysis, derivative estimation, and parametric fit of the loss function. Our approaches converge on the conclusion that the optimal vocabulary size depends on the compute budget, with larger models requiring larger vocabularies. Most LLMs, however, use insufficient vocabulary sizes. For example, we predict that the optimal vocabulary size of Llama2-70B should have been at least 216K, 7 times larger than its vocabulary of 32K. We validate our predictions empirically by training models with 3B parameters across different FLOPs budgets. Adopting our predicted optimal vocabulary size consistently improves downstream performance over commonly used vocabulary sizes. By increasing the vocabulary size from the conventional 32K to 43K, we improve performance on ARC-Challenge from 29.1 to 32.0 with the same 2.3e21 FLOPs. Our work highlights the importance of jointly considering tokenization and model scaling for efficient pre-training. The code and demo are available at https://github.com/sail-sg/scaling-with-vocab and https://hf.co/spaces/sail/scaling-with-vocab-demo.

Jinfa Huang, Jinsheng Pan, Zhongwei Wan et al.

Recent advances show that two-stream approaches have achieved outstanding performance in hateful meme detection. However, hateful memes constantly evolve as new memes emerge by fusing progressive cultural ideas, making existing methods obsolete or ineffective. In this work, we explore the potential of Large Multimodal Models (LMMs) for hateful meme detection. To this end, we propose Evolver, which incorporates LMMs via Chain-of-Evolution (CoE) Prompting, by integrating the evolution attribute and in-context information of memes. Specifically, Evolver simulates the evolving and expressing process of memes and reasons through LMMs in a step-by-step manner. First, an evolutionary pair mining module retrieves the top-k most similar memes in the external curated meme set with the input meme. Second, an evolutionary information extractor is designed to summarize the semantic regularities between the paired memes for prompting. Finally, a contextual relevance amplifier enhances the in-context hatefulness information to boost the search for evolutionary processes. Extensive experiments on public FHM, MAMI, and HarM datasets show that CoE prompting can be incorporated into existing LMMs to improve their performance. More encouragingly, it can serve as an interpretive tool to promote the understanding of the evolution of social memes. [Homepage] (https://github.com/inFaaa/Evolver)

Zhongwei Wan, Yichun Yin, Wei Zhang et al. · tsinghua

Recently, domain-specific PLMs have been proposed to boost the task performance of specific domains (e.g., biomedical and computer science) by continuing to pre-train general PLMs with domain-specific corpora. However, this Domain-Adaptive Pre-Training (DAPT; Gururangan et al. (2020)) tends to forget the previous general knowledge acquired by general PLMs, which leads to a catastrophic forgetting phenomenon and sub-optimal performance. To alleviate this problem, we propose a new framework of General Memory Augmented Pre-trained Language Model (G-MAP), which augments the domain-specific PLM by a memory representation built from the frozen general PLM without losing any general knowledge. Specifically, we propose a new memory-augmented layer, and based on it, different augmented strategies are explored to build the memory representation and then adaptively fuse it into the domain-specific PLM. We demonstrate the effectiveness of G-MAP on various domains (biomedical and computer science publications, news, and reviews) and different kinds (text classification, QA, NER) of tasks, and the extensive results show that the proposed G-MAP can achieve SOTA results on all tasks.

Che Liu, Zhongwei Wan, Sibo Cheng et al.

In the domain of cardiovascular healthcare, the Electrocardiogram (ECG) serves as a critical, non-invasive diagnostic tool. Although recent strides in self-supervised learning (SSL) have been promising for ECG representation learning, these techniques often require annotated samples and struggle with classes not present in the fine-tuning stages. To address these limitations, we introduce ECG-Text Pre-training (ETP), an innovative framework designed to learn cross-modal representations that link ECG signals with textual reports. For the first time, this framework leverages the zero-shot classification task in the ECG domain. ETP employs an ECG encoder along with a pre-trained language model to align ECG signals with their corresponding textual reports. The proposed framework excels in both linear evaluation and zero-shot classification tasks, as demonstrated on the PTB-XL and CPSC2018 datasets, showcasing its ability for robust and generalizable cross-modal ECG feature learning.

Ruiyao Liu, Hui Shen, Ping Zhang et al.

Modern generative models have demonstrated the ability to solve challenging mathematical problems. In many real-world settings, however, mathematical solutions must be expressed visually through diagrams, plots, geometric constructions, and structured symbolic layouts, where correctness depends on precise visual composition. This naturally raises the question of whether generative models can still do so when the answer must be rendered visually rather than written in text? To study this problem, we introduce MathGen, a rigorous benchmark of 900 problems spanning seven core domains, each paired with an executable verifier under a Script-as-a-Judge protocol for deterministic and objective evaluation. Experiments on representative open-source and proprietary text-to-image models show that mathematical fidelity remains a major bottleneck: even the best closed-source model reaches only 42.0% overall accuracy, while open-source models achieve just ~ 1-11%, often near 0% on structured tasks. Overall, current T2I models remain far from competent at even elementary mathematical visual generation.

Hui Shen, Zhongwei Wan, Xin Wang et al.

Mamba and Vision Mamba (Vim) models have shown their potential as an alternative to methods based on Transformer architecture. This work introduces Fast Mamba for Vision (Famba-V), a cross-layer token fusion technique to enhance the training efficiency of Vim models. The key idea of Famba-V is to identify and fuse similar tokens across different Vim layers based on a suit of cross-layer strategies instead of simply applying token fusion uniformly across all the layers that existing works propose. We evaluate the performance of Famba-V on CIFAR-100. Our results show that Famba-V is able to enhance the training efficiency of Vim models by reducing both training time and peak memory usage during training. Moreover, the proposed cross-layer strategies allow Famba-V to deliver superior accuracy-efficiency trade-offs. These results all together demonstrate Famba-V as a promising efficiency enhancement technique for Vim models.

Zhongwei Wan, Xin Wang, Che Liu et al.

Large Language Models (LLMs) have demonstrated remarkable capabilities in important tasks such as natural language understanding and language generation, and thus have the potential to make a substantial impact on our society. Such capabilities, however, come with the considerable resources they demand, highlighting the strong need to develop effective techniques for addressing their efficiency challenges. In this survey, we provide a systematic and comprehensive review of efficient LLMs research. We organize the literature in a taxonomy consisting of three main categories, covering distinct yet interconnected efficient LLMs topics from model-centric, data-centric, and framework-centric perspective, respectively. We have also created a GitHub repository where we organize the papers featured in this survey at https://github.com/AIoT-MLSys-Lab/Efficient-LLMs-Survey. We will actively maintain the repository and incorporate new research as it emerges. We hope our survey can serve as a valuable resource to help researchers and practitioners gain a systematic understanding of efficient LLMs research and inspire them to contribute to this important and exciting field.

Jing Xiong, Zhongwei Wan, Xiping Hu et al.

Math word problems (MWPs) is a task that automatically derives solution expression from a giving math problems in text. The previous studies suffer from spurious correlations between input text and output expression. To mitigate this issue, we propose a self-consistent reasoning framework called SCR, which attempts to adopt a pruning strategy to correct the output distribution shift so as to implicitly fix those spurious correlative samples. Specifically, we firstly obtain a sub-network by pruning a roberta2tree model, for the sake to use the gap on output distribution between the original roberta2tree model and the pruned sub-network to expose spurious correlative samples. Then, we calibrate the output distribution shift by applying symmetric Kullback-Leibler divergence to alleviate spurious correlations. In addition, SCR generates equivalent expressions, thereby, capturing the original text's logic rather than relying on hints from original text. Extensive experiments on two large-scale benchmarks demonstrate that our model substantially outperforms the strong baseline methods.

Xin Wang, Yu Zheng, Zhongwei Wan et al.

The advancements in Large Language Models (LLMs) have been hindered by their substantial sizes, which necessitates LLM compression methods for practical deployment. Singular Value Decomposition (SVD) offers a promising solution for LLM compression. However, state-of-the-art SVD-based LLM compression methods have two key limitations: truncating smaller singular values may lead to higher compression loss, and the lack of update on the compressed weights after SVD truncation. In this work, we propose SVD-LLM, a SVD-based post-training LLM compression method that addresses the limitations of existing methods. SVD-LLM incorporates a truncation-aware data whitening technique to ensure a direct mapping between singular values and compression loss. Moreover, SVD-LLM adopts a parameter update with sequential low-rank approximation to compensate for the accuracy degradation after SVD compression. We evaluate SVD-LLM on 10 datasets and seven models from three different LLM families at three different scales. Our results demonstrate the superiority of SVD-LLM over state-of-the-arts, especially at high model compression ratios. Our code is available at https://github.com/AIoT-MLSys-Lab/SVD-LLM

Che Liu, Zhongwei Wan, Cheng Ouyang et al.

Electrocardiograms (ECGs) are non-invasive diagnostic tools crucial for detecting cardiac arrhythmic diseases in clinical practice. While ECG Self-supervised Learning (eSSL) methods show promise in representation learning from unannotated ECG data, they often overlook the clinical knowledge that can be found in reports. This oversight and the requirement for annotated samples for downstream tasks limit eSSL's versatility. In this work, we address these issues with the Multimodal ECG Representation Learning (MERL}) framework. Through multimodal learning on ECG records and associated reports, MERL is capable of performing zero-shot ECG classification with text prompts, eliminating the need for training data in downstream tasks. At test time, we propose the Clinical Knowledge Enhanced Prompt Engineering (CKEPE) approach, which uses Large Language Models (LLMs) to exploit external expert-verified clinical knowledge databases, generating more descriptive prompts and reducing hallucinations in LLM-generated content to boost zero-shot classification. Based on MERL, we perform the first benchmark across six public ECG datasets, showing the superior performance of MERL compared against eSSL methods. Notably, MERL achieves an average AUC score of 75.2% in zero-shot classification (without training data), 3.2% higher than linear probed eSSL methods with 10\% annotated training data, averaged across all six datasets. Code and models are available at https://github.com/cheliu-computation/MERL

Jing Xiong, Gongye Liu, Lun Huang et al.

Autoregressive modeling has been a huge success in the field of natural language processing (NLP). Recently, autoregressive models have emerged as a significant area of focus in computer vision, where they excel in producing high-quality visual content. Autoregressive models in NLP typically operate on subword tokens. However, the representation strategy in computer vision can vary in different levels, i.e., pixel-level, token-level, or scale-level, reflecting the diverse and hierarchical nature of visual data compared to the sequential structure of language. This survey comprehensively examines the literature on autoregressive models applied to vision. To improve readability for researchers from diverse research backgrounds, we start with preliminary sequence representation and modeling in vision. Next, we divide the fundamental frameworks of visual autoregressive models into three general sub-categories, including pixel-based, token-based, and scale-based models based on the representation strategy. We then explore the interconnections between autoregressive models and other generative models. Furthermore, we present a multifaceted categorization of autoregressive models in computer vision, including image generation, video generation, 3D generation, and multimodal generation. We also elaborate on their applications in diverse domains, including emerging domains such as embodied AI and 3D medical AI, with about 250 related references. Finally, we highlight the current challenges to autoregressive models in vision with suggestions about potential research directions. We have also set up a Github repository to organize the papers included in this survey at: https://github.com/ChaofanTao/Autoregressive-Models-in-Vision-Survey.

Zhongwei Wan

In recent years, with the rapid development of information on the Internet, the number of complex texts and documents has increased exponentially, which requires a deeper understanding of deep learning methods in order to accurately classify texts using deep learning techniques, and thus deep learning methods have become increasingly important in text classification. Text classification is a class of tasks that automatically classifies a set of documents into multiple predefined categories based on their content and subject matter. Thus, the main goal of text classification is to enable users to extract information from textual resources and process processes such as retrieval, classification, and machine learning techniques together in order to classify different categories. Many new techniques of deep learning have already achieved excellent results in natural language processing. The success of these learning algorithms relies on their ability to understand complex models and non-linear relationships in data. However, finding the right structure, architecture, and techniques for text classification is a challenge for researchers. This paper introduces deep learning-based text classification algorithms, including important steps required for text classification tasks such as feature extraction, feature reduction, and evaluation strategies and methods. At the end of the article, different deep learning text classification methods are compared and summarized.

Zixuan Gong, Guangyin Bao, Qi Zhang et al.

Reconstruction of static visual stimuli from non-invasion brain activity fMRI achieves great success, owning to advanced deep learning models such as CLIP and Stable Diffusion. However, the research on fMRI-to-video reconstruction remains limited since decoding the spatiotemporal perception of continuous visual experiences is formidably challenging. We contend that the key to addressing these challenges lies in accurately decoding both high-level semantics and low-level perception flows, as perceived by the brain in response to video stimuli. To the end, we propose NeuroClips, an innovative framework to decode high-fidelity and smooth video from fMRI. NeuroClips utilizes a semantics reconstructor to reconstruct video keyframes, guiding semantic accuracy and consistency, and employs a perception reconstructor to capture low-level perceptual details, ensuring video smoothness. During inference, it adopts a pre-trained T2V diffusion model injected with both keyframes and low-level perception flows for video reconstruction. Evaluated on a publicly available fMRI-video dataset, NeuroClips achieves smooth high-fidelity video reconstruction of up to 6s at 8FPS, gaining significant improvements over state-of-the-art models in various metrics, e.g., a 128% improvement in SSIM and an 81% improvement in spatiotemporal metrics. Our project is available at https://github.com/gongzix/NeuroClips.

Hui Shen, Jingxuan Zhang, Boning Xiong et al.

Diffusion models have emerged as powerful generative models capable of producing high-quality contents such as images, videos, and audio, demonstrating their potential to revolutionize digital content creation. However, these capabilities come at the cost of their significant computational resources and lengthy generation time, underscoring the critical need to develop efficient techniques for practical deployment. In this survey, we provide a systematic and comprehensive review of research on efficient diffusion models. We organize the literature in a taxonomy consisting of three main categories, covering distinct yet interconnected efficient diffusion model topics from algorithm-level, system-level, and framework perspective, respectively. We have also created a GitHub repository where we organize the papers featured in this survey at https://github.com/AIoT-MLSys-Lab/Efficient-Diffusion-Model-Survey. We hope our survey can serve as a valuable resource to help researchers and practitioners gain a systematic understanding of efficient diffusion model research and inspire them to contribute to this important and exciting field.

Zhongwei Wan, Che Liu, Xin Wang et al.

Electrocardiogram (ECG) is the primary non-invasive diagnostic tool for monitoring cardiac conditions and is crucial in assisting clinicians. Recent studies have concentrated on classifying cardiac conditions using ECG data but have overlooked ECG report generation, which is time-consuming and requires clinical expertise. To automate ECG report generation and ensure its versatility, we propose the Multimodal ECG Instruction Tuning (MEIT) framework, the first attempt to tackle ECG report generation with LLMs and multimodal instructions. To facilitate future research, we establish a benchmark to evaluate MEIT with various LLMs backbones across two large-scale ECG datasets. Our approach uniquely aligns the representations of the ECG signal and the report, and we conduct extensive experiments to benchmark MEIT with nine open-source LLMs using more than 800,000 ECG reports. MEIT's results underscore the superior performance of instruction-tuned LLMs, showcasing their proficiency in quality report generation, zero-shot capabilities, resilience to signal perturbation, and alignment with human expert evaluation. These findings emphasize the efficacy of MEIT and its potential for real-world clinical application.

Zhongwei Wan, Hui Shen, Xin Wang et al.

Long-context Multimodal Large Language Models (MLLMs) that incorporate long text-image and text-video modalities, demand substantial resources as their multimodal Key-Value (KV) caches grow with increasing input lengths, challenging inference efficiency. Existing methods for KV cache compression, in both text-only and multimodal LLMs, have neglected attention density variations across layers, thus often adopting uniform or progressive reduction strategies for layer-wise cache allocation. In this work, we propose MEDA, a dynamic layer-wise KV cache allocation method for efficient multimodal long-context inference. As its core, MEDA utilizes cross-modal attention entropy to determine the KV cache size at each MLLMs layer. Given the dynamically allocated KV cache size at each layer, MEDA also employs a KV pair selection scheme to identify which KV pairs to select and a KV pair merging strategy that merges the selected and non-selected ones to preserve information from the entire context. MEDA achieves up to 72% KV cache memory reduction and 2.82 times faster decoding speed, while maintaining or enhancing performance on various multimodal tasks in long-context settings, including multi-images and long-video scenarios. Our code is released at https://github.com/AIoT-MLSys-Lab/MEDA.

Jing Xiong, Jianghan Shen, Chuanyang Zheng et al.

Extrapolating ultra-long contexts (text length >128K) remains a major challenge for large language models (LLMs), as most training-free extrapolation methods are not only severely limited by memory bottlenecks, but also suffer from the attention sink, which restricts their scalability and effectiveness in practice. In this work, we propose ParallelComp, a parallel long-context compression method that effectively overcomes the memory bottleneck, enabling 8B-parameter LLMs to extrapolate from 8K to 128K tokens on a single A100 80GB GPU in a training-free setting. ParallelComp splits the input into chunks, dynamically evicting redundant chunks and irrelevant tokens, supported by a parallel KV cache eviction mechanism. Importantly, we present a systematic theoretical and empirical analysis of attention biases in parallel attention-including the attention sink, recency bias, and middle bias-and reveal that these biases exhibit distinctive patterns under ultra-long context settings. We further design a KV cache eviction technique to mitigate this phenomenon. Experimental results show that ParallelComp enables an 8B model (trained on 8K context) to achieve 91.17% of GPT-4's performance under ultra-long contexts, outperforming closed-source models such as Claude-2 and Kimi-Chat. We achieve a 1.76x improvement in chunk throughput, thereby achieving a 23.50x acceleration in the prefill stage with negligible performance loss and pave the way for scalable and robust ultra-long contexts extrapolation in LLMs. We release the code at https://github.com/menik1126/ParallelComp.

Jing Xiong, Qiujiang Chen, Fanghua Ye et al.

Large language models (LLMs) benefit from test-time scaling but are often hampered by high inference latency. Speculative decoding is a natural way to accelerate the scaling process; however, scaling along both the parallel and sequential dimensions poses significant challenges, including substantial memory-bound execution and synchronization overhead. We introduce ATTS (Asynchronous Test-Time Scaling), a statistically guaranteed adaptive scaling framework that follows the hypothesis testing process to address these challenges. By revisiting arithmetic intensity, ATTS identifies synchronization as the primary bottleneck. It enables asynchronous inference through online calibration and proposes an ordinal classification algorithm that supports a three-stage rejection sampling pipeline, scaling along both the sequential and parallel axes. Across experiments on the MATH, AMC23, AIME24, and AIME25 datasets and across multiple draft-target model families, we show that ATTS delivers up to 56.7x speedup in test-time scaling and a 4.14x throughput improvement, while maintaining accurate control of the rejection rate, reducing latency and memory overhead, and incurring no accuracy loss. By scaling both in parallel and sequential dimensions, we enable the 1.5B/70B draft/target model combination to achieve the performance of the state-of-the-art reasoning model o3-mini (high) on the AIME dataset. We have released the code at https://github.com/menik1126/asynchronous-test-time-scaling.

Shujun Xia, Haokun Lin, Yichen Wu et al.

LLMs hold great promise for healthcare applications, but the rapid evolution of medical knowledge and errors in training data often cause them to generate outdated or inaccurate information, limiting their applicability in high-stakes clinical practice. Model editing has emerged as a potential remedy without full retraining. While parameter-based editing often compromises locality and is thus ill-suited for the medical domain, retrieval-based editing offers a more viable alternative. However, it still faces two critical challenges: (1) representation overlap within the medical knowledge space often causes inaccurate retrieval and reduces editing accuracy; (2) existing methods are restricted to single-sample edits, while batch-editing remains largely unexplored despite its importance for real-world medical applications. To address these challenges, we first construct MedVersa, an enhanced benchmark with broader coverage of medical subjects, designed to evaluate both single and batch edits under strict locality constraints. We then propose MedREK, a retrieval-based editing framework that integrates a shared query-key module for precise matching with an attention-based prompt encoder for informative guidance. Experimental results on various medical benchmarks demonstrate that our MedREK achieves superior performance across different core metrics and provides the first validated solution for batch-editing in medical LLMs. Our code and dataset are available at https://github.com/mylittleriver/MedREK.

Kangyu Zheng, Yingzhou Lu, Zaixi Zhang et al.

Currently, the field of structure-based drug design is dominated by three main types of algorithms: search-based algorithms, deep generative models, and reinforcement learning. While existing works have typically focused on comparing models within a single algorithmic category, cross-algorithm comparisons remain scarce. In this paper, to fill the gap, we establish a benchmark to evaluate the performance of sixteen models across these different algorithmic foundations by assessing the pharmaceutical properties of the generated molecules and their docking affinities with specified target proteins. We highlight the unique advantages of each algorithmic approach and offer recommendations for the design of future SBDD models. We emphasize that 1D/2D ligand-centric drug design methods can be used in SBDD by treating the docking function as a black-box oracle, which is typically neglected. The empirical results show that 1D/2D methods achieve competitive performance compared with 3D-based methods that use the 3D structure of the target protein explicitly. Also, AutoGrow4, a 2D molecular graph-based genetic algorithm, dominates SBDD in terms of optimization ability. The relevant code is available in https://github.com/zkysfls/2024-sbdd-benchmark.

Canyu Chen, Jian Yu, Shan Chen et al. · harvard

Large Language Models (LLMs) hold great promise to revolutionize current clinical systems for their superior capacities on medical text processing tasks and medical licensing exams. Meanwhile, traditional ML models such as SVM and XGBoost have still been mainly adopted in clinical prediction tasks. An emerging question is Can LLMs beat traditional ML models in clinical prediction? Thus, we build a new benchmark ClinicalBench to comprehensively study the clinical predictive modeling capacities of both general-purpose and medical LLMs, and compare them with traditional ML models. ClinicalBench embraces three common clinical prediction tasks, two databases, 14 general-purpose LLMs, 8 medical LLMs, and 11 traditional ML models. Through extensive empirical investigation, we discover that both general-purpose and medical LLMs, even with different model scales, diverse prompting or fine-tuning strategies, still cannot beat traditional ML models in clinical prediction yet, shedding light on their potential deficiency in clinical reasoning and decision-making. We call for caution when practitioners adopt LLMs in clinical applications. ClinicalBench can be utilized to bridge the gap between LLMs' development for healthcare and real-world clinical practice.

Xin Wang, Zhongwei Wan, Arvin Hekmati et al.

Advancements in Generative AI hold immense promise to push Internet of Things (IoT) to the next level. In this article, we share our vision on IoT in the era of Generative AI. We discuss some of the most important applications of Generative AI in IoT-related domains. We also identify some of the most critical challenges and discuss current gaps as well as promising opportunities on enabling Generative AI for IoT. We hope this article can inspire new research on IoT in the era of Generative AI.

Hui Shen, Taiqiang Wu, Qi Han et al.

Existing benchmarks fail to capture a crucial aspect of intelligence: physical reasoning, the integrated ability to combine domain knowledge, symbolic reasoning, and understanding of real-world constraints. To address this gap, we introduce PhyX: the first large-scale benchmark designed to assess models capacity for physics-grounded reasoning in visual scenarios. PhyX includes 3K meticulously curated multimodal questions spanning 6 reasoning types across 25 sub-domains and 6 core physics domains: thermodynamics, electromagnetism, mechanics, modern physics, optics, and wave\&acoustics. In our comprehensive evaluation, even state-of-the-art models struggle significantly with physical reasoning. GPT-4o, Claude3.7-Sonnet, and GPT-o4-mini achieve only 32.5%, 42.2%, and 45.8% accuracy respectively-performance gaps exceeding 29% compared to human experts. Our analysis exposes critical limitations in current models: over-reliance on memorized disciplinary knowledge, excessive dependence on mathematical formulations, and surface-level visual pattern matching rather than genuine physical understanding. We provide in-depth analysis through fine-grained statistics, detailed case studies, and multiple evaluation paradigms to thoroughly examine physical reasoning capabilities. To ensure reproducibility, we implement a compatible evaluation protocol based on widely-used toolkits such as VLMEvalKit, enabling one-click evaluation. More details are available on our project page: https://phyx-bench.github.io/.

Che Liu, Zhongwei Wan, Haozhe Wang et al.

Medical Vision-Language Pre-training (MedVLP) has made significant progress in enabling zero-shot tasks for medical image understanding. However, training MedVLP models typically requires large-scale datasets with paired, high-quality image-text data, which are scarce in the medical domain. Recent advancements in Large Language Models (LLMs) and diffusion models have made it possible to generate large-scale synthetic image-text pairs. This raises the question: "Can MedVLP succeed using purely synthetic data?" To address this, we use off-the-shelf generative models to create synthetic radiology reports and paired Chest X-ray (CXR) images, and propose an automated pipeline to build a diverse, high-quality synthetic dataset, enabling a rigorous study that isolates model and training settings, focusing entirely from the data perspective. Our results show that MedVLP models trained exclusively on synthetic data outperform those trained on real data by 3.8% in averaged AUC on zero-shot classification. Moreover, using a combination of synthetic and real data leads to a further improvement of 9.07%. Additionally, MedVLP models trained on synthetic or mixed data consistently outperform those trained on real data in zero-shot grounding, as well as in fine-tuned classification and segmentation tasks. Our analysis suggests MedVLP trained on well-designed synthetic data can outperform models trained on real datasets, which may be limited by low-quality samples and long-tailed distributions.

Yu Zhang, Jialei Zhou, Xinchen Li et al.

Current text-to-image diffusion generation typically employs complete-text conditioning. Due to the intricate syntax, diffusion transformers (DiTs) inherently suffer from a comprehension defect of complete-text captions. One-fly complete-text input either overlooks critical semantic details or causes semantic confusion by simultaneously modeling diverse semantic primitive types. To mitigate this defect of DiTs, we propose a novel split-text conditioning framework named DiT-ST. This framework converts a complete-text caption into a split-text caption, a collection of simplified sentences, to explicitly express various semantic primitives and their interconnections. The split-text caption is then injected into different denoising stages of DiT-ST in a hierarchical and incremental manner. Specifically, DiT-ST leverages Large Language Models to parse captions, extracting diverse primitives and hierarchically sorting out and constructing these primitives into a split-text input. Moreover, we partition the diffusion denoising process according to its differential sensitivities to diverse semantic primitive types and determine the appropriate timesteps to incrementally inject tokens of diverse semantic primitive types into input tokens via cross-attention. In this way, DiT-ST enhances the representation learning of specific semantic primitive types across different stages. Extensive experiments validate the effectiveness of our proposed DiT-ST in mitigating the complete-text comprehension defect.

Che Liu, Cheng Ouyang, Zhongwei Wan et al.

Recent advances in multimodal ECG representation learning center on aligning ECG signals with paired free-text reports. However, suboptimal alignment persists due to the complexity of medical language and the reliance on a full 12-lead setup, which is often unavailable in under-resourced settings. To tackle these issues, we propose **K-MERL**, a knowledge-enhanced multimodal ECG representation learning framework. **K-MERL** leverages large language models to extract structured knowledge from free-text reports and employs a lead-aware ECG encoder with dynamic lead masking to accommodate arbitrary lead inputs. Evaluations on six external ECG datasets show that **K-MERL** achieves state-of-the-art performance in zero-shot classification and linear probing tasks, while delivering an average **16%** AUC improvement over existing methods in partial-lead zero-shot classification.

Zhihao Dou, Qinjian Zhao, Zhongwei Wan et al.

Large language models (LLMs) have demonstrated remarkable reasoning abilities in complex tasks, often relying on Chain-of-Thought (CoT) reasoning. However, due to their autoregressive token-level generation, the reasoning process is largely constrained to local decision-making and lacks global planning. This limitation frequently results in redundant, incoherent, or inaccurate reasoning, which significantly degrades overall performance. Existing approaches, such as tree-based algorithms and reinforcement learning (RL), attempt to address this issue but suffer from high computational costs and often fail to produce optimal reasoning trajectories. To tackle this challenge, we propose Plan-Then-Action Enhanced Reasoning with Group Relative Policy Optimization PTA-GRPO, a two-stage framework designed to improve both high-level planning and fine-grained CoT reasoning. In the first stage, we leverage advanced LLMs to distill CoT into compact high-level guidance, which is then used for supervised fine-tuning (SFT). In the second stage, we introduce a guidance-aware RL method that jointly optimizes the final output and the quality of high-level guidance, thereby enhancing reasoning effectiveness. We conduct extensive experiments on multiple mathematical reasoning benchmarks, including MATH, AIME2024, AIME2025, and AMC, across diverse base models such as Qwen2.5-7B-Instruct, Qwen3-8B, Qwen3-14B, and LLaMA3.2-3B. Experimental results demonstrate that PTA-GRPO consistently achieves stable and significant improvements across different models and tasks, validating its effectiveness and generalization.

Wendong Xu, Jing Xiong, Chenyang Zhao et al.

We present SwingArena, a competitive evaluation framework for Large Language Models (LLMs) that closely mirrors real-world software development workflows. Unlike traditional static benchmarks, SwingArena models the collaborative process of software iteration by pairing LLMs as submitters, who generate patches, and reviewers, who create test cases and verify the patches through continuous integration (CI) pipelines. To support these interactive evaluations, we introduce a retrieval-augmented code generation (RACG) module that efficiently handles long-context challenges by providing syntactically and semantically relevant code snippets from large codebases, supporting multiple programming languages (C++, Python, Rust, and Go). This enables the framework to scale across diverse tasks and contexts while respecting token limitations. Our experiments, using over 400 high-quality real-world GitHub issues selected from a pool of 2,300 issues, show that models like GPT-4o excel at aggressive patch generation, whereas DeepSeek and Gemini prioritize correctness in CI validation. SwingArena presents a scalable and extensible methodology for evaluating LLMs in realistic, CI-driven software development settings. More details are available on our project page: swing-bench.github.io

Alex ZH Dou, Zhongwei Wan, Dongfei Cui et al.

Test-time scaling has emerged as a promising paradigm in language modeling, leveraging additional computational resources at inference time to enhance model performance. In this work, we introduce R2-LLMs, a novel and versatile hierarchical retrieval-augmented reasoning framework designed to improve test-time scaling in large language models (LLMs) without requiring distillation from more advanced models to obtain chain-of-thought (CoT) training data. R2-LLMs enhances inference-time generalization by integrating dual-level retrieval-based in-context learning: (1) At the coarse level, our approach extracts abstract templates from complex reasoning problems and retrieves similar problem-answer pairs to facilitate high-level in-context learning; (2) At the fine level, during Monte Carlo Tree Search (MCTS), R2-LLMs efficiently retrieves analogous intermediate solution steps from reference mathematical problem datasets, refining step-wise reasoning with the aid of a process reward model (PRM) for scoring. R2-LLMs is a robust hierarchical reasoning-augmentation method that enhances in-context-level reasoning while seamlessly integrating with step-level tree search methods. Utilizing PRM, it refines both candidate generation and decision-making for improved reasoning accuracy. Empirical evaluations on the MATH500, GSM8K, and OlympiadBench-TO datasets achieve substantial relative improvement with an increase of up to 16% using LLaMA-3.1-8B compared to the baselines, showcasing the effectiveness of our approach in complex reasoning tasks.

Zhongwei Wan, Ziang Wu, Che Liu et al.

Long-context Multimodal Large Language Models (MLLMs) demand substantial computational resources for inference as the growth of their multimodal Key-Value (KV) cache, in response to increasing input lengths, challenges memory and time efficiency. Unlike single-modality LLMs that manage only textual contexts, the KV cache of long-context MLLMs includes representations from multiple images with temporal and spatial relationships and related textual contexts. The predominance of image tokens means traditional optimizations for LLMs' KV caches are unsuitable for multimodal long-context settings, and no prior works have addressed this challenge. In this work, we introduce LOOK-M, a pioneering, fine-tuning-free approach that efficiently reduces the multimodal KV cache size while maintaining performance comparable to a full cache. We observe that during prompt prefill, the model prioritizes more textual attention over image features, and based on the multimodal interaction observation, a new proposed text-prior method is explored to compress the KV cache. Furthermore, to mitigate the degradation of image contextual information, we propose several compensatory strategies using KV pairs merging. LOOK-M demonstrates that with a significant reduction in KV Cache memory usage, such as reducing it by 80% in some cases, it not only achieves up to 1.5x faster decoding but also maintains or even enhances performance across a variety of long context multimodal tasks.

Zhongwei Wan, Xinjian Wu, Yu Zhang et al.

Generative inference in Large Language Models (LLMs) is impeded by the growing memory demands of Key-Value (KV) cache, especially for longer sequences. Traditional KV cache eviction strategies, which discard less critical KV pairs based on attention scores, often degrade generation quality, leading to issues such as context loss or hallucinations. In this work, we introduce Dynamic Discriminative Operations (D2O), a KV cache compression method that optimizes KV cache size dynamically and discriminatively at two levels without fine-tuning, while preserving essential context. At layer level, D2O leverages the varying densities of attention weights between shallow and deep layers to dynamically determine which layers should avoid excessive eviction via a novel dynamic allocation strategy to minimize information loss. At token level, D2O incorporates a compensation mechanism that maintains a similarity threshold to re-discriminate the importance of currently discarded tokens, determining whether they should be recalled and merged with similar tokens. We conduct experiments on various benchmarks and LLM architectures. Our results show that D2O not only achieves significant memory savings and enhances inference throughput by more than 3$\times$ but also maintains high-quality long-text generation.

Che Liu, Zhongwei Wan, Yuqi Wang et al.

Automatic radiology report generation holds significant potential to streamline the labor-intensive process of report writing by radiologists, particularly for 3D radiographs such as CT scans. While CT scans are critical for clinical diagnostics, they remain less explored compared to 2D radiographs. To date, there has been no comprehensive benchmark for 3D radiograph report generation (3DRRG), nor sufficient investigation into the optimal training strategies for Vision Language Models (VLMs) in this context, particularly with respect to vision encoder choices, visual token compression, and model scaling. In this work, we make three key contributions. We curate **CT-3DRRG**, the largest **publicly** available 3D CT-report dataset, establishing a robust and diverse benchmark for evaluating VLM performance on 3DRRG. Furthermore, we propose a comprehensive training recipe for building high-performing VLMs for 3DRRG, exploring key factors such as vision encoder pretraining strategies, visual token compression, and the impact of data & model scale. Guided by these findings, we introduce **Argus**, a state-of-the-art family of VLMs that achieve superior performance across different model sizes and input 3D medical image resolutions, efficiently processing high-resolution 3D images up to $512 \times 512 \times 256$[^1].

Zhongwei Wan, Che Liu, Mi Zhang et al.

The scarcity of data presents a critical obstacle to the efficacy of medical visionlanguage pre-training (VLP). A potential solution lies in the combination of datasets from various language communities. Nevertheless, the main challenge stems from the complexity of integrating diverse syntax and semantics, language-specific medical terminology, and culture-specific implicit knowledge. Therefore, one crucial aspect to consider is the presence of community bias caused by different languages. This paper presents a novel framework named Unifying Cross-Lingual Medical Vision-Language Pre-Training (Med-UniC), designed to integrate multimodal medical data from the two most prevalent languages, English and Spanish. Specifically, we propose Cross-lingual Text Alignment Regularization (CTR) to explicitly unify cross-lingual semantic representations of medical reports originating from diverse language communities. CTR is optimized through latent language disentanglement, rendering our optimization objective to not depend on negative samples, thereby significantly mitigating the bias from determining positive-negative sample pairs within analogous medical reports. Furthermore, it ensures that the cross-lingual representation is not biased toward any specific language community. Med-UniC reaches superior performance across 5 medical image tasks and 10 datasets encompassing over 30 diseases, offering a versatile framework for unifying multi-modal medical data within diverse linguistic communities. The experimental outcomes highlight the presence of community bias in cross-lingual VLP. Reducing this bias enhances the performance not only in vision-language tasks but also in uni-modal visual tasks.

Zhenyu Liang, Yunfan Li, Zhongwei Wan

Estimation of distribution algorithms (EDA) as one of the EAs is a stochastic optimization problem which establishes a probability model to describe the distribution of solutions and randomly samples the probability model to create offspring and optimize model and population. Reference Vector Guided Evolutionary (RVEA) based on the EDA framework, having a better performance to solve MaOPs. Besides, using the generative adversarial networks to generate offspring solutions is also a state-of-art thought in EAs instead of crossover and mutation. In this paper, we will propose a novel algorithm based on RVEA[1] framework and using Distributional Adversarial Networks (DAN) [2]to generate new offspring. DAN uses a new distributional framework for adversarial training of neural networks and operates on genuine samples rather than a single point because the framework also leads to more stable training and extraordinarily better mode coverage compared to single-point-sample methods. Thereby, DAN can quickly generate offspring with high convergence regarding the same distribution of data. In addition, we also use Large-Scale Multi-Objective Optimization Based on A Competitive Swarm Optimizer (LMOCSO)[3] to adopts a new two-stage strategy to update the position in order to significantly increase the search efficiency to find optimal solutions in huge decision space. The propose new algorithm will be tested on 9 benchmark problems in Large scale multi-objective problems (LSMOP). To measure the performance, we will compare our proposal algorithm with some state-of-art EAs e.g., RM-MEDA[4], MO-CMA[10] and NSGA-II.

Zhenyu Liang, Yunfan Li, Zhongwei Wan

Estimation of distribution algorithms (EDA) are stochastic optimization algorithms. EDA establishes a probability model to describe the distribution of solution from the perspective of population macroscopically by statistical learning method, and then randomly samples the probability model to generate a new population. EDA can better solve multi-objective optimal problems (MOPs). However, the performance of EDA decreases in solving many-objective optimal problems (MaOPs), which contains more than three objectives. Reference Vector Guided Evolutionary Algorithm (RVEA), based on the EDA framework, can better solve MaOPs. In our paper, we use the framework of RVEA. However, we generate the new population by Wasserstein Generative Adversarial Networks-Gradient Penalty (WGAN-GP) instead of using crossover and mutation. WGAN-GP have advantages of fast convergence, good stability and high sample quality. WGAN-GP learn the mapping relationship from standard normal distribution to given data set distribution based on a given data set subject to the same distribution. It can quickly generate populations with high diversity and good convergence. To measure the performance, RM-MEDA, MOPSO and NSGA-II are selected to perform comparison experiments over DTLZ and LSMOP test suites with 3-, 5-, 8-, 10- and 15-objective.