Mihai Udrescu

Chenzhong Yin, Mihai Udrescu, Gaurav Gupta et al.

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide. Current COPD diagnosis (i.e., spirometry) could be unreliable because the test depends on an adequate effort from the tester and testee. Moreover, the early diagnosis of COPD is challenging. We address COPD detection by constructing two novel physiological signals datasets (4432 records from 54 patients in the WestRo COPD dataset and 13824 medical records from 534 patients in the WestRo Porti COPD dataset). The authors demonstrate their complex coupled fractal dynamical characteristics and perform a fractional-order dynamics deep learning analysis to diagnose COPD. The authors found that the fractional-order dynamical modeling can extract distinguishing signatures from the physiological signals across patients with all COPD stages from stage 0 (healthy) to stage 4 (very severe). They use the fractional signatures to develop and train a deep neural network that predicts COPD stages based on the input features (such as thorax breathing effort, respiratory rate, or oxygen saturation). The authors show that the fractional dynamic deep learning model (FDDLM) achieves a COPD prediction accuracy of 98.66% and can serve as a robust alternative to spirometry. The FDDLM also has high accuracy when validated on a dataset with different physiological signals.

Stefan-Alexandru Jura, Mihai Udrescu, Alexandru Topirceanu

Long-range time series forecasting remains challenging, as it requires capturing non-stationary and multi-scale temporal dependencies while maintaining noise robustness, efficiency, and stability. Transformer-based architectures such as Autoformer and Informer improve generalization but suffer from quadratic complexity and degraded performance on very long time horizons. State space models, notably S-Mamba, provide linear-time updates but often face unstable training dynamics, sensitivity to initialization, and limited robustness for multivariate forecasting. To address such challenges, we propose the Quantum-Optimized Selective State Space Model (Q-SSM), a hybrid quantum-optimized approach that integrates state space dynamics with a variational quantum gate. Instead of relying on expensive attention mechanisms, Q-SSM employs a simple parametrized quantum circuit (RY-RX ansatz) whose expectation values regulate memory updates adaptively. This quantum gating mechanism improves convergence stability, enhances the modeling of long-term dependencies, and provides a lightweight alternative to attention. We empirically validate Q-SSM on three widely used benchmarks, i.e., ETT, Traffic, and Exchange Rate. Results show that Q-SSM consistently improves over strong baselines (LSTM, TCN, Reformer), Transformer-based models, and S-Mamba. These findings demonstrate that variational quantum gating can address current limitations in long-range forecasting, leading to accurate and robust multivariate predictions.