Chen Jin

Seunghoi Kim, Henry F. J. Tregidgo, Chen Jin et al.

Generative models are prone to hallucinations: plausible but incorrect structures absent in the ground truth. This issue is problematic in image restoration for safety-critical domains such as medical imaging, industrial inspection, and remote sensing, where such errors undermine reliability and trust. For example, in low-field MRI, widely used in resource-limited settings, restoration models are essential for enhancing low-quality scans, yet hallucinations can lead to serious diagnostic errors. Progress has been hindered by a circular dependency: evaluating hallucinations requires labeled data, yet such labels are costly and subjective. We introduce HalluGen, a diffusion-based framework that synthesizes realistic hallucinations with controllable type, location, and severity, producing perceptually realistic but semantically incorrect outputs (segmentation IoU drops from 0.86 to 0.36). Using HalluGen, we construct the first large-scale hallucination dataset comprising 4,350 annotated images derived from 1,450 brain MR images for low-field enhancement, enabling systematic evaluation of hallucination detection and mitigation. We demonstrate its utility in two applications: (1) benchmarking image quality metrics and developing Semantic Hallucination Assessment via Feature Evaluation (SHAFE), a feature-based metric with soft-attention pooling that improves hallucination sensitivity over traditional metrics; and (2) training reference-free hallucination detectors that generalize to real restoration failures. Together, HalluGen and its open dataset establish the first scalable foundation for evaluating hallucinations in safety-critical image restoration.

Chen Jin, Ryutaro Tanno, Amrutha Saseendran et al.

We introduce Lavender, a simple supervised fine-tuning (SFT) method that boosts the performance of advanced vision-language models (VLMs) by leveraging state-of-the-art image generation models such as Stable Diffusion. Specifically, Lavender aligns the text-vision attention in the VLM transformer with the equivalent used by Stable Diffusion during SFT, instead of adapting separate encoders. This alignment enriches the model's visual understanding and significantly boosts performance across in- and out-of-distribution tasks. Lavender requires just 0.13 million training examples, 2.5% of typical large-scale SFT datasets, and fine-tunes on standard hardware (8 GPUs) in a single day. It consistently improves state-of-the-art open-source multimodal LLMs (e.g., Llama-3.2-11B, MiniCPM-Llama3-v2.5), achieving up to 30% gains and a 68% boost on challenging out-of-distribution medical QA tasks. By efficiently transferring the visual expertise of image generators with minimal supervision, Lavender offers a scalable solution for more accurate vision-language systems. All code, training data, and models will be shared at https://astrazeneca.github.io/vlm/.

Seunghoi Kim, Chen Jin, Tom Diethe et al.

Recent developments in diffusion models have advanced conditioned image generation, yet they struggle with reconstructing out-of-distribution (OOD) images, such as unseen tumors in medical images, causing "image hallucination" and risking misdiagnosis. We hypothesize such hallucinations result from local OOD regions in the conditional images. We verify that partitioning the OOD region and conducting separate image generations alleviates hallucinations in several applications. From this, we propose a training-free diffusion framework that reduces hallucination with multiple Local Diffusion processes. Our approach involves OOD estimation followed by two modules: a "branching" module generates locally both within and outside OOD regions, and a "fusion" module integrates these predictions into one. Our evaluation shows our method mitigates hallucination over baseline models quantitatively and qualitatively, reducing misdiagnosis by 40% and 25% in the real-world medical and natural image datasets, respectively. It also demonstrates compatibility with various pre-trained diffusion models.

Seunghoi Kim, Henry F. J. Tregidgo, Matteo Figini et al.

Hallucinations are spurious structures not present in the ground truth, posing a critical challenge in medical image reconstruction, especially for data-driven conditional models. We hypothesize that combining an unconditional diffusion model with data consistency, trained on a diverse dataset, can reduce these hallucinations. Based on this, we propose DynamicDPS, a diffusion-based framework that integrates conditional and unconditional diffusion models to enhance low-quality medical images while systematically reducing hallucinations. Our approach first generates an initial reconstruction using a conditional model, then refines it with an adaptive diffusion-based inverse problem solver. DynamicDPS skips early stage in the reverse process by selecting an optimal starting time point per sample and applies Wolfe's line search for adaptive step sizes, improving both efficiency and image fidelity. Using diffusion priors and data consistency, our method effectively reduces hallucinations from any conditional model output. We validate its effectiveness in Image Quality Transfer for low-field MRI enhancement. Extensive evaluations on synthetic and real MR scans, including a downstream task for tissue volume estimation, show that DynamicDPS reduces hallucinations, improving relative volume estimation by over 15% for critical tissues while using only 5% of the sampling steps required by baseline diffusion models. As a model-agnostic and fine-tuning-free approach, DynamicDPS offers a robust solution for hallucination reduction in medical imaging. The code will be made publicly available upon publication.

Lei Tong, Zhihua Liu, Chaochao Lu et al.

We present Causal-Adapter, a modular framework that adapts frozen text-to-image diffusion backbones for counterfactual image generation. Our method enables causal interventions on target attributes, consistently propagating their effects to causal dependents without altering the core identity of the image. In contrast to prior approaches that rely on prompt engineering without explicit causal structure, Causal-Adapter leverages structural causal modeling augmented with two attribute regularization strategies: prompt-aligned injection, which aligns causal attributes with textual embeddings for precise semantic control, and a conditioned token contrastive loss to disentangle attribute factors and reduce spurious correlations. Causal-Adapter achieves state-of-the-art performance on both synthetic and real-world datasets, with up to 91% MAE reduction on Pendulum for accurate attribute control and 87% FID reduction on ADNI for high-fidelity MRI image generation. These results show that our approach enables robust, generalizable counterfactual editing with faithful attribute modification and strong identity preservation.