Andrea Hartzler

Feng Chen, Manas Bedmutha, Janice Sabin et al.

Depression is underdiagnosed in primary care, yet timely identification remains critical. Recorded clinical encounters, increasingly common with digital scribing technologies, present an opportunity to detect depression from naturalistic dialogue. We investigated automated depression detection from 1,108 audio-recorded primary care encounters in the Establishing Focus study, with depression defined by PHQ-9 (n=253 depressed, n=855 non-depressed). We compared three supervised approaches, Sentence-BERT + Logistic Regression (LR), LIWC+LR and ModernBERT, against a zero-shot GPT-OSS. GPT-OSS achieved the strongest performance (AUPRC=0.510, AUROC=0.774), with LIWC+LR competitive among supervised models (AUPRC=0.500, AUROC=0.742). Combined dyadic transcripts outperformed single-speaker configurations, with providers linguistically mirroring patients in depression encounters, an additive signal not captured by either speaker alone. Meaningful detection is achievable from the first 128 patient tokens (AUPRC=0.356, AUROC=0.675), supporting in-the-moment clinical decision support. These findings argue for passively collected clinical audio as a low-burden complement to existing screening workflows.

Manas Satish Bedmutha, Feng Chen, Andrea Hartzler et al.

Effective communication between providers and their patients influences health and care outcomes. The effectiveness of such conversations has been linked not only to the exchange of clinical information, but also to a range of interpersonal behaviors; commonly referred to as social signals, which are often conveyed through non-verbal cues and shape the quality of the patient-provider relationship. Recent advances in large language models (LLMs) have demonstrated an increasing ability to infer emotional and social behaviors even when analyzing only textual information. As automation increases also in clinical settings, such as for transcription of patient-provider conversations, there is growing potential for LLMs to automatically analyze and extract social behaviors from these interactions. To explore the foundational capabilities of LLMs in tracking social signals in clinical dialogue, we designed task-specific prompts and evaluated model performance across multiple architectures and prompting styles using a highly imbalanced, annotated dataset spanning 20 distinct social signals such as provider dominance, patient warmth, etc. We present the first system capable of tracking all these 20 coded signals, and uncover patterns in LLM behavior. Further analysis of model configurations and clinical context provides insights for enhancing LLM performance on social signal processing tasks in healthcare settings.

Shiwali Mohan, Anusha Venkatakrishnan, Andrea Hartzler

Our research aims to develop interactive, social agents that can coach people to learn new tasks, skills, and habits. In this paper, we focus on coaching sedentary, overweight individuals (i.e., trainees) to exercise regularly. We employ adaptive goal setting in which the intelligent health coach generates, tracks, and revises personalized exercise goals for a trainee. The goals become incrementally more difficult as the trainee progresses through the training program. Our approach is model-based - the coach maintains a parameterized model of the trainee's aerobic capability that drives its expectation of the trainee's performance. The model is continually revised based on trainee-coach interactions. The coach is embodied in a smartphone application, NutriWalking, which serves as a medium for coach-trainee interaction. We adopt a task-centric evaluation approach for studying the utility of the proposed algorithm in promoting regular aerobic exercise. We show that our approach can adapt the trainee program not only to several trainees with different capabilities, but also to how a trainee's capability improves as they begin to exercise more. Experts rate the goals selected by the coach better than other plausible goals, demonstrating that our approach is consistent with clinical recommendations. Further, in a 6-week observational study with sedentary participants, we show that the proposed approach helps increase exercise volume performed each week.