Maurice van Keulen

Meike Nauta, Johannes H. Hegeman, Jeroen Geerdink et al.

Part-prototype models are explainable-by-design image classifiers, and a promising alternative to black box AI. This paper explores the applicability and potential of interpretable machine learning, in particular PIP-Net, for automated diagnosis support on real-world medical imaging data. PIP-Net learns human-understandable prototypical image parts and we evaluate its accuracy and interpretability for fracture detection and skin cancer diagnosis. We find that PIP-Net's decision making process is in line with medical classification standards, while only provided with image-level class labels. Because of PIP-Net's unsupervised pretraining of prototypes, data quality problems such as undesired text in an X-ray or labelling errors can be easily identified. Additionally, we are the first to show that humans can manually correct the reasoning of PIP-Net by directly disabling undesired prototypes. We conclude that part-prototype models are promising for medical applications due to their interpretability and potential for advanced model debugging.

Shreyasi Pathak, Jörg Schlötterer, Jeroen Geerdink et al.

Breast cancer prediction models for mammography assume that annotations are available for individual images or regions of interest (ROIs), and that there is a fixed number of images per patient. These assumptions do not hold in real hospital settings, where clinicians provide only a final diagnosis for the entire mammography exam (case). Since data in real hospital settings scales with continuous patient intake, while manual annotation efforts do not, we develop a framework for case-level breast cancer prediction that does not require any manual annotation and can be trained with case labels readily available at the hospital. Specifically, we propose a two-level multi-instance learning (MIL) approach at patch and image level for case-level breast cancer prediction and evaluate it on two public and one private dataset. We propose a novel domain-specific MIL pooling observing that breast cancer may or may not occur in both sides, while images of both breasts are taken as a precaution during mammography. We propose a dynamic training procedure for training our MIL framework on a variable number of images per case. We show that our two-level MIL model can be applied in real hospital settings where only case labels, and a variable number of images per case are available, without any loss in performance compared to models trained on image labels. Only trained with weak (case-level) labels, it has the capability to point out in which breast side, mammography view and view region the abnormality lies.

Boqian Wu, Qiao Xiao, Shiwei Liu et al.

Deep neural networks have evolved as the leading approach in 3D medical image segmentation due to their outstanding performance. However, the ever-increasing model size and computation cost of deep neural networks have become the primary barrier to deploying them on real-world resource-limited hardware. In pursuit of improving performance and efficiency, we propose a 3D medical image segmentation model, named Efficient to Efficient Network (E2ENet), incorporating two parametrically and computationally efficient designs. i. Dynamic sparse feature fusion (DSFF) mechanism: it adaptively learns to fuse informative multi-scale features while reducing redundancy. ii. Restricted depth-shift in 3D convolution: it leverages the 3D spatial information while keeping the model and computational complexity as 2D-based methods. We conduct extensive experiments on BTCV, AMOS-CT and Brain Tumor Segmentation Challenge, demonstrating that E2ENet consistently achieves a superior trade-off between accuracy and efficiency than prior arts across various resource constraints. E2ENet achieves comparable accuracy on the large-scale challenge AMOS-CT, while saving over 68\% parameter count and 29\% FLOPs in the inference phase, compared with the previous best-performing method. Our code has been made available at: https://github.com/boqian333/E2ENet-Medical.

Shreyasi Pathak, Jörg Schlötterer, Jeroen Veltman et al.

Deep learning models have achieved high performance in medical applications, however, their adoption in clinical practice is hindered due to their black-box nature. Self-explainable models, like prototype-based models, can be especially beneficial as they are interpretable by design. However, if the learnt prototypes are of low quality then the prototype-based models are as good as black-box. Having high quality prototypes is a pre-requisite for a truly interpretable model. In this work, we propose a prototype evaluation framework for coherence (PEF-C) for quantitatively evaluating the quality of the prototypes based on domain knowledge. We show the use of PEF-C in the context of breast cancer prediction using mammography. Existing works on prototype-based models on breast cancer prediction using mammography have focused on improving the classification performance of prototype-based models compared to black-box models and have evaluated prototype quality through anecdotal evidence. We are the first to go beyond anecdotal evidence and evaluate the quality of the mammography prototypes systematically using our PEF-C. Specifically, we apply three state-of-the-art prototype-based models, ProtoPNet, BRAIxProtoPNet++ and PIP-Net on mammography images for breast cancer prediction and evaluate these models w.r.t. i) classification performance, and ii) quality of the prototypes, on three public datasets. Our results show that prototype-based models are competitive with black-box models in terms of classification performance, and achieve a higher score in detecting ROIs. However, the quality of the prototypes are not yet sufficient and can be improved in aspects of relevance, purity and learning a variety of prototypes. We call the XAI community to systematically evaluate the quality of the prototypes to check their true usability in high stake decisions and improve such models further.

Sylvio Barbon Junior, Paolo Ceravolo, Sven Groppe et al.

A Language Model is a term that encompasses various types of models designed to understand and generate human communication. Large Language Models (LLMs) have gained significant attention due to their ability to process text with human-like fluency and coherence, making them valuable for a wide range of data-related tasks fashioned as pipelines. The capabilities of LLMs in natural language understanding and generation, combined with their scalability, versatility, and state-of-the-art performance, enable innovative applications across various AI-related fields, including eXplainable Artificial Intelligence (XAI), Automated Machine Learning (AutoML), and Knowledge Graphs (KG). Furthermore, we believe these models can extract valuable insights and make data-driven decisions at scale, a practice commonly referred to as Big Data Analytics (BDA). In this position paper, we provide some discussions in the direction of unlocking synergies among these technologies, which can lead to more powerful and intelligent AI solutions, driving improvements in data pipelines across a wide range of applications and domains integrating humans, computers, and knowledge.

Meike Nauta, Jan Trienes, Shreyasi Pathak et al.

The rising popularity of explainable artificial intelligence (XAI) to understand high-performing black boxes raised the question of how to evaluate explanations of machine learning (ML) models. While interpretability and explainability are often presented as a subjectively validated binary property, we consider it a multi-faceted concept. We identify 12 conceptual properties, such as Compactness and Correctness, that should be evaluated for comprehensively assessing the quality of an explanation. Our so-called Co-12 properties serve as categorization scheme for systematically reviewing the evaluation practices of more than 300 papers published in the last 7 years at major AI and ML conferences that introduce an XAI method. We find that 1 in 3 papers evaluate exclusively with anecdotal evidence, and 1 in 5 papers evaluate with users. This survey also contributes to the call for objective, quantifiable evaluation methods by presenting an extensive overview of quantitative XAI evaluation methods. Our systematic collection of evaluation methods provides researchers and practitioners with concrete tools to thoroughly validate, benchmark and compare new and existing XAI methods. The Co-12 categorization scheme and our identified evaluation methods open up opportunities to include quantitative metrics as optimization criteria during model training in order to optimize for accuracy and interpretability simultaneously.

R. R. Mauritz, F. P. J. Nijweide, J. Goseling et al.

Data quality problems are a large threat in data science. In this paper, we propose a data-cleaning autoencoder capable of near-automatic data quality improvement. It learns the structure and dependencies in the data and uses it as evidence to identify and correct doubtful values. We apply a probabilistic database approach to represent weak and strong evidence for attribute value repairs. A theoretical framework is provided, and experiments show that it can remove significant amounts of noise (i.e., data quality problems) from categorical and numeric probabilistic data. Our method does not require clean data. We do, however, show that manually cleaning a small fraction of the data significantly improves performance.

Jesper Provoost, Luc Wismans, Sander Van der Drift et al.

Public road authorities and private mobility service providers need information derived from the current and predicted traffic states to act upon the daily urban system and its spatial and temporal dynamics. In this research, a real-time parking area state (occupancy, in- and outflux) prediction model (up to 60 minutes ahead) has been developed using publicly available historic and real time data sources. Based on a case study in a real-life scenario in the city of Arnhem, a Neural Network-based approach outperforms a Random Forest-based one on all assessed performance measures, although the differences are small. Both are outperforming a naive seasonal random walk model. Although the performance degrades with increasing prediction horizon, the model shows a performance gain of over 150% at a prediction horizon of 60 minutes compared with the naive model. Furthermore, it is shown that predicting the in- and outflux is a far more difficult task (i.e. performance gains of 30%) which needs more training data, not based exclusively on occupancy rate. However, the performance of predicting in- and outflux is less sensitive to the prediction horizon. In addition, it is shown that real-time information of current occupancy rate is the independent variable with the highest contribution to the performance, although time, traffic flow and weather variables also deliver a significant contribution. During real-time deployment, the model performs three times better than the naive model on average. As a result, it can provide valuable information for proactive traffic management as well as mobility service providers.