Yan su

Hongru Han, Tingrui Guo, Liming Zhang et al.

Low-light image enhancement (LLIE) has traditionally been formulated as a deterministic mapping. However, this paradigm often struggles to account for the ill-posed nature of the task, where unknown ambient conditions and sensor parameters create a multimodal solution space. Consequently, state-of-the-art methods frequently encounter luminance discrepancies between predictions and labels, often necessitating "gt-mean" post-processing to align output luminance for evaluation. To address this fundamental limitation, we propose a transition toward Controllable Low-light Enhancement (CLE), explicitly reformulating the task as a well-posed conditional problem. To this end, we introduce CLE-RWKV, a holistic framework supported by Light100, a new benchmark featuring continuous real-world illumination transitions. To resolve the conflict between luminance control and chromatic fidelity, a noise-decoupled supervision strategy in the HVI color space is employed, effectively separating illumination modulation from texture restoration. Architecturally, to adapt efficient State Space Models (SSMs) for dense prediction, we leverage a Space-to-Depth (S2D) strategy. By folding spatial neighborhoods into channel dimensions, this design allows the model to recover local inductive biases and effectively bridge the "scanning gap" inherent in flattened visual sequences without sacrificing linear complexity. Experiments across seven benchmarks demonstrate that our approach achieves competitive performance and robust controllability, providing a real-world multi-illumination alternative that significantly reduces the reliance on gt-mean post-processing.

Iraklis Giannakis, Craig Warren, Antonios Giannopoulos et al.

Ground-penetrating radar (GPR) is a mature geophysical method that has gained increasing popularity in planetary science over the past decade. GPR has been utilised both for Lunar and Martian missions providing pivotal information regarding the near surface geology of Terrestrial planets. Within that context, numerous processing pipelines have been suggested to address the unique challenges present in planetary setups. These processing pipelines often require manual tuning resulting to ambiguous outputs open to non-unique interpretations. These pitfalls combined with the large number of planetary GPR data (kilometers in magnitude), highlight the necessity for automatic, objective and advanced processing and interpretation schemes. The current paper investigates the potential of deep learning for interpreting and processing GPR data. The one-shot multi-offset configuration is investigated via a coherent numerical case study, showcasing the potential of deep learning for A) reconstructing the dielectric distribution of the the near surface of Terrestrial planets, and B) filling missing or bad-quality traces. Special care was taken for the numerical data to be both realistic and challenging. Moreover, the generated synthetic data are properly labelled and made publicly available for training future data-driven pipelines and contributing towards developing pre-trained foundation models for GPR.

Yiran Zhu, Wei Yang, Yan su et al.

We propose a multimodal spatiotemporal graph neural network (STG) framework to predict colorectal cancer liver metastasis (CRLM) progression. Current clinical models do not effectively integrate the tumor's spatial heterogeneity, dynamic evolution, and complex multimodal data relationships, limiting their predictive accuracy. Our STG framework combines preoperative CT imaging and clinical data into a heterogeneous graph structure, enabling joint modeling of tumor distribution and temporal evolution through spatial topology and cross-modal edges. The framework uses GraphSAGE to aggregate spatiotemporal neighborhood information and leverages supervised and contrastive learning strategies to enhance the model's ability to capture temporal features and improve robustness. A lightweight version of the model reduces parameter count by 78.55%, maintaining near-state-of-the-art performance. The model jointly optimizes recurrence risk regression and survival analysis tasks, with contrastive loss improving feature representational discriminability and cross-modal consistency. Experimental results on the MSKCC CRLM dataset show a time-adjacent accuracy of 85% and a mean absolute error of 1.1005, significantly outperforming existing methods. The innovative heterogeneous graph construction and spatiotemporal decoupling mechanism effectively uncover the associations between dynamic tumor microenvironment changes and prognosis, providing reliable quantitative support for personalized treatment decisions.

Jie Qin, Wei Yang, Yan Su et al.

In breast cancer HER2 assessment, clinical evaluation relies on combined H&E and IHC images, yet acquiring both modalities is often hindered by clinical constraints and cost. We propose an adaptive bimodal prediction framework that flexibly supports single- or dual-modality inputs through two core innovations: a dynamic branch selector activating modality completion or joint inference based on input availability, and a cross-modal GAN (CM-GAN) enabling feature-space reconstruction of missing modalities. This design dramatically improves H&E-only accuracy from 71.44% to 94.25%, achieves 95.09% with full dual-modality inputs, and maintains 90.28% reliability under single-modality conditions. The "dual-modality preferred, single-modality compatible" architecture delivers near-dual-modality accuracy without mandatory synchronized acquisition, offering a cost-effective solution for resource-limited regions and significantly improving HER2 assessment accessibility.

Wei Yang, Yiran Zhu, Jiayu Shen et al.

Diabetic Macular Edema (DME), a prevalent complication among diabetic patients, constitutes a major cause of visual impairment and blindness. Although deep learning has achieved remarkable progress in medical image analysis, traditional DME diagnosis still relies on extensive annotated data and subjective ophthalmologist assessments, limiting practical applications. To address this, we present RURANET++, an unsupervised learning-based automated DME diagnostic system. This framework incorporates an optimized U-Net architecture with embedded Spatial and Channel Squeeze & Excitation (SCSE) attention mechanisms to enhance lesion feature extraction. During feature processing, a pre-trained GoogLeNet model extracts deep features from retinal images, followed by PCA-based dimensionality reduction to 50 dimensions for computational efficiency. Notably, we introduce a novel clustering algorithm employing multi-projection heads to explicitly control cluster diversity while dynamically adjusting similarity thresholds, thereby optimizing intra-class consistency and inter-class discrimination. Experimental results demonstrate superior performance across multiple metrics, achieving maximum accuracy (0.8411), precision (0.8593), recall (0.8411), and F1-score (0.8390), with exceptional clustering quality. This work provides an efficient unsupervised solution for DME diagnosis with significant clinical implications.

Yan Su, Qiulin Wu, Weizhen Li et al.

The training of deep learning models relies on a large amount of labeled data. However, the high cost of medical labeling seriously hinders the development of deep learning in the medical field. Our study proposes a general disease diagnosis approach based on Zero-Shot Learning. The Siamese neural network is used to find similar diseases for the target diseases, and the U-Net segmentation model is used to accurately segment the key lesions of the disease. Finally, based on the ResNet-Agglomerative clustering algorithm, a clustering model is trained on a large number of sample data of similar diseases to obtain a approximate diagnosis of the target disease. Zero-Shot Learning of the target disease is then successfully achieved. To evaluate the validity of the model, we validated our method on a dataset of ophthalmic diseases in CFP modality. The external dataset was used to test its performance, and the accuracy=0.8395, precision=0.8094, recall=0.8463, F1 Score=0.8274, AUC=0.9226, which exceeded the indexes of most Few-Shot Learning and One-Shot Learning models. It proves that our method has great potential and reference value in the medical field, where annotation data is usually scarce and expensive to obtain.

Zesheng Li, Minwen Liao, Haoran Chen et al.

The hemorrhagic lesion segmentation plays a critical role in ophthalmic diagnosis, directly influencing early disease detection, treatment planning, and therapeutic efficacy evaluation. However, the task faces significant challenges due to lesion morphological variability, indistinct boundaries, and low contrast with background tissues. To improve diagnostic accuracy and treatment outcomes, developing advanced segmentation techniques remains imperative. This paper proposes an adversarial learning-based dynamic architecture adjustment approach that integrates hierarchical U-shaped encoder-decoder, residual blocks, attention mechanisms, and ASPP modules. By dynamically optimizing feature fusion, our method enhances segmentation performance. Experimental results demonstrate a Dice coefficient of 0.6802, IoU of 0.5602, Recall of 0.766, Precision of 0.6525, and Accuracy of 0.9955, effectively addressing the challenges in fundus image hemorrhage segmentation.[* Corresponding author.]

Yilong Yang, Zhuyifan Ye, Yan Su et al.

Current pharmaceutical formulation development still strongly relies on the traditional trial-and-error approach by individual experiences of pharmaceutical scientists, which is laborious, time-consuming and costly. Recently, deep learning has been widely applied in many challenging domains because of its important capability of automatic feature extraction. The aim of this research is to use deep learning to predict pharmaceutical formulations. In this paper, two different types of dosage forms were chosen as model systems. Evaluation criteria suitable for pharmaceutics were applied to assessing the performance of the models. Moreover, an automatic dataset selection algorithm was developed for selecting the representative data as validation and test datasets. Six machine learning methods were compared with deep learning. The result shows the accuracies of both two deep neural networks were above 80% and higher than other machine learning models, which showed good prediction in pharmaceutical formulations. In summary, deep learning with the automatic data splitting algorithm and the evaluation criteria suitable for pharmaceutical formulation data was firstly developed for the prediction of pharmaceutical formulations. The cross-disciplinary integration of pharmaceutics and artificial intelligence may shift the paradigm of pharmaceutical researches from experience-dependent studies to data-driven methodologies.