Samira Nedungadi

Boyi Wei, Zora Che, Nathaniel Li et al.

Open-weight bio-foundation models present a dual-use dilemma. While holding great promise for accelerating scientific research and drug development, they could also enable bad actors to develop more deadly bioweapons. To mitigate the risk posed by these models, current approaches focus on filtering biohazardous data during pre-training. However, the effectiveness of such an approach remains unclear, particularly against determined actors who might fine-tune these models for malicious use. To address this gap, we propose BioRiskEval, a framework to evaluate the robustness of procedures that are intended to reduce the dual-use capabilities of bio-foundation models. BioRiskEval assesses models' virus understanding through three lenses, including sequence modeling, mutational effects prediction, and virulence prediction. Our results show that current filtering practices may not be particularly effective: Excluded knowledge can be rapidly recovered in some cases via fine-tuning, and exhibits broader generalizability in sequence modeling. Furthermore, dual-use signals may already reside in the pretrained representations, and can be elicited via simple linear probing. These findings highlight the challenges of data filtering as a standalone procedure, underscoring the need for further research into robust safety and security strategies for open-weight bio-foundation models.

Chen Bo Calvin Zhang, Christina Q. Knight, Nicholas Kruus et al.

Large language models (LLMs) perform increasingly well on biology benchmarks, but it remains unclear whether they uplift novice users -- i.e., enable humans to perform better than with internet-only resources. This uncertainty is central to understanding both scientific acceleration and dual-use risk. We conducted a multi-model, multi-benchmark human uplift study comparing novices with LLM access versus internet-only access across eight biosecurity-relevant task sets. Participants worked on complex problems with ample time (up to 13 hours for the most involved tasks). We found that LLM access provided substantial uplift: novices with LLMs were 4.16 times more accurate than controls (95% CI [2.63, 6.87]). On four benchmarks with available expert baselines (internet-only), novices with LLMs outperformed experts on three of them. Perhaps surprisingly, standalone LLMs often exceeded LLM-assisted novices, indicating that users were not eliciting the strongest available contributions from the LLMs. Most participants (89.6%) reported little difficulty obtaining dual-use-relevant information despite safeguards. Overall, LLMs substantially uplift novices on biological tasks previously reserved for trained practitioners, underscoring the need for sustained, interactive uplift evaluations alongside traditional benchmarks.

Tegan McCaslin, Jide Alaga, Samira Nedungadi et al.

Evaluations of dangerous AI capabilities are important for managing catastrophic risks. Public transparency into these evaluations - including what they test, how they are conducted, and how their results inform decisions - is crucial for building trust in AI development. We propose STREAM (A Standard for Transparently Reporting Evaluations in AI Model Reports), a standard to improve how model reports disclose evaluation results, initially focusing on chemical and biological (ChemBio) benchmarks. Developed in consultation with 23 experts across government, civil society, academia, and frontier AI companies, this standard is designed to (1) be a practical resource to help AI developers present evaluation results more clearly, and (2) help third parties identify whether model reports provide sufficient detail to assess the rigor of the ChemBio evaluations. We concretely demonstrate our proposed best practices with "gold standard" examples, and also provide a three-page reporting template to enable AI developers to implement our recommendations more easily.