Ziqian Guan

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2papers

2 Papers

CVOct 31, 2025Code
Gaussian Combined Distance: A Generic Metric for Object Detection

Ziqian Guan, Xieyi Fu, Pengjun Huang et al.

In object detection, a well-defined similarity metric can significantly enhance model performance. Currently, the IoU-based similarity metric is the most commonly preferred choice for detectors. However, detectors using IoU as a similarity metric often perform poorly when detecting small objects because of their sensitivity to minor positional deviations. To address this issue, recent studies have proposed the Wasserstein Distance as an alternative to IoU for measuring the similarity of Gaussian-distributed bounding boxes. However, we have observed that the Wasserstein Distance lacks scale invariance, which negatively impacts the model's generalization capability. Additionally, when used as a loss function, its independent optimization of the center attributes leads to slow model convergence and unsatisfactory detection precision. To address these challenges, we introduce the Gaussian Combined Distance (GCD). Through analytical examination of GCD and its gradient, we demonstrate that GCD not only possesses scale invariance but also facilitates joint optimization, which enhances model localization performance. Extensive experiments on the AI-TOD-v2 dataset for tiny object detection show that GCD, as a bounding box regression loss function and label assignment metric, achieves state-of-the-art performance across various detectors. We further validated the generalizability of GCD on the MS-COCO-2017 and Visdrone-2019 datasets, where it outperforms the Wasserstein Distance across diverse scales of datasets. Code is available at https://github.com/MArKkwanGuan/mmdet-GCD.

BMJan 16
AutoBinder Agent: An MCP-Based Agent for End-to-End Protein Binder Design

Fukang Ge, Jiarui Zhu, Linjie Zhang et al.

Modern AI technologies for drug discovery are distributed across heterogeneous platforms-including web applications, desktop environments, and code libraries-leading to fragmented workflows, inconsistent interfaces, and high integration overhead. We present an agentic end-to-end drug design framework that leverages a Large Language Model (LLM) in conjunction with the Model Context Protocol (MCP) to dynamically coordinate access to biochemical databases, modular toolchains, and task-specific AI models. The system integrates four state-of-the-art components: MaSIF (MaSIF-site and MaSIF-seed-search) for geometric deep learning-based identification of protein-protein interaction (PPI) sites, Rosetta for grafting protein fragments onto protein backbones to form mini proteins, ProteinMPNN for amino acid sequences redesign, and AlphaFold3 for near-experimental accuracy in complex structure prediction. Starting from a target structure, the framework supports de novo binder generation via surface analysis, scaffold grafting and pose construction, sequence optimization, and structure prediction. Additionally, by replacing rigid, script-based workflows with a protocol-driven, LLM-coordinated architecture, the framework improves reproducibility, reduces manual overhead, and ensures extensibility, portability, and auditability across the entire drug design process.