Song‐Tao Liu

Weijie Kong, Qi Tian, Zijian Zhang et al. · tencent-ai, tsinghua

Recent advancements in video generation have significantly impacted daily life for both individuals and industries. However, the leading video generation models remain closed-source, resulting in a notable performance gap between industry capabilities and those available to the public. In this report, we introduce HunyuanVideo, an innovative open-source video foundation model that demonstrates performance in video generation comparable to, or even surpassing, that of leading closed-source models. HunyuanVideo encompasses a comprehensive framework that integrates several key elements, including data curation, advanced architectural design, progressive model scaling and training, and an efficient infrastructure tailored for large-scale model training and inference. As a result, we successfully trained a video generative model with over 13 billion parameters, making it the largest among all open-source models. We conducted extensive experiments and implemented a series of targeted designs to ensure high visual quality, motion dynamics, text-video alignment, and advanced filming techniques. According to evaluations by professionals, HunyuanVideo outperforms previous state-of-the-art models, including Runway Gen-3, Luma 1.6, and three top-performing Chinese video generative models. By releasing the code for the foundation model and its applications, we aim to bridge the gap between closed-source and open-source communities. This initiative will empower individuals within the community to experiment with their ideas, fostering a more dynamic and vibrant video generation ecosystem. The code is publicly available at https://github.com/Tencent/HunyuanVideo.

Songtao Liu, Dandan Zhang, Zhengkai Tu et al.

A significant challenge in wet lab experiments with current drug design generative models is the trade-off between pharmacological properties and synthesizability. Molecules predicted to have highly desirable properties are often difficult to synthesize, while those that are easily synthesizable tend to exhibit less favorable properties. As a result, evaluating the synthesizability of molecules in general drug design scenarios remains a significant challenge in the field of drug discovery. The commonly used synthetic accessibility (SA) score aims to evaluate the ease of synthesizing generated molecules, but it falls short of guaranteeing that synthetic routes can actually be found. Inspired by recent advances in top-down synthetic route generation and forward reaction prediction, we propose a new, data-driven metric to evaluate molecule synthesizability. This novel metric leverages the synergistic duality between retrosynthetic planners and reaction predictors, both of which are trained on extensive reaction datasets. To demonstrate the efficacy of our metric, we conduct a comprehensive evaluation of round-trip scores across a range of representative molecule generative models.