Lin Zhao

Cheng Wang, Yu Jiang, Zhihao Peng et al.

Functional Magnetic Resonance Imaging (fMRI) is essential for studying brain function and diagnosing neurological disorders, but current analysis methods face reproducibility and transferability issues due to complex pre-processing and task-specific models. We introduce NeuroSTORM (Neuroimaging Foundation Model with Spatial-Temporal Optimized Representation Modeling), a generalizable framework that directly learns from 4D fMRI volumes and enables efficient knowledge transfer across diverse applications. NeuroSTORM is pre-trained on 28.65 million fMRI frames (>9,000 hours) from over 50,000 subjects across multiple centers and ages 5 to 100. Using a Mamba backbone and a shifted scanning strategy, it efficiently processes full 4D volumes. We also propose a spatial-temporal optimized pre-training approach and task-specific prompt tuning to improve transferability. NeuroSTORM outperforms existing methods across five tasks: age/gender prediction, phenotype prediction, disease diagnosis, fMRI-to-image retrieval, and task-based fMRI classification. It demonstrates strong clinical utility on datasets from hospitals in the U.S., South Korea, and Australia, achieving top performance in disease diagnosis and cognitive phenotype prediction. NeuroSTORM provides a standardized, open-source foundation model to improve reproducibility and transferability in fMRI-based clinical research.

Tianyu Xu, Yaoyu Cheng, Pinxi Shen et al.

Quadrupedal robots can learn versatile locomotion skills but remain vulnerable when one or more joints lose power. In contrast, dogs and cats can adopt limping gaits when injured, demonstrating their remarkable ability to adapt to physical conditions. Inspired by such adaptability, this paper presents Action Learner (AcL), a novel teacher-student reinforcement learning framework that enables quadrupeds to autonomously adapt their gait for stable walking under multiple joint faults. Unlike conventional teacher-student approaches that enforce strict imitation, AcL leverages teacher policies to generate style rewards, guiding the student policy without requiring precise replication. We train multiple teacher policies, each corresponding to a different fault condition, and subsequently distill them into a single student policy with an encoder-decoder architecture. While prior works primarily address single-joint faults, AcL enables quadrupeds to walk with up to four faulty joints across one or two legs, autonomously switching between different limping gaits when faults occur. We validate AcL on a real Go2 quadruped robot under single- and double-joint faults, demonstrating fault-tolerant, stable walking, smooth gait transitions between normal and lamb gaits, and robustness against external disturbances.

X. Jiang, J. Qiu, K. Gustavsson et al.

Artificial gliders are designed to disperse as they settle through a fluid, requiring precise navigation to reach target locations. We show that a compact glider settling in a viscous fluid can navigate by dynamically adjusting its centre-of-mass. Using fully resolved direct numerical simulations (DNS) and reinforcement learning, we find two optimal navigation strategies that allow the glider to reach its target location accurately. These strategies depend sensitively on how the glider interacts with the surrounding fluid. The nature of this interaction changes as the particle Reynolds number Re$_p$ changes. Our results explain how the optimal strategy depends on Re$_p$. At large Re$_p$, the glider learns to tumble rapidly by moving its centre-of-mass as its orientation changes. This generates a large horizontal inertial lift force, which allows the glider to travel far. At small Re$_p$, by contrast, high viscosity hinders tumbling. In this case, the glider learns to adjust its centre-of-mass so that it settles with a steady, inclined orientation that results in a horizontal viscous force. The horizontal range is much smaller than for large Re$_p$, because this viscous force is much smaller than the inertial lift force at large Re$_p$. *These authors contributed equally.