Marco Crepaldi

Maryam Sadeghi, Darío Fernández Khatiboun, Yasser Rezaeiyan et al.

Closed-loop brain stimulation holds potential as personalized treatment for drug-resistant epilepsy (DRE) but still suffers from limitations that result in highly variable efficacy. First, stimulation is typically delivered upon detection of the seizure to abort rather than prevent it; second, the stimulation parameters are established by trial and error, requiring lengthy rounds of fine-tuning, which delay steady-state therapeutic efficacy. Here, we address these limitations by leveraging the potential of neuromorphic computing. We present a neuromorphic reservoir computing hardware system capable of driving real-time personalized free-run stimulations based on seizure forecasting, wherein each forecast triggers an electrical pulse rather than an arbitrarily predefined fixed-frequency stimulus train. The system achieves 83.33% accuracy in forecasting seizure occurrences during the training phase. We validate the system using hippocampal spheroids coupled to 3D microelectrode array as a simplified testbed, achieving seizure reduction >97% during the real-time processing while primarily using instantaneous stimulation frequencies within 20 Hz, well below what typically used in clinical practice. Our work demonstrates the potential of neuromorphic systems as a next-generation neuromodulation strategy for personalized DRE treatment, leveraging their sparse and event-driven processing for real-time applications.

Younggeol Cho, Elisa Motta, Olivia Nocentini et al.

Human pose estimation and action recognition have received attention due to their critical roles in healthcare monitoring, rehabilitation, and assistive technologies. In this study, we proposed a novel architecture named Transformer based Encoder Decoder Network (TED Net) designed for estimating human skeleton poses from WiFi Channel State Information (CSI). TED Net integrates convolutional encoders with transformer based attention mechanisms to capture spatiotemporal features from CSI signals. The estimated skeleton poses were used as input to a customized Directed Graph Neural Network (DGNN) for action recognition. We validated our model on two datasets: a publicly available multi modal dataset for assessing general pose estimation, and a newly collected dataset focused on fall related scenarios involving 20 participants. Experimental results demonstrated that TED Net outperformed existing approaches in pose estimation, and that the DGNN achieves reliable action classification using CSI based skeletons, with performance comparable to RGB based systems. Notably, TED Net maintains robust performance across both fall and non fall cases. These findings highlight the potential of CSI driven human skeleton estimation for effective action recognition, particularly in home environments such as elderly fall detection. In such settings, WiFi signals are often readily available, offering a privacy preserving alternative to vision based methods, which may raise concerns about continuous camera monitoring.