Mengyang Wang

Yize Jiang, Xinze Li, Yuanyuan Zhang et al.

Existing protein-ligand docking studies typically focus on the self-docking scenario, which is less practical in real applications. Moreover, some studies involve heavy frameworks requiring extensive training, posing challenges for convenient and efficient assessment of docking methods. To fill these gaps, we design PoseX, an open-source benchmark to evaluate both self-docking and cross-docking, enabling a practical and comprehensive assessment of algorithmic advances. Specifically, we curated a novel dataset comprising 718 entries for self-docking and 1,312 entries for cross-docking; second, we incorporated 23 docking methods in three methodological categories, including physics-based methods (e.g., Schrödinger Glide), AI docking methods (e.g., DiffDock) and AI co-folding methods (e.g., AlphaFold3); third, we developed a relaxation method for post-processing to minimize conformational energy and refine binding poses; fourth, we built a leaderboard to rank submitted models in real-time. We derived some key insights and conclusions from extensive experiments: (1) AI approaches have consistently outperformed physics-based methods in overall docking success rate. (2) Most intra- and intermolecular clashes of AI approaches can be greatly alleviated with relaxation, which means combining AI modeling with physics-based post-processing could achieve excellent performance. (3) AI co-folding methods exhibit ligand chirality issues, except for Boltz-1x, which introduced physics-inspired potentials to fix hallucinations, suggesting modeling on stereochemistry improves the structural plausibility markedly. (4) Specifying binding pockets significantly promotes docking performance, indicating that pocket information can be leveraged adequately, particularly for AI co-folding methods, in future modeling efforts. The code, dataset, and leaderboard are released at https://github.com/CataAI/PoseX.

Shiji Zhao, Mengyang Wang, Shukun Xiong et al.

With the rapid development and widespread application of Large Language Models (LLMs), their potential safety risks have attracted widespread attention. Reinforcement Learning from Human Feedback (RLHF) has been adopted to enhance the safety performance of LLMs. As a simple and effective alternative to RLHF, Direct Preference Optimization (DPO) is widely used for safety alignment. However, safety alignment still suffers from severe overfitting, which limits its actual performance. This paper revisits the overfitting phenomenon from the perspective of the model's comprehension of the training data. We find that the Imbalanced Preference Comprehension phenomenon exists between responses in preference pairs, which compromises the model's safety performance. To address this, we propose Balanced Direct Preference Optimization (B-DPO), which adaptively modulates optimization strength between preferred and dispreferred responses based on mutual information. A series of experimental results show that B-DPO can enhance the safety capability while maintaining the competitive general capabilities of LLMs on various mainstream benchmarks compared to state-of-the-art methods. \color{red}{Warning: This paper contains examples of harmful texts, and reader discretion is recommended.

Bin Ren, Hang Guo, Yan Shu et al.

This paper reviews the NTIRE 2026 challenge on efficient single-image super-resolution with a focus on the proposed solutions and results. The aim of this challenge is to devise a network that reduces one or several aspects, such as runtime, parameters, and FLOPs, while maintaining PSNR of around 26.90 dB on the DIV2K_LSDIR_valid dataset, and 26.99 dB on the DIV2K_LSDIR_test dataset. The challenge had 95 registered participants, and 15 teams made valid submissions. They gauge the state-of-the-art results for efficient single-image super-resolution.

Bin Ren, Hang Guo, Lei Sun et al.

This paper presents a comprehensive review of the NTIRE 2025 Challenge on Single-Image Efficient Super-Resolution (ESR). The challenge aimed to advance the development of deep models that optimize key computational metrics, i.e., runtime, parameters, and FLOPs, while achieving a PSNR of at least 26.90 dB on the $\operatorname{DIV2K\_LSDIR\_valid}$ dataset and 26.99 dB on the $\operatorname{DIV2K\_LSDIR\_test}$ dataset. A robust participation saw \textbf{244} registered entrants, with \textbf{43} teams submitting valid entries. This report meticulously analyzes these methods and results, emphasizing groundbreaking advancements in state-of-the-art single-image ESR techniques. The analysis highlights innovative approaches and establishes benchmarks for future research in the field.

Yirui Chen, Qinyu Xiao, Jia Yi et al.

This paper explores the application of prompt engineering to enhance the performance of large language models (LLMs) in the domain of Traditional Chinese Medicine (TCM). We propose TCM-Prompt, a framework that integrates various pre-trained language models (PLMs), templates, tokenization, and verbalization methods, allowing researchers to easily construct and fine-tune models for specific TCM-related tasks. We conducted experiments on disease classification, syndrome identification, herbal medicine recommendation, and general NLP tasks, demonstrating the effectiveness and superiority of our approach compared to baseline methods. Our findings suggest that prompt engineering is a promising technique for improving the performance of LLMs in specialized domains like TCM, with potential applications in digitalization, modernization, and personalized medicine.

Mengyang Wang, Zhicong Zhang, Jiahui Li et al.

Multi-task learning (MTL) is an efficient way to improve the performance of related tasks by sharing knowledge. However, most existing MTL networks run on a single end and are not suitable for collaborative intelligence (CI) scenarios. In this work, we propose an MTL network with a deep joint source-channel coding (JSCC) framework, which allows operating under CI scenarios. We first propose a feature fusion based MTL network (FFMNet) for joint object detection and semantic segmentation. Compared with other MTL networks, FFMNet gets higher performance with fewer parameters. Then FFMNet is split into two parts, which run on a mobile device and an edge server respectively. The feature generated by the mobile device is transmitted through the wireless channel to the edge server. To reduce the transmission overhead of the intermediate feature, a deep JSCC network is designed. By combining two networks together, the whole model achieves 512x compression for the intermediate feature and a performance loss within 2% on both tasks. At last, by training with noise, the FFMNet with JSCC is robust to various channel conditions and outperforms the separate source and channel coding scheme.

Xiaomei Bai, Mengyang Wang, Ivan Lee et al.

Globally, recommendation services have become important due to the fact that they support e-commerce applications and different research communities. Recommender systems have a large number of applications in many fields including economic, education, and scientific research. Different empirical studies have shown that recommender systems are more effective and reliable than keyword-based search engines for extracting useful knowledge from massive amounts of data. The problem of recommending similar scientific articles in scientific community is called scientific paper recommendation. Scientific paper recommendation aims to recommend new articles or classical articles that match researchers' interests. It has become an attractive area of study since the number of scholarly papers increases exponentially. In this survey, we first introduce the importance and advantages of paper recommender systems. Second, we review the recommendation algorithms and methods, such as Content-Based methods, Collaborative Filtering methods, Graph-Based methods and Hybrid methods. Then, we introduce the evaluation methods of different recommender systems. Finally, we summarize open issues in the paper recommender systems, including cold start, sparsity, scalability, privacy, serendipity and unified scholarly data standards. The purpose of this survey is to provide comprehensive reviews on scholarly paper recommendation.