Guy Shani

Daniel Shats, Hadar Hezi, Guy Shani et al.

Assessing microsatellite stability status of a patient's colorectal cancer is crucial in personalizing treatment regime. Recently, convolutional-neural-networks (CNN) combined with transfer-learning approaches were proposed to circumvent traditional laboratory testing for determining microsatellite status from hematoxylin and eosin stained biopsy whole slide images (WSI). However, the high resolution of WSI practically prevent direct classification of the entire WSI. Current approaches bypass the WSI high resolution by first classifying small patches extracted from the WSI, and then aggregating patch-level classification logits to deduce the patient-level status. Such approaches limit the capacity to capture important information which resides at the high resolution WSI data. We introduce an effective approach to leverage WSI high resolution information by momentum contrastive learning of patch embeddings along with training a patient-level classifier on groups of those embeddings. Our approach achieves up to 7.4\% better accuracy compared to the straightforward patch-level classification and patient level aggregation approach with a higher stability (AUC, $0.91 \pm 0.01$ vs. $0.85 \pm 0.04$, p-value$<0.01$). Our code can be found at https://github.com/TechnionComputationalMRILab/colorectal_cancer_ai.

Shuangning Li, Lluis Salvat Niell, Sung Won Choi et al.

Mobile health aims to enhance health outcomes by delivering interventions to individuals as they go about their daily life. The involvement of care partners and social support networks often proves crucial in helping individuals managing burdensome medical conditions. This presents opportunities in mobile health to design interventions that target the dyadic relationship -- the relationship between a target person and their care partner -- with the aim of enhancing social support. In this paper, we develop dyadic RL, an online reinforcement learning algorithm designed to personalize intervention delivery based on contextual factors and past responses of a target person and their care partner. Here, multiple sets of interventions impact the dyad across multiple time intervals. The developed dyadic RL is Bayesian and hierarchical. We formally introduce the problem setup, develop dyadic RL and establish a regret bound. We demonstrate dyadic RL's empirical performance through simulation studies on both toy scenarios and on a realistic test bed constructed from data collected in a mobile health study.

Oded Blumenthal, Guy Shani

Partially observable Markov decision processes (POMDP) are a useful model for decision-making under partial observability and stochastic actions. Partially Observable Monte-Carlo Planning is an online algorithm for deciding on the next action to perform, using a Monte-Carlo tree search approach, based on the UCT (UCB applied to trees) algorithm for fully observable Markov-decision processes. POMCP develops an action-observation tree, and at the leaves, uses a rollout policy to provide a value estimate for the leaf. As such, POMCP is highly dependent on the rollout policy to compute good estimates, and hence identify good actions. Thus, many practitioners who use POMCP are required to create strong, domain-specific heuristics. In this paper, we model POMDPs as stochastic contingent planning problems. This allows us to leverage domain-independent heuristics that were developed in the planning community. We suggest two heuristics, the first is based on the well-known h_add heuristic from classical planning, and the second is computed in belief space, taking the value of information into account.

Ziping Xu, Hinal Jajal, Sung Won Choi et al.

Medication adherence is critical for the recovery of adolescents and young adults (AYAs) who have undergone hematopoietic cell transplantation (HCT). However, maintaining adherence is challenging for AYAs after hospital discharge, who experience both individual (e.g. physical and emotional symptoms) and interpersonal barriers (e.g., relational difficulties with their care partner, who is often involved in medication management). To optimize the effectiveness of a three-component digital intervention targeting both members of the dyad as well as their relationship, we propose a novel Multi-Agent Reinforcement Learning (MARL) approach to personalize the delivery of interventions. By incorporating the domain knowledge, the MARL framework, where each agent is responsible for the delivery of one intervention component, allows for faster learning compared with a flattened agent. Evaluation using a dyadic simulator environment, based on real clinical data, shows a significant improvement in medication adherence (approximately 3%) compared to purely random intervention delivery. The effectiveness of this approach will be further evaluated in an upcoming trial.

Rotem Lev Lehman, Guy Shani, Roni Stern

In collaborative privacy preserving planning (CPPP), a group of agents jointly creates a plan to achieve a set of goals while preserving each others' privacy. During planning, agents often reveal the private dependencies between their public actions to other agents, that is, which public action facilitates the preconditions of another public action. Previous work in CPPP does not limit the disclosure of such dependencies. In this paper, we explicitly limit the amount of disclosed dependencies, allowing agents to publish only a part of their private dependencies. We investigate different strategies for deciding which dependencies to publish, and how they affect the ability to find solutions. We evaluate the ability of two solvers -- distribute forward search and centralized planning based on a single-agent projection -- to produce plans under this constraint. Experiments over standard CPPP domains show that the proposed dependency-sharing strategies enable generating plans while sharing only a small fraction of all private dependencies.

Avi Segal, Kobi Gal, Guy Shani et al.

The prevalence of e-learning systems and on-line courses has made educational material widely accessible to students of varying abilities and backgrounds. There is thus a growing need to accommodate for individual differences in e-learning systems. This paper presents an algorithm called EduRank for personalizing educational content to students that combines a collaborative filtering algorithm with voting methods. EduRank constructs a difficulty ranking for each student by aggregating the rankings of similar students using different aspects of their performance on common questions. These aspects include grades, number of retries, and time spent solving questions. It infers a difficulty ranking directly over the questions for each student, rather than ordering them according to the student's predicted score. The EduRank algorithm was tested on two data sets containing thousands of students and a million records. It was able to outperform the state-of-the-art ranking approaches as well as a domain expert. EduRank was used by students in a classroom activity, where a prior model was incorporated to predict the difficulty rankings of students with no prior history in the system. It was shown to lead students to solve more difficult questions than an ordering by a domain expert, without reducing their performance.