Keyu Li

Hanxue Gu, Keyu Li, Roy J. Colglazier et al.

The assessment of knee osteoarthritis (KOA) severity on knee X-rays is a central criteria for the use of total knee arthroplasty. However, this assessment suffers from imprecise standards and a remarkably high inter-reader variability. An algorithmic, automated assessment of KOA severity could improve overall outcomes of knee replacement procedures by increasing the appropriateness of its use. We propose a novel deep learning-based five-step algorithm to automatically grade KOA from posterior-anterior (PA) views of radiographs: (1) image preprocessing (2) localization of knees joints in the image using the YOLO v3-Tiny model, (3) initial assessment of the severity of osteoarthritis using a convolutional neural network-based classifier, (4) segmentation of the joints and calculation of the joint space narrowing (JSN), and (5), a combination of the JSN and the initial assessment to determine a final Kellgren-Lawrence (KL) score. Furthermore, by displaying the segmentation masks used to make the assessment, our algorithm demonstrates a higher degree of transparency compared to typical "black box" deep learning classifiers. We perform a comprehensive evaluation using two public datasets and one dataset from our institution, and show that our algorithm reaches state-of-the art performance. Moreover, we also collected ratings from multiple radiologists at our institution and showed that our algorithm performs at the radiologist level. The software has been made publicly available at https://github.com/MaciejMazurowski/osteoarthritis-classification.

Yangxin Xu, Keyu Li, Ziqi Zhao et al.

Currently used wireless capsule endoscopy (WCE) is limited in terms of inspection time and flexibility since the capsule is passively moved by peristalsis and cannot be accurately positioned. Different methods have been proposed to facilitate active locomotion of WCE based on simultaneous magnetic actuation and localization technologies. In this work, we investigate the trajectory following problem of a robotic capsule under rotating magnetic actuation in a tubular environment, in order to realize safe, efficient and accurate inspection of the intestine at given points using wireless capsule endoscopes. Specifically, four trajectory following strategies are developed based on the PD controller, adaptive controller, model predictive controller and robust multi-stage model predictive controller. Moreover, our method takes into account the uncertainty in the intestinal environment by modeling the intestinal peristalsis and friction during the controller design. We validate our methods in simulation as well as in real-world experiments in various tubular environments, including plastic phantoms with different shapes and an ex-vivo pig colon. The results show that our approach can effectively actuate a reciprocally rotating capsule to follow a desired trajectory in complex tubular environments, thereby having the potential to enable accurate and repeatable inspection of the intestine for high-quality diagnosis.

Tao Tan, Zhang Li, Haixia Liu et al.

Bronchoscopy inspection as a follow-up procedure from the radiological imaging plays a key role in lung disease diagnosis and determining treatment plans for the patients. Doctors needs to make a decision whether to biopsy the patients timely when performing bronchoscopy. However, the doctors also needs to be very selective with biopsies as biopsies may cause uncontrollable bleeding of the lung tissue which is life-threaten. To help doctors to be more selective on biopsies and provide a second opinion on diagnosis, in this work, we propose a computer-aided diagnosis (CAD) system for lung diseases including cancers and tuberculosis (TB). The system is developed based on transfer learning. We propose a novel transfer learning method: sentential fine-tuning . Compared to traditional fine-tuning methods, our methods achieves the best performance. We obtained a overall accuracy of 77.0% a dataset of 81 normal cases, 76 tuberculosis cases and 277 lung cancer cases while the other traditional transfer learning methods achieve an accuracy of 73% and 68%. . The detection accuracy of our method for cancers, TB and normal cases are 87%, 54% and 91% respectively. This indicates that the CAD system has potential to improve lung disease diagnosis accuracy in bronchoscopy and it also might be used to be more selective with biopsies.