Julien Bert

Guillaume Sallé, Pierre-Henri Conze, Julien Bert et al.

\textit{Objectives}: Data scarcity and domain shifts lead to biased training sets that do not accurately represent deployment conditions. A related practical problem is cross-modal image segmentation, where the objective is to segment unlabelled images using previously labelled datasets from other imaging modalities. \textit{Methods}: We propose a cross-modal segmentation method based on conventional image synthesis boosted by a new data augmentation technique called Generative Blending Augmentation (GBA). GBA leverages a SinGAN model to learn representative generative features from a single training image to diversify realistically tumor appearances. This way, we compensate for image synthesis errors, subsequently improving the generalization power of a downstream segmentation model. The proposed augmentation is further combined to an iterative self-training procedure leveraging pseudo labels at each pass. \textit{Results}: The proposed solution ranked first for vestibular schwannoma (VS) segmentation during the validation and test phases of the MICCAI CrossMoDA 2022 challenge, with best mean Dice similarity and average symmetric surface distance measures. \textit{Conclusion and significance}: Local contrast alteration of tumor appearances and iterative self-training with pseudo labels are likely to lead to performance improvements in a variety of segmentation contexts.

Chi-Hieu Pham, Didier Benoit, Vincent Bourbonne et al.

We introduce a novel learning framework for accelerated Monte Carlo (MC) dose calculation termed Energy-Shifting. This approach leverages deep learning to synthesize 6 MV TrueBeam Linear Accelerator (LINAC) dose distributions directly from monoenergetic inputs under identical beam configurations. Unlike conventional denoising techniques, which rely on noisy low-count dose maps that compromise beam profile integrity, our method achieves superior cross-domain generalization on unseen datasets by integrating high-fidelity anatomical textures and source-specific beam similarity into the model's input space. Furthermore, we propose a novel 3D architecture termed TransUNetSE3D, featuring Transformer blocks for global context and Residual Squeeze-and-Excitation (SE) modules for adaptive channel-wise feature recalibration. Hierarchical representations of these blocks are fused into the network's latent space alongside the primary dose-map parameters, allowing physics-aware reconstruction. This hybrid design outperforms existing UNet and Transformer-based benchmarks in both spatial precision and structural preservation, while maintaining the execution speed necessary for real-time use. Our proposed pipeline achieves a Gamma Passing Rate exceeding 98% (3%/3mm) compared to the MC reference, evaluated within the framework of a treatment planning system (TPS) for prostate radiotherapy. These results offer a robust solution for fast volumetric dosimetry in adaptive radiotherapy.

Jing Zhang, Alexandre Bousse, Chi-Hieu Pham et al.

Targeted Radionuclide Therapy (TRT) is a modern strategy in radiation oncology that aims to administer a potent radiation dose specifically to cancer cells using cancer-targeting radiopharmaceuticals. Accurate radiation dose estimation tailored to individual patients is crucial. Deep learning, particularly with pre-therapy imaging, holds promise for personalizing TRT doses. However, current methods require large time series of SPECT imaging, which is hardly achievable in routine clinical practice, and thus raises issues of data availability. Our objective is to develop a semi-supervised learning (SSL) solution to personalize dosimetry using pre-therapy images. The aim is to develop an approach that achieves accurate results when PET/CT images are available, but are associated with only a few post-therapy dosimetry data provided by SPECT images. In this work, we introduce an SSL method using a pseudo-label generation approach for regression tasks inspired by the FixMatch framework. The feasibility of the proposed solution was preliminarily evaluated through an in-silico study using synthetic data and Monte Carlo simulation. Experimental results for organ dose prediction yielded promising outcomes, showing that the use of pseudo-labeled data provides better accuracy compared to using only labeled data.

Yi-Heng Cao, Vincent Bourbonne, François Lucia et al.

Objective: Four-dimensional computed tomography (4DCT) imaging consists in reconstructing a CT acquisition into multiple phases to track internal organ and tumor motion. It is commonly used in radiotherapy treatment planning to establish planning target volumes. However, 4DCT increases protocol complexity, may not align with patient breathing during treatment, and lead to higher radiation delivery. Approach: In this study, we propose a deep synthesis method to generate pseudo respiratory CT phases from static images for motion-aware treatment planning. The model produces patient-specific deformation vector fields (DVFs) by conditioning synthesis on external patient surface-based estimation, mimicking respiratory monitoring devices. A key methodological contribution is to encourage DVF realism through supervised DVF training while using an adversarial term jointly not only on the warped image but also on the magnitude of the DVF itself. This way, we avoid excessive smoothness typically obtained through deep unsupervised learning, and encourage correlations with the respiratory amplitude. Main results: Performance is evaluated using real 4DCT acquisitions with smaller tumor volumes than previously reported. Results demonstrate for the first time that the generated pseudo-respiratory CT phases can capture organ and tumor motion with similar accuracy to repeated 4DCT scans of the same patient. Mean inter-scans tumor center-of-mass distances and Dice similarity coefficients were $1.97$mm and $0.63$, respectively, for real 4DCT phases and $2.35$mm and $0.71$ for synthetic phases, and compares favorably to a state-of-the-art technique (RMSim).

Hussein Harb, Didier Benoit, Axel Rannou et al.

To develop a machine learning-based framework for accurately modeling the anode heel effect in Monte Carlo simulations of X-ray imaging systems, enabling realistic beam intensity profiles with minimal experimental calibration. Multiple regression models were trained to predict spatial intensity variations along the anode-cathode axis using experimentally acquired weights derived from beam measurements across different tube potentials. These weights captured the asymmetry introduced by the anode heel effect. A systematic fine-tuning protocol was established to minimize the number of required measurements while preserving model accuracy. The models were implemented in the OpenGATE 10 and GGEMS Monte Carlo toolkits to evaluate their integration feasibility and predictive performance. Among the tested models, gradient boosting regression (GBR) delivered the highest accuracy, with prediction errors remaining below 5% across all energy levels. The optimized fine-tuning strategy required only six detector positions per energy level, reducing measurement effort by 65%. The maximum error introduced through this fine-tuning process remained below 2%. Dose actor comparisons within Monte Carlo simulations demonstrated that the GBR-based model closely replicated clinical beam profiles and significantly outperformed conventional symmetric beam models. This study presents a robust and generalizable method for incorporating the anode heel effect into Monte Carlo simulations using machine learning. By enabling accurate, energy-dependent beam modeling with limited calibration data, the approach enhances simulation realism for applications in clinical dosimetry, image quality assessment, and radiation protection.

Vincent Jaouen, Pierre-Henri Conze, Guillaume Dardenne et al.

In image registration, many efforts have been devoted to the development of alternatives to the popular normalized mutual information criterion. Concurrently to these efforts, an increasing number of works have demonstrated that substantial gains in registration accuracy can also be achieved by aligning structural representations of images rather than images themselves. Following this research path, we propose a new method for mono- and multimodal image registration based on the alignment of regularized vector fields derived from structural information such as gradient vector flow fields, a technique we call \textit{vector field similarity}. Our approach can be combined in a straightforward fashion with any existing registration framework by substituting vector field similarity to intensity-based registration. In our experiments, we show that the proposed approach compares favourably with conventional image alignment on several public image datasets using a diversity of imaging modalities and anatomical locations.