Mustaffa Hussain

Mustaffa Hussain, Saharsh Barve

Functional tissue Units (FTUs) are cell population neighborhoods local to a particular organ performing its main function.The FTUs provide crucial information to the pathologist in understanding the disease affecting a particular organ by providing information at the cellular level.In our research, we have developed a model to segment multi-organ FTUs across 5 organs namely: the kidney, large intestine, lung, prostate and spleen by utilizing the 'HuBMAP + HPA - Hacking the Human Body' competition dataset.We propose adding switched auxiliary loss for training models like the transformers to overcome the diminishing gradient problem which poses a challenge towards optimal training of deep models.Overall, our model achieved a dice score of 0.793 on the public dataset and 0.778 on the private dataset.The results supports the robustness of the proposed training methodology.The findings also bolster the use of transformers models for dense prediction tasks in the field of medical image analysis.The study assists in understanding the relationships between cell and tissue organization thereby providing a useful medium to look at the impact of cellular functions on human health.

Mustaffa Hussain, Ritesh Gangnani, Sasidhar Kadiyala

Domain variability is a common bottle neck in developing generalisable algorithms for various medical applications. Motivated by the observation that the domain variability of the medical images is to some extent compact, we propose to learn a target representative feature space through unpaired image to image translation (CycleGAN). We comprehensively evaluate the performanceand usefulness by utilising the transformation to mitosis detection with candidate proposal and classification. This work presents a simple yet effective multi-step mitotic figure detection algorithm developed as a baseline for the MIDOG challenge. On the preliminary test set, the algorithm scoresan F1 score of 0.52.