Wenli Zhang

Wenli Zhang, Jiaheng Xie, Zhu Zhang et al.

Depression is a common disease worldwide. It is difficult to diagnose and continues to be underdiagnosed. Because depressed patients constantly share their symptoms, major life events, and treatments on social media, researchers are turning to user-generated digital traces on social media for depression detection. Such methods have distinct advantages in combating depression because they can facilitate innovative approaches to fight depression and alleviate its social and economic burden. However, most existing studies lack effective means to incorporate established medical domain knowledge in depression detection or suffer from feature extraction difficulties that impede greater performance. Following the design science research paradigm, we propose a Deep Knowledge-aware Depression Detection (DKDD) framework to accurately detect social media users at risk of depression and explain the critical factors that contribute to such detection. Extensive empirical studies with real-world data demonstrate that, by incorporating domain knowledge, our method outperforms existing state-of-the-art methods. Our work has significant implications for IS research in knowledge-aware machine learning, digital traces utilization, and NLP research in IS. Practically, by providing early detection and explaining the critical factors, DKDD can supplement clinical depression screening and enable large-scale evaluations of a population's mental health status.

Shaodong Wang, Qing Li, Wenli Zhang

Effectively representing medical concepts and patients is important for healthcare analytical applications. Representing medical concepts for healthcare analytical tasks requires incorporating medical domain knowledge and prior information from patient description data. Current methods, such as feature engineering and mapping medical concepts to standardized terminologies, have limitations in capturing the dynamic patterns from patient description data. Other embedding-based methods have difficulties in incorporating important medical domain knowledge and often require a large amount of training data, which may not be feasible for most healthcare systems. Our proposed framework, MD-Manifold, introduces a novel approach to medical concept and patient representation. It includes a new data augmentation approach, concept distance metric, and patient-patient network to incorporate crucial medical domain knowledge and prior data information. It then adapts manifold learning methods to generate medical concept-level representations that accurately reflect medical knowledge and patient-level representations that clearly identify heterogeneous patient cohorts. MD-Manifold also outperforms other state-of-the-art techniques in various downstream healthcare analytical tasks. Our work has significant implications in information systems research in representation learning, knowledge-driven machine learning, and using design science as middle-ground frameworks for downstream explorative and predictive analyses. Practically, MD-Manifold has the potential to create effective and generalizable representations of medical concepts and patients by incorporating medical domain knowledge and prior data information. It enables deeper insights into medical data and facilitates the development of new analytical applications for better healthcare outcomes.

Dali Zhu, Wenli Zhang, Hualin Zeng et al.

Remote photoplethysmography (rPPG) technique extracts blood volume pulse (BVP) signals from subtle pixel changes in video frames. This study introduces rFaceNet, an advanced rPPG method that enhances the extraction of facial BVP signals with a focus on facial contours. rFaceNet integrates identity-specific facial contour information and eliminates redundant data. It efficiently extracts facial contours from temporally normalized frame inputs through a Temporal Compressor Unit (TCU) and steers the model focus to relevant facial regions by using the Cross-Task Feature Combiner (CTFC). Through elaborate training, the quality and interpretability of facial physiological signals extracted by rFaceNet are greatly improved compared to previous methods. Moreover, our novel approach demonstrates superior performance than SOTA methods in various heart rate estimation benchmarks.

Haoxin Liu, Wenli Zhang, Jiaheng Xie et al.

This study harnesses state-of-the-art AI technology for detecting mental disorders through user-generated textual content. Existing studies typically rely on fully supervised machine learning, which presents challenges such as the labor-intensive manual process of annotating extensive training data for each research problem and the need to design specialized deep learning architectures for each task. We propose a novel method to address these challenges by leveraging large language models and continuous multi-prompt engineering, which offers two key advantages: (1) developing personalized prompts that capture each user's unique characteristics and (2) integrating structured medical knowledge into prompts to provide context for disease detection and facilitate predictive modeling. We evaluate our method using three widely prevalent mental disorders as research cases. Our method significantly outperforms existing methods, including feature engineering, architecture engineering, and discrete prompt engineering. Meanwhile, our approach demonstrates success in few-shot learning, i.e., requiring only a minimal number of training examples. Moreover, our method can be generalized to other rare mental disorder detection tasks with few positive labels. In addition to its technical contributions, our method has the potential to enhance the well-being of individuals with mental disorders and offer a cost-effective, accessible alternative for stakeholders beyond traditional mental disorder screening methods.