Thanh Le

Nguyen Tuan, Phi Nguyen, Dai Tran et al.

Early detection and localization of myocardial infarction (MI) can reduce the severity of cardiac damage through timely treatment interventions. In recent years, deep learning techniques have shown promise for detecting MI in echocardiographic images. However, there has been no examination of how segmentation accuracy affects MI classification performance and the potential benefits of using ensemble learning approaches. Our study investigates this relationship and introduces a robust method that combines features from multiple segmentation models to improve MI classification performance by leveraging ensemble learning. Our method combines myocardial segment displacement features from multiple segmentation models, which are then input into a typical classifier to estimate the risk of MI. We validated the proposed approach on two datasets: the public HMC-QU dataset (109 echocardiograms) for training and validation, and an E-Hospital dataset (60 echocardiograms) from a local clinical site in Vietnam for independent testing. Model performance was evaluated based on accuracy, sensitivity, and specificity. The proposed approach demonstrated excellent performance in detecting MI. The results showed that the proposed approach outperformed the state-of-the-art feature-based method. Further research is necessary to determine its potential use in clinical settings as a tool to assist cardiologists and technicians with objective assessments and reduce dependence on operator subjectivity. Our research codes are available on GitHub at https://github.com/vinuni-vishc/mi-detection-echo.

Thanh Le, Vasant Honavar

The Dynamical Gaussian Process Latent Variable Models provide an elegant non-parametric framework for learning the low dimensional representations of the high-dimensional time-series. Real world observational studies, however, are often ill-conditioned: the observations can be noisy, not assuming the luxury of relatively complete and equally spaced like those in time series. Such conditions make it difficult to learn reasonable representations in the high dimensional longitudinal data set by way of Gaussian Process Latent Variable Model as well as other dimensionality reduction procedures. In this study, we approach the inference of Gaussian Process Dynamical Systems in Longitudinal scenario by augmenting the bound in the variational approximation to include systematic samples of the unseen observations. We demonstrate the usefulness of this approach on synthetic as well as the human motion capture data set.