Nikos Chrisochoides

Leonidas Zimianitis, Pasindu Thenahandi, Kai Buckhalter et al.

Tracking the dynamics of non-canonical biological systems in microscopy videos remains a persistent challenge. Both classical and learning-based trackers depend on expert-reviewed data to be evaluated and adapted, yet exhaustive manual annotation rarely scales to the videos where these tools are needed most. We developed RIPPLE (Refinement Interpolation Platform for Point Location Estimation), which recasts annotation as sparse correction: a user clicks a starting point, RIPPLE proposes a full trajectory, and the user intervenes only where the trajectory drifts. We tested RIPPLE on five challenging microscopy datasets from our laboratories, four from the transparent jellyfish Clytia hemisphaerica and one tracking landmarks on rapidly moving sperm. Across these, RIPPLE matched the quality of exhaustive manual annotation while reducing manual clicks by 3 to 25 times across datasets. RIPPLE thereby fills a missing layer between manual annotation and fully automated tracking, enabling immediate quantification of biological dynamics, method benchmarking, and the production of the gold-standard data needed to adapt future automated microscopy trackers.

Iizalaarab Elhaimeur, Nikos Chrisochoides

Quantum computing instructors face a compounding problem: the concepts are counterintuitive, the mathematical formalism is dense, and qualified faculty are scarce outside a small number of well-resourced institutions. Our prior work introduced a knowledge-graph-augmented tutoring prototype with two specialized LLM agents: a Teaching Agent for dynamic interaction and a Lesson Planning Agent for lesson generation. Validated on simulated runs rather than in a real course, that prototype left open whether more aggressive agent specialization would be needed to handle the full range of quantum education tasks under real student load. This paper answers the three questions that the prototype could not answer. Can agent specialization solve the reliability problem in a domain as technically demanding as quantum information science? Can the system run in a real course, not a demonstration? Does the instructor gain actionable intelligence from the deployment? We present ITAS (Intelligent Teaching Assistant System), a multi-agent tutoring system built around four contributions: a five-module QIS curriculum grounded in Watrous's information-first framework, a Spoke-and-Wheel teaching architecture with quantum-specialized agents, a cloud infrastructure designed for production use and regulatory compliance, and a conversational analytics layer for instructors and content developers. Piloted in a quantum computing course at Old Dominion University, the system supports all three answers: deployment evidence is consistent with specialization addressing the task-boundary failures observed in the prototype, cloud infrastructure supports classroom-scale concurrency at sub-textbook cost, and the analytics agent surfaces curriculum gaps the instructor could not otherwise see.

Iizalaarab Elhaimeur, Nikos Chrisochoides

Large language model tutors are easy to build in a notebook and hard to run in a real course. We describe ITAS (Intelligent Teaching Assistant System), a multi-agent tutoring system that a graduate quantum computing course used for a semester at Old Dominion University. The system has three layers. The teaching layer is a Spoke-and-Wheel of three parallel specialist agents (Video, Code, Guidance) followed by a Synthesizer, plus a separate autograder that evaluates both the correctness and the approach of checkpoint submissions. The operational layer is four Cloud Run microservices with session state in Cloud SQL and interaction events streamed through Pub/Sub to BigQuery. The feedback layer is a narrow-scope conversational agent that answers instructor questions over per-lesson pseudonymized event streams, addressing what we call the Blind Instructor Problem: LLM tutors accumulate more data about students than the instructor can reach through routine channels. The architecture is a direct response to specific failures of an earlier prototype, and we describe which of those fixes carried forward and which were dropped for this iteration. We report on a pilot deployment (five students, one course, one semester) interpreted as system-behavior evidence rather than learning-outcome evidence: the teaching layer handled 334 chat turns without the task-boundary hallucinations that domain consolidation would have risked, the operational layer captured 10,628 events across five modules, and the feedback layer surfaced two findings the instructor acted on mid-semester. We do not claim the pilot generalizes. We do claim that the system as described is one workable answer to the question of what an LLM-based ITS needs to look like end-to-end to run in a real course.

Iizalaarab Elhaimeur, Nikos Chrisochoides

Multi-agent LLM tutoring systems improve response quality through agent specialization, but each student query triggers several concurrent API calls whose latencies compound through a parallel-phase maximum effect that single-agent systems do not face. We instrument ITAS, a four-agent tutoring system built on Gemini 2.5 Flash and Google Vertex AI, across three throughput tiers (Standard PayGo, Priority PayGo, and Provisioned Throughput) and eleven concurrency levels up to 50 simultaneous users, producing over 3,000 requests drawn from a live graduate STEM deployment. Priority PayGo maintains flat sub-4-second response times across the full load range; Standard PayGo degrades substantially under classroom-scale concurrency; and Provisioned Throughput delivers the lowest latency at low concurrency but saturates its reserved capacity above approximately 20 concurrent users. Cost analysis places both pay-per-token tiers well below the price of a STEM textbook per student per semester under a worst-case usage ceiling. Provisioned Throughput, expensive under continuous provisioning, becomes cost-competitive for institutions that can predict and concentrate their traffic toward high utilization. These results provide concrete tier-selection guidance across deployment scales from a single seminar to a university-wide rollout.

Dominik Soós, Marc Paterno, John Stenger et al.

Optimization problems become fundamentally challenging as the number of variables increases. Because the volume of the search space grows exponentially, classical algorithms frequently fail to locate the global minimum of non-convex functions. While quantum optimization offers a potential alternative, mapping continuous problems onto near-term quantum hardware introduces severe scaling limits and barren plateaus. To bridge this gap, we propose the Distributed Quantum-Enhanced Optimization (D-QEO) framework. Instead of forcing the quantum processor to find the exact minimum, we use it simply as a topographical preconditioner. The QPU maps the landscape to locate the most promising basin of attraction, generating high-quality seed points for a classical GPU-accelerated solver to refine. To make this approach viable for utility-scale problems, we exploit the mathematical structure of separable functions. This allows us to cut a 50-qubit (i.e., $2^{50}$) global search space into independent and manageable sub-spaces using 5-qubit subcircuits. By executing these fragments concurrently with CUDA-Q, we completely bypass the overhead of cross-register entanglement and classical tensor knitting for separable functions. Benchmarks on the 10-dimensional Rastrigin and Ackley functions show that D-QEO prevents the exponential failure rates observed in purely classical algorithms. Furthermore, this quantum warm-start significantly reduces the number of classical BFGS iterations required to converge, providing a highly practical blueprint for utilizing near-term quantum resources in complex global search.

Steven Owen, Nathan Brown, Nikos Chrisochoides et al.

Artificial intelligence is beginning to reduce the manual effort in the CAD-to-mesh pipeline. Written for meshing and geometry practitioners with limited AI background, this survey organizes recent work by workflow step. We cover part classification and segmentation, mesh quality prediction, and defeaturing. We review AI guidance for unstructured meshing, block-structured meshing in 2D and 3D, and volumetric parameterization, including reconstruction from implicit or sampled geometry. We also discuss parallel mesh generation and scripting automation via reinforcement learning and large language models. Across these topics, AI complements established geometry and meshing algorithms rather than replacing them. We conclude with practical lessons and open challenges in data, benchmarks, and trustworthy integration.

Iizalaarab Elhaimeur, Nikos Chrisochoides

Quantum computing education faces significant challenges due to its complexity and the limitations of current tools; this paper introduces a novel Intelligent Teaching Assistant for quantum computing education and details its evolutionary design process. The system combines a knowledge-graph-augmented architecture with two specialized Large Language Model (LLM) agents: a Teaching Agent for dynamic interaction, and a Lesson Planning Agent for lesson plan generation. The system is designed to adapt to individual student needs, with interactions meticulously tracked and stored in a knowledge graph. This graph represents student actions, learning resources, and relationships, aiming to enable reasoning about effective learning pathways. We describe the implementation of the system, highlighting the challenges encountered and the solutions implemented, including introducing a dual-agent architecture where tasks are separated, all coordinated through a central knowledge graph that maintains system awareness, and a user-facing tag system intended to mitigate LLM hallucination and improve user control. Preliminary results illustrate the system's potential to capture rich interaction data, dynamically adapt lesson plans based on student feedback via a tag system in simulation, and facilitate context-aware tutoring through the integrated knowledge graph, though systematic evaluation is required.

Polykarpos Thomadakis, Angelos Angelopoulos, Gagik Gavalian et al.

Particle track reconstruction is the most computationally intensive process in nuclear physics experiments. Traditional algorithms use a combinatorial approach that exhaustively tests track measurements ("hits") to identify those that form an actual particle trajectory. In this article, we describe the development of four machine learning (ML) models that assist the tracking algorithm by identifying valid track candidates from the measurements in drift chambers. Several types of machine learning models were tested, including: Convolutional Neural Networks (CNN), Multi-Layer Perceptrons (MLP), Extremely Randomized Trees (ERT) and Recurrent Neural Networks (RNN). As a result of this work, an MLP network classifier was implemented as part of the CLAS12 reconstruction software to provide the tracking code with recommended track candidates. The resulting software achieved accuracy of greater than 99\% and resulted in an end-to-end speedup of 35\% compared to existing algorithms.