Benjamin Risse

Jenna Kline, Kilian Meier, Vandita Shukla et al.

Animal ecology data collection using drones represents a substantial investment of time, expertise, and financial resources. Yet most existing datasets serve only a single research community, limiting interdisciplinary reuse. We propose a unified drone dataset standard, FAIR^2 Drones, that bridges ecology, robotics, and computer vision by building on existing FAIR and AI-ready data frameworks while adding essential platform metadata and annotation specifications. Our standard enables datasets to simultaneously support ecological analysis, robotics algorithm development, and computer vision benchmarking. We provide open-source validation tools, reference implementations, and multimodal extensions linking drone imagery with complementary sensors such as camera traps, GPS, and acoustics. By standardizing metadata across disciplines, this framework maximizes the scientific return on investment for costly field deployments and accelerates cross-domain collaboration in environmental monitoring.

Lukas Fisch, Nils R. Winter, Janik Goltermann et al.

Voxel-based Morphometry (VBM) has emerged as a powerful approach in neuroimaging research, utilized in over 7,000 studies since the year 2000. Using Magnetic Resonance Imaging (MRI) data, VBM assesses variations in the local density of brain tissue and examines its associations with biological and psychometric variables. Here, we present deepmriprep, a neural network-based pipeline that performs all necessary preprocessing steps for VBM analysis of T1-weighted MR images using deep neural networks. Utilizing the Graphics Processing Unit (GPU), deepmriprep is 37 times faster than CAT12, the leading VBM preprocessing toolbox. The proposed method matches CAT12 in accuracy for tissue segmentation and image registration across more than 100 datasets and shows strong correlations in VBM results. Tissue segmentation maps from deepmriprep have over 95% agreement with ground truth maps, and its non-linear registration, using supervised SYMNet, predicts smooth deformation fields comparable to CAT12. The high processing speed of deepmriprep enables rapid preprocessing of extensive datasets and thereby fosters the application of VBM analysis to large-scale neuroimaging studies and opens the door to real-time applications. Finally, deepmripreps straightforward, modular design enables researchers to easily understand, reuse, and advance the underlying methods, fostering further advancements in neuroimaging research. deepmriprep can be conveniently installed as a Python package and is publicly accessible at https://github.com/wwu-mmll/deepmriprep.

Lukas Fisch, Stefan Zumdick, Carlotta Barkhau et al.

Brain extraction in magnetic resonance imaging (MRI) data is an important segmentation step in many neuroimaging preprocessing pipelines. Image segmentation is one of the research fields in which deep learning had the biggest impact in recent years enabling high precision segmentation with minimal compute. Consequently, traditional brain extraction methods are now being replaced by deep learning-based methods. Here, we used a unique dataset comprising 568 T1-weighted (T1w) MR images from 191 different studies in combination with cutting edge deep learning methods to build a fast, high-precision brain extraction tool called deepbet. deepbet uses LinkNet, a modern UNet architecture, in a two stage prediction process. This increases its segmentation performance, setting a novel state-of-the-art performance during cross-validation with a median Dice score (DSC) of 99.0% on unseen datasets, outperforming current state of the art models (DSC = 97.8% and DSC = 97.9%). While current methods are more sensitive to outliers, resulting in Dice scores as low as 76.5%, deepbet manages to achieve a Dice score of > 96.9% for all samples. Finally, our model accelerates brain extraction by a factor of ~10 compared to current methods, enabling the processing of one image in ~2 seconds on low level hardware.

Jan Ernsting, Nils R. Winter, Ramona Leenings et al.

The brain-age gap is one of the most investigated risk markers for brain changes across disorders. While the field is progressing towards large-scale models, recently incorporating uncertainty estimates, no model to date provides the single-subject risk assessment capability essential for clinical application. In order to enable the clinical use of brain-age as a biomarker, we here combine uncertainty-aware deep Neural Networks with conformal prediction theory. This approach provides statistical guarantees with respect to single-subject uncertainty estimates and allows for the calculation of an individual's probability for accelerated brain-aging. Building on this, we show empirically in a sample of N=16,794 participants that 1. a lower or comparable error as state-of-the-art, large-scale brain-age models, 2. the statistical guarantees regarding single-subject uncertainty estimation indeed hold for every participant, and 3. that the higher individual probabilities of accelerated brain-aging derived from our model are associated with Alzheimer's Disease, Bipolar Disorder and Major Depressive Disorder.

Joy T Wu, Daniel Beckmann, Sarah Miller et al.

[18F]FDG-PET/CT is a cornerstone imaging modality for tumor staging and treatment response assessment across many cancer types, yet expert reader shortages necessitate more efficient diagnostic aids. While standalone AI models for automatic lesion segmentation exist, clinical translation remains hindered by concerns about interpretability, explainability, reliability, and workflow integration. We present GazeXPErT, a 4D eye-tracking dataset capturing expert search patterns during tumor detection and measurement on 346 FDG-PET/CT scans. Each study was read by a trainee and a board-certified nuclear medicine or radiology specialist using an eye-tracking-enabled annotation platform that simulates routine clinical reads. From 3,948 minutes of raw 60Hz eye-tracking data, 9,030 unique gaze-to-lesion trajectories were extracted, synchronized with PET/CT image slices, and rendered in COCO-style format for multiple machine learning applications. Baseline validation experiments demonstrate that a 3D nnUNet tumor segmentation model achieved superior performance when incorporating expert gaze patterns versus without (DICE score 0.6819 versus 0.6008), and that vision transformers trained on sequential gaze and PET/CT images can improve dynamic lesion localization (74.95% predicted gaze point closer to tumor) and expert intention prediction (Accuracy 67.53% and AUROC 0.747). GazeXPErT is a valuable resource designed to explore multiple machine learning problems beyond these baseline experiments, which include and are not limited to, visual grounding or causal reasoning, clinically explainable feature augmentation, human-computer interaction, human intention prediction or understanding, and expert gaze-rewarded modeling approaches to AI in oncologic FDG-PET/CT imaging.

Simon Boeder, Fabian Gigengack, Benjamin Risse

The 3D occupancy estimation task has become an important challenge in the area of vision-based autonomous driving recently. However, most existing camera-based methods rely on costly 3D voxel labels or LiDAR scans for training, limiting their practicality and scalability. Moreover, most methods are tied to a predefined set of classes which they can detect. In this work we present a novel approach for open vocabulary occupancy estimation called LangOcc, that is trained only via camera images, and can detect arbitrary semantics via vision-language alignment. In particular, we distill the knowledge of the strong vision-language aligned encoder CLIP into a 3D occupancy model via differentiable volume rendering. Our model estimates vision-language aligned features in a 3D voxel grid using only images. It is trained in a self-supervised manner by rendering our estimations back to 2D space, where ground-truth features can be computed. This training mechanism automatically supervises the scene geometry, allowing for a straight-forward and powerful training method without any explicit geometry supervision. LangOcc outperforms LiDAR-supervised competitors in open vocabulary occupancy by a large margin, solely relying on vision-based training. We also achieve state-of-the-art results in self-supervised semantic occupancy estimation on the Occ3D-nuScenes dataset, despite not being limited to a specific set of categories, thus demonstrating the effectiveness of our proposed vision-language training.

Marlon Becker, Frederick Altrock, Benjamin Risse

The recently proposed optimization algorithm for deep neural networks Sharpness Aware Minimization (SAM) suggests perturbing parameters before gradient calculation by a gradient ascent step to guide the optimization into parameter space regions of flat loss. While significant generalization improvements and thus reduction of overfitting could be demonstrated, the computational costs are doubled due to the additionally needed gradient calculation, making SAM unfeasible in case of limited computationally capacities. Motivated by Nesterov Accelerated Gradient (NAG) we propose Momentum-SAM (MSAM), which perturbs parameters in the direction of the accumulated momentum vector to achieve low sharpness without significant computational overhead or memory demands over SGD or Adam. We evaluate MSAM in detail and reveal insights on separable mechanisms of NAG, SAM and MSAM regarding training optimization and generalization. Code is available at https://github.com/MarlonBecker/MSAM.

Leon Pielage, Ole Hätscher, Mitja Back et al.

The inability of Large Language Models (LLMs) to modulate their personality expression in response to evolving dialogue dynamics hinders their performance in complex, interactive contexts. We propose a model-agnostic framework for dynamic personality simulation that employs state machines to represent latent personality states, where transition probabilities are dynamically adapted to the conversational context. Part of our architecture is a modular pipeline for continuous personality scoring that evaluates dialogues along latent axes while remaining agnostic to the specific personality models, their dimensions, transition mechanisms, or LLMs used. These scores function as dynamic state variables that systematically reconfigure the system prompt, steering behavioral alignment throughout the interaction.We evaluate this framework by operationalizing the Interpersonal Circumplex (IPC) in a medical education setting. Results demonstrate that the system successfully adapts its personality state to user inputs, but also influences user behavior, thereby facilitating de-escalation training. Notably, the scoring pipeline maintains comparable precision even when utilizing lightweight, fine-tuned classifiers instead of large-scale LLMs. This work demonstrates the feasibility of modular, personality-adaptive architectures for education, customer support, and broader human-computer interaction.

Christian Porschen, Jan Ernsting, Paul Brauckmann et al.

Acute Kidney Injury (AKI) is a frequent complication in critically ill patients, affecting up to 50% of patients in the intensive care units. The lack of standardized and open-source tools for applying the Kidney Disease Improving Global Outcomes (KDIGO) criteria to time series data has a negative impact on workload and study quality. This project introduces pyAKI, an open-source pipeline addressing this gap by providing a comprehensive solution for consistent KDIGO criteria implementation. The pyAKI pipeline was developed and validated using a subset of the Medical Information Mart for Intensive Care (MIMIC)-IV database, a commonly used database in critical care research. We defined a standardized data model in order to ensure reproducibility. Validation against expert annotations demonstrated pyAKI's robust performance in implementing KDIGO criteria. Comparative analysis revealed its ability to surpass the quality of human labels. This work introduces pyAKI as an open-source solution for implementing the KDIGO criteria for AKI diagnosis using time series data with high accuracy and performance.

Vandita Shukla, Fabio Remondino, Benjamin Risse

Monocular imaging of animals inherently reduces 3D structures to 2D projections. Detection algorithms lead to 2D bounding boxes that lack information about animal's orientation relative to the camera. To build 3D detection methods for RGB animal images, there is a lack of labeled datasets; such labeling processes require 3D input streams along with RGB data. We present a pipeline that utilises Skinned Multi Animal Linear models to estimate 3D bounding boxes and to project them as robust labels into 2D image space using a dedicated camera pose refinement algorithm. To assess which sides of the animal are captured, cuboid face visibility metrics are computed. These 3D bounding boxes and metrics form a crucial step toward developing and benchmarking future monocular 3D animal detection algorithms. We evaluate our method on the Animal3D dataset, demonstrating accurate performance across species and settings.

Simon Boeder, Fabian Gigengack, Benjamin Risse

Semantic occupancy has recently gained significant traction as a prominent 3D scene representation. However, most existing methods rely on large and costly datasets with fine-grained 3D voxel labels for training, which limits their practicality and scalability, increasing the need for self-monitored learning in this domain. In this work, we present a novel approach to occupancy estimation inspired by neural radiance field (NeRF) using only 2D labels, which are considerably easier to acquire. In particular, we employ differentiable volumetric rendering to predict depth and semantic maps and train a 3D network based on 2D supervision only. To enhance geometric accuracy and increase the supervisory signal, we introduce temporal rendering of adjacent time steps. Additionally, we introduce occupancy flow as a mechanism to handle dynamic objects in the scene and ensure their temporal consistency. Through extensive experimentation we demonstrate that 2D supervision only is sufficient to achieve state-of-the-art performance compared to methods using 3D labels, while outperforming concurrent 2D approaches. When combining 2D supervision with 3D labels, temporal rendering and occupancy flow we outperform all previous occupancy estimation models significantly. We conclude that the proposed rendering supervision and occupancy flow advances occupancy estimation and further bridges the gap towards self-supervised learning in this domain.

Vandita Shukla, Fabio Remondino, Blair Costelloe et al.

Monocular RGB cameras mounted on drones are widely used for wildlife monitoring, yet most analytical pipelines remain confined to two-dimensional image space, leaving geometric information in video underexploited. We present WildLIFT, a computational framework that integrates three-dimensional scene geometry from monocular drone video with open-vocabulary 2D instance segmentation to enable species-agnostic 3D detection and tracking. Oriented 3D bounding box labels with semantic face information enable quantitative assessment of viewpoint coverage and inter-animal occlusion, producing structured metadata for downstream ecological analyses. We validate the framework on 2,581 manually curated frames comprising over 6,700 3D detections across four large mammal species. WildLIFT maintains high identity consistency in multi-animal scenes and substantially reduces manual 3D annotation effort through keyframe-based refinement. By transforming standard drone footage into structured 3D and viewpoint-aware representations, WildLIFT extends the analytical utility of aerial wildlife datasets for behavioural research and population monitoring.

Simon Boeder, Fabian Gigengack, Benjamin Risse

Occupancy estimation has become a prominent task in 3D computer vision, particularly within the autonomous driving community. In this paper, we present a novel approach to occupancy estimation, termed GaussianFlowOcc, which is inspired by Gaussian Splatting and replaces traditional dense voxel grids with a sparse 3D Gaussian representation. Our efficient model architecture based on a Gaussian Transformer significantly reduces computational and memory requirements by eliminating the need for expensive 3D convolutions used with inefficient voxel-based representations that predominantly represent empty 3D spaces. GaussianFlowOcc effectively captures scene dynamics by estimating temporal flow for each Gaussian during the overall network training process, offering a straightforward solution to a complex problem that is often neglected by existing methods. Moreover, GaussianFlowOcc is designed for scalability, as it employs weak supervision and does not require costly dense 3D voxel annotations based on additional data (e.g., LiDAR). Through extensive experimentation, we demonstrate that GaussianFlowOcc significantly outperforms all previous methods for weakly supervised occupancy estimation on the nuScenes dataset while featuring an inference speed that is 50 times faster than current SOTA.

Marlon Becker, Benjamin Risse

We empirically investigate the impact of learning randomly generated labels in parallel to class labels in supervised learning on memorization, model complexity, and generalization in deep neural networks. To this end, we introduce a multi-head network architecture as an extension of standard CNN architectures. Inspired by methods used in fair AI, our approach allows for the unlearning of random labels, preventing the network from memorizing individual samples. Based on the concept of Rademacher complexity, we first use our proposed method as a complexity metric to analyze the effects of common regularization techniques and challenge the traditional understanding of feature extraction and classification in CNNs. Second, we propose a novel regularizer that effectively reduces sample memorization. However, contrary to the predictions of classical statistical learning theory, we do not observe improvements in generalization.

Daniel Beckmann, Benjamin Risse

Expert eye movements provide a rich, passive source of domain knowledge in radiology, offering a powerful cue for integrating diagnostic reasoning into computer-aided analysis. However, direct integration into CNN-based systems, which historically have dominated the medical image analysis domain, is challenging: gaze recordings are sequential, temporally dense yet spatially sparse, noisy, and variable across experts. As a consequence, most existing image-based models utilize reduced representations such as heatmaps. In contrast, gaze naturally aligns with transformer architectures, as both are sequential in nature and rely on attention to highlight relevant input regions. In this work, we introduce FixationFormer, a transformer-based architecture that represents expert gaze trajectories as sequences of tokens, thereby preserving their temporal and spatial structure. By modeling gaze sequences jointly with image features, our approach addresses sparsity and variability in gaze data while enabling a more direct and fine-grained integration of expert diagnostic cues through explicit cross-attention between the image and gaze token sequences. We evaluate our method on three publicly available benchmark chest X-ray datasets and demonstrate that it achieves state-of-the-art classification performance, highlighting the value of representing gaze as a sequence in transformer-based medical image analysis.

Simon Boeder, Fabian Gigengack, Simon Roesler et al.

Recent progress in self- and weakly supervised occupancy estimation has largely relied on 2D projection or rendering-based supervision, which suffers from geometric inconsistencies and severe depth bleeding. We thus introduce ShelfOcc, a vision-only method that overcomes these limitations without relying on LiDAR. ShelfOcc brings supervision into native 3D space by generating metrically consistent semantic voxel labels from video, enabling true 3D supervision without any additional sensors or manual 3D annotations. While recent vision-based 3D geometry foundation models provide a promising source of prior knowledge, they do not work out of the box as a prediction due to sparse or noisy and inconsistent geometry, especially in dynamic driving scenes. Our method introduces a dedicated framework that mitigates these issues by filtering and accumulating static geometry consistently across frames, handling dynamic content and propagating semantic information into a stable voxel representation. This data-centric shift in supervision for weakly/shelf-supervised occupancy estimation allows the use of essentially any SOTA occupancy model architecture without relying on LiDAR data. We argue that such high-quality supervision is essential for robust occupancy learning and constitutes an important complementary avenue to architectural innovation. On the Occ3D-nuScenes benchmark, ShelfOcc substantially outperforms all previous weakly/shelf-supervised methods (up to a 34% relative improvement), establishing a new data-driven direction for LiDAR-free 3D scene understanding.

Julian Bigge, Maite Ogueta, Luis Garcia et al.

In this paper we propose the Hatching-Box, a novel imaging and analysis system to automatically monitor and quantify the developmental behavior of Drosophila in standard rearing vials and during regular rearing routines, rendering explicit experiments obsolete. This is achieved by combining custom tailored imaging hardware with dedicated detection and tracking algorithms, enabling the quantification of larvae, filled/empty pupae and flies over multiple days. Given the affordable and reproducible design of the Hatching-Box in combination with our generic client/server-based software, the system can easily be scaled to monitor an arbitrary amount of rearing vials simultaneously. We evaluated our system on a curated image dataset comprising nearly 470,000 annotated objects and performed several studies on real world experiments. We successfully reproduced results from well-established circadian experiments by comparing the eclosion periods of wild type flies to the clock mutants $\textit{per}^{short}$, $\textit{per}^{long}$ and $\textit{per}^0$ without involvement of any manual labor. Furthermore we show, that the Hatching-Box is able to extract additional information about group behavior as well as to reconstruct the whole life-cycle of the individual specimens. These results not only demonstrate the applicability of our system for long-term experiments but also indicate its benefits for automated monitoring in the general cultivation process.

Jan Ernsting, Phillip Nikolas Beeken, Lynn Ogoniak et al.

Testis size is known to be one of the main predictors of male fertility, usually assessed in clinical workup via palpation or imaging. Despite its potential, population-level evaluation of testicular volume using imaging remains underexplored. Previous studies, limited by small and biased datasets, have demonstrated the feasibility of machine learning for testis volume segmentation. This paper presents an evaluation of segmentation methods for testicular volume using Magnet Resonance Imaging data from the UKBiobank. The best model achieves a median dice score of $0.87$, compared to median dice score of $0.83$ for human interrater reliability on the same dataset, enabling large-scale annotation on a population scale for the first time. Our overall aim is to provide a trained model, comparative baseline methods, and annotated training data to enhance accessibility and reproducibility in testis MRI segmentation research.

Devis Tuia, Benjamin Kellenberger, Sara Beery et al.

Data acquisition in animal ecology is rapidly accelerating due to inexpensive and accessible sensors such as smartphones, drones, satellites, audio recorders and bio-logging devices. These new technologies and the data they generate hold great potential for large-scale environmental monitoring and understanding, but are limited by current data processing approaches which are inefficient in how they ingest, digest, and distill data into relevant information. We argue that machine learning, and especially deep learning approaches, can meet this analytic challenge to enhance our understanding, monitoring capacity, and conservation of wildlife species. Incorporating machine learning into ecological workflows could improve inputs for population and behavior models and eventually lead to integrated hybrid modeling tools, with ecological models acting as constraints for machine learning models and the latter providing data-supported insights. In essence, by combining new machine learning approaches with ecological domain knowledge, animal ecologists can capitalize on the abundance of data generated by modern sensor technologies in order to reliably estimate population abundances, study animal behavior and mitigate human/wildlife conflicts. To succeed, this approach will require close collaboration and cross-disciplinary education between the computer science and animal ecology communities in order to ensure the quality of machine learning approaches and train a new generation of data scientists in ecology and conservation.

Tim Hahn, Jan Ernsting, Nils R. Winter et al.

The deviation between chronological age and age predicted from neuroimaging data has been identified as a sensitive risk-marker of cross-disorder brain changes, growing into a cornerstone of biological age-research. However, Machine Learning models underlying the field do not consider uncertainty, thereby confounding results with training data density and variability. Also, existing models are commonly based on homogeneous training sets, often not independently validated, and cannot be shared due to data protection issues. Here, we introduce an uncertainty-aware, shareable, and transparent Monte-Carlo Dropout Composite-Quantile-Regression (MCCQR) Neural Network trained on N=10,691 datasets from the German National Cohort. The MCCQR model provides robust, distribution-free uncertainty quantification in high-dimensional neuroimaging data, achieving lower error rates compared to existing models across ten recruitment centers and in three independent validation samples (N=4,004). In two examples, we demonstrate that it prevents spurious associations and increases power to detect accelerated brain-aging. We make the pre-trained model publicly available.

Karim Huesmann, Luis Garcia Rodriguez, Lars Linsen et al.

Overfitting is one of the fundamental challenges when training convolutional neural networks and is usually identified by a diverging training and test loss. The underlying dynamics of how the flow of activations induce overfitting is however poorly understood. In this study we introduce a perplexity-based sparsity definition to derive and visualise layer-wise activation measures. These novel explainable AI strategies reveal a surprising relationship between activation sparsity and overfitting, namely an increase in sparsity in the feature extraction layers shortly before the test loss starts rising. This tendency is preserved across network architectures and reguralisation strategies so that our measures can be used as a reliable indicator for overfitting while decoupling the network's generalisation capabilities from its loss-based definition. Moreover, our differentiable sparsity formulation can be used to explicitly penalise the emergence of sparsity during training so that the impact of reduced sparsity on overfitting can be studied in real-time. Applying this penalty and analysing activation sparsity for well known regularisers and in common network architectures supports the hypothesis that reduced activation sparsity can effectively improve the generalisation and classification performance. In line with other recent work on this topic, our methods reveal novel insights into the contradicting concepts of activation sparsity and network capacity by demonstrating that dense activations can enable discriminative feature learning while efficiently exploiting the capacity of deep models without suffering from overfitting, even when trained excessively.

Lukas Fisch, Jan Ernsting, Nils R. Winter et al.

Age prediction based on Magnetic Resonance Imaging (MRI) data of the brain is a biomarker to quantify the progress of brain diseases and aging. Current approaches rely on preparing the data with multiple preprocessing steps, such as registering voxels to a standardized brain atlas, which yields a significant computational overhead, hampers widespread usage and results in the predicted brain-age to be sensitive to preprocessing parameters. Here we describe a 3D Convolutional Neural Network (CNN) based on the ResNet architecture being trained on raw, non-registered T$_ 1$-weighted MRI data of N=10,691 samples from the German National Cohort and additionally applied and validated in N=2,173 samples from three independent studies using transfer learning. For comparison, state-of-the-art models using preprocessed neuroimaging data are trained and validated on the same samples. The 3D CNN using raw neuroimaging data predicts age with a mean average deviation of 2.84 years, outperforming the state-of-the-art brain-age models using preprocessed data. Since our approach is invariant to preprocessing software and parameter choices, it enables faster, more robust and more accurate brain-age modeling.

Karim Huesmann, Soeren Klemm, Lars Linsen et al.

Overfitting is one of the most common problems when training deep neural networks on comparatively small datasets. Here, we demonstrate that neural network activation sparsity is a reliable indicator for overfitting which we utilize to propose novel targeted sparsity visualization and regularization strategies. Based on these strategies we are able to understand and counteract overfitting caused by activation sparsity and filter correlation in a targeted layer-by-layer manner. Our results demonstrate that targeted sparsity regularization can efficiently be used to regularize well-known datasets and architectures with a significant increase in image classification performance while outperforming both dropout and batch normalization. Ultimately, our study reveals novel insights into the contradicting concepts of activation sparsity and network capacity by demonstrating that targeted sparsity regularization enables salient and discriminative feature learning while exploiting the full capacity of deep models without suffering from overfitting, even when trained excessively.

Ramona Leenings, Nils Ralf Winter, Lucas Plagwitz et al.

PHOTONAI is a high-level Python API designed to simplify and accelerate machine learning model development. It functions as a unifying framework allowing the user to easily access and combine algorithms from different toolboxes into custom algorithm sequences. It is especially designed to support the iterative model development process and automates the repetitive training, hyperparameter optimization and evaluation tasks. Importantly, the workflow ensures unbiased performance estimates while still allowing the user to fully customize the machine learning analysis. PHOTONAI extends existing solutions with a novel pipeline implementation supporting more complex data streams, feature combinations, and algorithm selection. Metrics and results can be conveniently visualized using the PHOTONAI Explorer and predictive models are shareable in a standardized format for further external validation or application. A growing add-on ecosystem allows researchers to offer data modality specific algorithms to the community and enhance machine learning in the areas of the life sciences. Its practical utility is demonstrated on an exemplary medical machine learning problem, achieving a state-of-the-art solution in few lines of code. Source code is publicly available on Github, while examples and documentation can be found at www.photon-ai.com.