Yuanyuan Zhang

Yingzhou Lu, Lulu Chen, Yuanyuan Zhang et al.

Machine learning heavily relies on data, but real-world applications often encounter various data-related issues. These include data of poor quality, insufficient data points leading to under-fitting of machine learning models, and difficulties in data access due to concerns surrounding privacy, safety, and regulations. In light of these challenges, the concept of synthetic data generation emerges as a promising alternative that allows for data sharing and utilization in ways that real-world data cannot facilitate. This paper presents a comprehensive systematic review of existing studies that employ machine learning models for the purpose of generating synthetic data. The review encompasses various perspectives, starting with the applications of synthetic data generation, spanning computer vision, speech, natural language processing, healthcare, and business domains. Additionally, it explores different machine learning methods, with particular emphasis on neural network architectures and deep generative models. The paper also addresses the crucial aspects of privacy and fairness concerns related to synthetic data generation. Furthermore, this study identifies the challenges and opportunities prevalent in this emerging field, shedding light on the potential avenues for future research. By delving into the intricacies of synthetic data generation, this paper aims to contribute to the advancement of knowledge and inspire further exploration in synthetic data generation.

LSST Dark Energy Science Collaboration, Eric Aubourg, Camille Avestruz et al.

The Vera C. Rubin Observatory's Legacy Survey of Space and Time (LSST) will produce unprecedented volumes of heterogeneous astronomical data (images, catalogs, and alerts) that challenge traditional analysis pipelines. The LSST Dark Energy Science Collaboration (DESC) aims to derive robust constraints on dark energy and dark matter from these data, requiring methods that are statistically powerful, scalable, and operationally reliable. Artificial intelligence and machine learning (AI/ML) are already embedded across DESC science workflows, from photometric redshifts and transient classification to weak lensing inference and cosmological simulations. Yet their utility for precision cosmology hinges on trustworthy uncertainty quantification, robustness to covariate shift and model misspecification, and reproducible integration within scientific pipelines. This white paper surveys the current landscape of AI/ML across DESC's primary cosmological probes and cross-cutting analyses, revealing that the same core methodologies and fundamental challenges recur across disparate science cases. Since progress on these cross-cutting challenges would benefit multiple probes simultaneously, we identify key methodological research priorities, including Bayesian inference at scale, physics-informed methods, validation frameworks, and active learning for discovery. With an eye on emerging techniques, we also explore the potential of the latest foundation model methodologies and LLM-driven agentic AI systems to reshape DESC workflows, provided their deployment is coupled with rigorous evaluation and governance. Finally, we discuss critical software, computing, data infrastructure, and human capital requirements for the successful deployment of these new methodologies, and consider associated risks and opportunities for broader coordination with external actors.

Wen Li, Wei Chen, Shiyue Wang et al.

High-speed railway (HSR) communications are pivotal for ensuring rail safety, operations, maintenance, and delivering passenger information services. The high speed of trains creates rapidly time-varying wireless channels, increases the signaling overhead, and reduces the system throughput, making it difficult to meet the growing and stringent needs of HSR applications. In this article, we explore artificial intelligence (AI)-based beam-level and cell-level mobility management suitable for HSR communications. Particularly, we propose a compressed spatial multi-beam measurements scheme via compressive sensing for beam-level mobility management in HSR communications. In comparison to traditional down-sampling spatial beam measurements, this method leads to improved spatial-temporal beam prediction accuracy with the same measurement overhead. Moreover, we propose a novel AI-based proactive handover scheme to predict handover events and reduce radio link failure (RLF) rates in HSR communications. Compared with the traditional event A3-based handover mechanism, the proposed approach significantly reduces the RLF rates which saves 50% beam measurement overhead.

Yuanyuan Zhang, Runwei Guan, Lingxiao Li et al.

Radar-based contactless cardiac monitoring has become a popular research direction recently, but the fine-grained electrocardiogram (ECG) signal is still hard to reconstruct from millimeter-wave radar signal. The key obstacle is to decouple the cardiac activities in the electrical domain (i.e., ECG) from that in the mechanical domain (i.e., heartbeat), and most existing research only uses pure data-driven methods to map such domain transformation as a black box. Therefore, this work first proposes a signal model for domain transformation, and then a novel deep learning framework called radarODE is designed to fuse the temporal and morphological features extracted from radar signals and generate ECG. In addition, ordinary differential equations are embedded in radarODE as a decoder to provide morphological prior, helping the convergence of the model training and improving the robustness under body movements. After being validated on the dataset, the proposed radarODE achieves better performance compared with the benchmark in terms of missed detection rate, root mean square error, Pearson correlation coefficient with the improvement of 9%, 16% and 19%, respectively. The validation results imply that radarODE is capable of recovering ECG signals from radar signals with high fidelity and can be potentially implemented in real-life scenarios.

Yidong Zhou, Jintai Chen, Jinglei Cheng et al.

Drug discovery is lengthy and expensive, with traditional computer-aided design facing limits. This paper examines integrating quantum computing across the drug development cycle to accelerate and enhance workflows and rigorous decision-making. It highlights quantum approaches for molecular simulation, drug-target interaction prediction, and optimizing clinical trials. Leveraging quantum capabilities could accelerate timelines and costs for bringing therapies to market, improving efficiency and ultimately benefiting public health.

Yuanyuan Zhang, Zhongying Chen

This paper is devoted to analyze of nonconforming finite volume methods (FVMs), whose trial spaces are chosen as the nonconforming finite element (FE) spaces, for solving the second order elliptic boundary value problems. We formulate the nonconforming FVMs as special types of Petrov-Galerkin methods and develop a general convergence theorem, which serves as a guide for the analysis of the nonconforming FVMs. As special examples, we shall present the triangulation based Crouzeix-Raviart (C-R) FVM as well as the rectangle mesh based hybrid Wilson FVM. Their optimal error estimates in the mesh dependent $H^1$-norm will be obtained under the condition that the primary mesh is regular. For the hybrid Wilson FVM, we prove that it enjoys the same optimal error order in the $L^2$-norm as that of the Wilson FEM. Numerical experiments are also presented to confirm the theoretical results.

Zhihong Lei, Xingyu Na, Mingbin Xu et al.

Large language models (LLMs) have shown superb capability of modeling multimodal signals including audio and text, allowing the model to generate spoken or textual response given a speech input. However, it remains a challenge for the model to recognize personal named entities, such as contacts in a phone book, when the input modality is speech. In this work, we start with a speech recognition task and propose a retrieval-based solution to contextualize the LLM: we first let the LLM detect named entities in speech without any context, then use this named entity as a query to retrieve phonetically similar named entities from a personal database and feed them to the LLM, and finally run context-aware LLM decoding. In a voice assistant task, our solution achieved up to 30.2% relative word error rate reduction and 73.6% relative named entity error rate reduction compared to a baseline system without contextualization. Notably, our solution by design avoids prompting the LLM with the full named entity database, making it highly efficient and applicable to large named entity databases.

Wanghan Xu, Yuhao Zhou, Yifan Zhou et al.

Despite advances in scientific AI, a coherent framework for Scientific General Intelligence (SGI)-the ability to autonomously conceive, investigate, and reason across scientific domains-remains lacking. We present an operational SGI definition grounded in the Practical Inquiry Model (PIM: Deliberation, Conception, Action, Perception) and operationalize it via four scientist-aligned tasks: deep research, idea generation, dry/wet experiments, and experimental reasoning. SGI-Bench comprises over 1,000 expert-curated, cross-disciplinary samples inspired by Science's 125 Big Questions, enabling systematic evaluation of state-of-the-art LLMs. Results reveal gaps: low exact match (10--20%) in deep research despite step-level alignment; ideas lacking feasibility and detail; high code executability but low execution result accuracy in dry experiments; low sequence fidelity in wet protocols; and persistent multimodal comparative-reasoning challenges. We further introduce Test-Time Reinforcement Learning (TTRL), which optimizes retrieval-augmented novelty rewards at inference, enhancing hypothesis novelty without reference answer. Together, our PIM-grounded definition, workflow-centric benchmark, and empirical insights establish a foundation for AI systems that genuinely participate in scientific discovery.

Zhihong Lei, Mingbin Xu, Shiyi Han et al.

Recent advances in deep learning and automatic speech recognition (ASR) have enabled the end-to-end (E2E) ASR system and boosted the accuracy to a new level. The E2E systems implicitly model all conventional ASR components, such as the acoustic model (AM) and the language model (LM), in a single network trained on audio-text pairs. Despite this simpler system architecture, fusing a separate LM, trained exclusively on text corpora, into the E2E system has proven to be beneficial. However, the application of LM fusion presents certain drawbacks, such as its inability to address the domain mismatch issue inherent to the internal AM. Drawing inspiration from the concept of LM fusion, we propose the integration of an external AM into the E2E system to better address the domain mismatch. By implementing this novel approach, we have achieved a significant reduction in the word error rate, with an impressive drop of up to 14.3% across varied test sets. We also discovered that this AM fusion approach is particularly beneficial in enhancing named entity recognition.

Shayan Nejadshamsi, Yuanyuan Zhang, Shadi Zaki et al.

Accurate and timely crop yield prediction is crucial for global food security and modern agricultural management. Traditional methods often lack the scalability and granularity required for precision farming. This paper introduces CYPRESS (Crop Yield Prediction via Regression on Prithvi's Encoder for Satellite Sensing), a deep learning model designed for high-resolution, intra-field canola yield prediction. CYPRESS leverages a pre-trained, large-scale geospatial foundation model (Prithvi-EO-2.0-600M) and adapts it for a continuous regression task, transforming multi-temporal satellite imagery into dense, pixel-level yield maps. Evaluated on a comprehensive dataset from the Canadian Prairies, CYPRESS demonstrates superior performance over existing deep learning-based yield prediction models, highlighting the effectiveness of fine-tuning foundation models for specialized agricultural applications. By providing a continuous, high-resolution output, CYPRESS offers a more actionable tool for precision agriculture than conventional classification or county-level aggregation methods. This work validates a novel approach that bridges the gap between large-scale Earth observation and on-farm decision-making, offering a scalable solution for detailed agricultural monitoring.

Yuanyuan Zhang, Rui Yang, Yutao Yue et al.

Millimeter-wave radar is promising to provide robust and accurate vital sign monitoring in an unobtrusive manner. However, the radar signal might be distorted in propagation by ambient noise or random body movement, ruining the subtle cardiac activities and destroying the vital sign recovery. In particular, the recovery of electrocardiogram (ECG) signal heavily relies on the deep-learning model and is sensitive to noise. Therefore, this work creatively deconstructs the radar-based ECG recovery into three individual tasks and proposes a multi-task learning (MTL) framework, radarODE-MTL, to increase the robustness against consistent and abrupt noises. In addition, to alleviate the potential conflicts in optimizing individual tasks, a novel multi-task optimization strategy, eccentric gradient alignment (EGA), is proposed to dynamically trim the task-specific gradients based on task difficulties in orthogonal space. The proposed radarODE-MTL with EGA is evaluated on the public dataset with prominent improvements in accuracy, and the performance remains consistent under noises. The experimental results indicate that radarODE-MTL could reconstruct accurate ECG signals robustly from radar signals and imply the application prospect in real-life situations. The code is available at: http://github.com/ZYY0844/radarODE-MTL.

Yize Jiang, Xinze Li, Yuanyuan Zhang et al.

Existing protein-ligand docking studies typically focus on the self-docking scenario, which is less practical in real applications. Moreover, some studies involve heavy frameworks requiring extensive training, posing challenges for convenient and efficient assessment of docking methods. To fill these gaps, we design PoseX, an open-source benchmark to evaluate both self-docking and cross-docking, enabling a practical and comprehensive assessment of algorithmic advances. Specifically, we curated a novel dataset comprising 718 entries for self-docking and 1,312 entries for cross-docking; second, we incorporated 23 docking methods in three methodological categories, including physics-based methods (e.g., Schrödinger Glide), AI docking methods (e.g., DiffDock) and AI co-folding methods (e.g., AlphaFold3); third, we developed a relaxation method for post-processing to minimize conformational energy and refine binding poses; fourth, we built a leaderboard to rank submitted models in real-time. We derived some key insights and conclusions from extensive experiments: (1) AI approaches have consistently outperformed physics-based methods in overall docking success rate. (2) Most intra- and intermolecular clashes of AI approaches can be greatly alleviated with relaxation, which means combining AI modeling with physics-based post-processing could achieve excellent performance. (3) AI co-folding methods exhibit ligand chirality issues, except for Boltz-1x, which introduced physics-inspired potentials to fix hallucinations, suggesting modeling on stereochemistry improves the structural plausibility markedly. (4) Specifying binding pockets significantly promotes docking performance, indicating that pocket information can be leveraged adequately, particularly for AI co-folding methods, in future modeling efforts. The code, dataset, and leaderboard are released at https://github.com/CataAI/PoseX.

Tianyi Chen, Yingzhou Lu, Nan Hao et al.

The importance of uncertainty quantification is increasingly recognized in the diverse field of machine learning. Accurately assessing model prediction uncertainty can help provide deeper understanding and confidence for researchers and practitioners. This is especially critical in medical diagnosis and drug discovery areas, where reliable predictions directly impact research quality and patient health. In this paper, we proposed incorporating uncertainty quantification into clinical trial outcome predictions. Our main goal is to enhance the model's ability to discern nuanced differences, thereby significantly improving its overall performance. We have adopted a selective classification approach to fulfill our objective, integrating it seamlessly with the Hierarchical Interaction Network (HINT), which is at the forefront of clinical trial prediction modeling. Selective classification, encompassing a spectrum of methods for uncertainty quantification, empowers the model to withhold decision-making in the face of samples marked by ambiguity or low confidence, thereby amplifying the accuracy of predictions for the instances it chooses to classify. A series of comprehensive experiments demonstrate that incorporating selective classification into clinical trial predictions markedly enhances the model's performance, as evidenced by significant upticks in pivotal metrics such as PR-AUC, F1, ROC-AUC, and overall accuracy. Specifically, the proposed method achieved 32.37\%, 21.43\%, and 13.27\% relative improvement on PR-AUC over the base model (HINT) in phase I, II, and III trial outcome prediction, respectively. When predicting phase III, our method reaches 0.9022 PR-AUC scores. These findings illustrate the robustness and prospective utility of this strategy within the area of clinical trial predictions, potentially setting a new benchmark in the field.

Ming Hu, Chenglong Ma, Wei Li et al. · pku

Scientific Large Language Models (Sci-LLMs) are transforming how knowledge is represented, integrated, and applied in scientific research, yet their progress is shaped by the complex nature of scientific data. This survey presents a comprehensive, data-centric synthesis that reframes the development of Sci-LLMs as a co-evolution between models and their underlying data substrate. We formulate a unified taxonomy of scientific data and a hierarchical model of scientific knowledge, emphasizing the multimodal, cross-scale, and domain-specific challenges that differentiate scientific corpora from general natural language processing datasets. We systematically review recent Sci-LLMs, from general-purpose foundations to specialized models across diverse scientific disciplines, alongside an extensive analysis of over 270 pre-/post-training datasets, showing why Sci-LLMs pose distinct demands -- heterogeneous, multi-scale, uncertainty-laden corpora that require representations preserving domain invariance and enabling cross-modal reasoning. On evaluation, we examine over 190 benchmark datasets and trace a shift from static exams toward process- and discovery-oriented assessments with advanced evaluation protocols. These data-centric analyses highlight persistent issues in scientific data development and discuss emerging solutions involving semi-automated annotation pipelines and expert validation. Finally, we outline a paradigm shift toward closed-loop systems where autonomous agents based on Sci-LLMs actively experiment, validate, and contribute to a living, evolving knowledge base. Collectively, this work provides a roadmap for building trustworthy, continually evolving artificial intelligence (AI) systems that function as a true partner in accelerating scientific discovery.

Xiangrui Liu, Yuanyuan Zhang, Qianyu Shang et al.

Foundation models, first introduced in 2021, refer to large-scale pretrained models (e.g., large language models (LLMs) and vision-language models (VLMs)) that learn from extensive unlabeled datasets through unsupervised methods, enabling them to excel in diverse downstream tasks. These models, like GPT, can be adapted to various applications such as question answering and visual understanding, outperforming task-specific AI models and earning their name due to broad applicability across fields. The development of biomedical foundation models marks a significant milestone in the use of artificial intelligence (AI) to understand complex biological phenomena and advance medical research and practice. This survey explores the potential of foundation models in diverse domains within biomedical fields, including computational biology, drug discovery and development, clinical informatics, medical imaging, and public health. The purpose of this survey is to inspire ongoing research in the application of foundation models to health science.

Zerui Xu, Fang Wu, Yuanyuan Zhang et al.

Machine learning (ML) exhibits promise in the clinical domain. However, it is constrained by data scarcity and ethical considerations, as the generation of clinical trials presents significant challenges due to stringent privacy regulations, high costs, and the extended duration required for conducting studies with human participants. Despite the advancements of large language models (LLMs) in general generation tasks, their potential in facilitating the generation of synthetic clinical trials is under-explored. To address this gap, we introduce a novel Retrieval-Reasoning few-shot framework that leverages LLMs to generate artificial yet realistic and diverse clinical trials with binary success/failure labels. Experiments conducted on real clinical trials from the \url{ClinicalTrials.gov} database demonstrate that our synthetic data can effectively augment real datasets. Furthermore, by fine-tuning a pre-trained model as a binary classifier on synthetic clinical trial datasets, we demonstrate that this augmentation enhances model training for downstream tasks such as trial outcome prediction. Our findings suggest that LLMs for synthetic clinical trial generation hold promise for accelerating clinical research and upholding ethical standards for patient privacy. The code is publicly available at https://anonymous.4open.science/r/Retrieval_Reasoning_Clinical_Trial_Generation-3EC4.

Yuanyuan Zhang, Sijie Xiong, Rui Yang et al.

Radar-based wellness monitoring is becoming an effective measurement to provide accurate vital signs in a contactless manner, but data scarcity retards the related research on deep-learning-based methods. Data augmentation is commonly used to enrich the dataset by modifying the existing data, but most augmentation techniques can only couple with classification tasks. To enable the augmentation for regression tasks, this research proposes a spectrogram augmentation method, Horcrux, for radar-based cardiac feature monitoring (e.g., heartbeat detection, electrocardiogram reconstruction) with both classification and regression tasks involved. The proposed method is designed to increase the diversity of input samples while the augmented spectrogram is still faithful to the original ground truth vital sign. In addition, Horcrux proposes to inject zero values in specific areas to enhance the awareness of the deep learning model on subtle cardiac features, improving the performance for the limited dataset. Experimental result shows that Horcrux achieves an overall improvement of 16.20% in cardiac monitoring and has the potential to be extended to other spectrogram-based tasks. The code will be released upon publication.

Yajun Yu, Guoping Xu, Steve Jiang et al.

To develop an integrated transcriptome-proteome framework for identifying concurrent biomarkers predictive of radiation response, as measured by survival fraction at 2 Gy (SF2), in non-small cell lung cancer (NSCLC) cell lines. RNA sequencing (RNA-seq) and data-independent acquisition mass spectrometry (DIA-MS) proteomic data were collected from 73 and 46 NSCLC cell lines, respectively. Following preprocessing, 1,605 shared genes were retained for analysis. Feature selection was performed using least absolute shrinkage and selection operator (Lasso) regression with a frequency-based ranking criterion under five-fold cross-validation repeated ten times. Support vector regression (SVR) models were constructed using transcriptome-only, proteome-only, and combined transcriptome-proteome feature sets. Model performance was assessed by the coefficient of determination (R2) and root mean square error (RMSE). Correlation analyses evaluated concordance between RNA and protein expression and the relationships of selected biomarkers with SF2. RNA-protein expression exhibited significant positive correlations (median Pearson's r = 0.363). Independent pipelines identified 20 prioritized gene signatures from transcriptomic, proteomic, and combined datasets. Models trained on single-omic features achieved limited cross-omic generalizability, while the combined model demonstrated balanced predictive accuracy in both datasets (R2=0.461, RMSE=0.120 for transcriptome; R2=0.604, RMSE=0.111 for proteome). This study presents the first proteotranscriptomic framework for SF2 prediction in NSCLC, highlighting the complementary value of integrating transcriptomic and proteomic data. The identified concurrent biomarkers capture both transcriptional regulation and functional protein activity, offering mechanistic insights and translational potential.

Yunxuan Jiang, Silan Hu, Xiaoning Wang et al.

Large language models (LLMs) become increasingly integrated into data science workflows for automated system design. However, these LLM-driven data science systems rely solely on the internal reasoning of LLMs, lacking guidance from scientific and theoretical principles. This limits their trustworthiness and robustness, especially when dealing with noisy and complex real-world datasets. This paper provides VDSAgents, a multi-agent system grounded in the Predictability-Computability-Stability (PCS) principles proposed in the Veridical Data Science (VDS) framework. Guided by PCS principles, the system implements a modular workflow for data cleaning, feature engineering, modeling, and evaluation. Each phase is handled by an elegant agent, incorporating perturbation analysis, unit testing, and model validation to ensure both functionality and scientific auditability. We evaluate VDSAgents on nine datasets with diverse characteristics, comparing it with state-of-the-art end-to-end data science systems, such as AutoKaggle and DataInterpreter, using DeepSeek-V3 and GPT-4o as backends. VDSAgents consistently outperforms the results of AutoKaggle and DataInterpreter, which validates the feasibility of embedding PCS principles into LLM-driven data science automation.

Hao Peng, Yuanyuan Zhang, Steve Jiang et al.

Radiation response in cancer is shaped by complex, patient specific biology, yet current treatment strategies often rely on uniform dose prescriptions without accounting for tumor heterogeneity. In this study, we introduce a meta learning framework for one-shot prediction of radiosensitivity measured by SF2 using cell line level gene expression data. Unlike the widely used Radiosensitivity Index RSI a rank-based linear model trained on a fixed 10-gene signature, our proposed meta-learned model allows the importance of each gene to vary by sample through fine tuning. This flexibility addresses key limitations of static models like RSI, which assume uniform gene contributions across tumor types and discard expression magnitude and gene gene interactions. Our results show that meta learning offers robust generalization to unseen samples and performs well in tumor subgroups with high radiosensitivity variability, such as adenocarcinoma and large cell carcinoma. By learning transferable structure across tasks while preserving sample specific adaptability, our approach enables rapid adaptation to individual samples, improving predictive accuracy across diverse tumor subtypes while uncovering context dependent patterns of gene influence that may inform personalized therapy.

Yuanyuan Zhang, Haocheng Zhao, Sijie Xiong et al.

Electrocardiogram (ECG), as a crucial find-grained cardiac feature, has been successfully recovered from radar signals in the literature, but the performance heavily relies on the high-quality radar signal and numerous radar-ECG pairs for training, restricting the applications in new scenarios due to data scarcity. Therefore, this work will focus on radar-based ECG recovery in new scenarios with limited data and propose a cardio-focusing and -tracking (CFT) algorithm to precisely track the cardiac location to ensure an efficient acquisition of high-quality radar signals. Furthermore, a transfer learning model (RFcardi) is proposed to extract cardio-related information from the radar signal without ECG ground truth based on the intrinsic sparsity of cardiac features, and only a few synchronous radar-ECG pairs are required to fine-tune the pre-trained model for the ECG recovery. The experimental results reveal that the proposed CFT can dynamically identify the cardiac location, and the RFcardi model can effectively generate faithful ECG recoveries after using a small number of radar-ECG pairs for training. The code and dataset are available after the publication.

Yuanyuan Zhang, Zhengjun Yue, Tanvina Patel et al.

State-of-the-art ASRs show suboptimal performance for child speech. The scarcity of child speech limits the development of child speech recognition (CSR). Therefore, we studied child-to-child voice conversion (VC) from existing child speakers in the dataset and additional (new) child speakers via monolingual and cross-lingual (Dutch-to-German) VC, respectively. The results showed that cross-lingual child-to-child VC significantly improved child ASR performance. Experiments on the impact of the quantity of child-to-child cross-lingual VC-generated data on fine-tuning (FT) ASR models gave the best results with two-fold augmentation for our FT-Conformer model and FT-Whisper model which reduced WERs with ~3% absolute compared to the baseline, and with six-fold augmentation for the model trained from scratch, which improved by an absolute 3.6% WER. Moreover, using a small amount of "high-quality" VC-generated data achieved similar results to those of our best-FT models.

Jan Silovsky, Liuhui Deng, Arturo Argueta et al.

Voice technology has become ubiquitous recently. However, the accuracy, and hence experience, in different languages varies significantly, which makes the technology not equally inclusive. The availability of data for different languages is one of the key factors affecting accuracy, especially in training of all-neural end-to-end automatic speech recognition systems. Cross-lingual knowledge transfer and iterative pseudo-labeling are two techniques that have been shown to be successful for improving the accuracy of ASR systems, in particular for low-resource languages, like Ukrainian. Our goal is to train an all-neural Transducer-based ASR system to replace a DNN-HMM hybrid system with no manually annotated training data. We show that the Transducer system trained using transcripts produced by the hybrid system achieves 18% reduction in terms of word error rate. However, using a combination of cross-lingual knowledge transfer from related languages and iterative pseudo-labeling, we are able to achieve 35% reduction of the error rate.

Hengshun Zhou, Jun Du, Yuanyuan Zhang et al.

Multimodal emotion recognition is a challenging task in emotion computing as it is quite difficult to extract discriminative features to identify the subtle differences in human emotions with abstract concept and multiple expressions. Moreover, how to fully utilize both audio and visual information is still an open problem. In this paper, we propose a novel multimodal fusion attention network for audio-visual emotion recognition based on adaptive and multi-level factorized bilinear pooling (FBP). First, for the audio stream, a fully convolutional network (FCN) equipped with 1-D attention mechanism and local response normalization is designed for speech emotion recognition. Next, a global FBP (G-FBP) approach is presented to perform audio-visual information fusion by integrating selfattention based video stream with the proposed audio stream. To improve G-FBP, an adaptive strategy (AG-FBP) to dynamically calculate the fusion weight of two modalities is devised based on the emotion-related representation vectors from the attention mechanism of respective modalities. Finally, to fully utilize the local emotion information, adaptive and multi-level FBP (AMFBP) is introduced by combining both global-trunk and intratrunk data in one recording on top of AG-FBP. Tested on the IEMOCAP corpus for speech emotion recognition with only audio stream, the new FCN method outperforms the state-ofthe-art results with an accuracy of 71.40%. Moreover, validated on the AFEW database of EmotiW2019 sub-challenge and the IEMOCAP corpus for audio-visual emotion recognition, the proposed AM-FBP approach achieves the best accuracy of 63.09% and 75.49% respectively on the test set.

Hengshun Zhou, Debin Meng, Yuanyuan Zhang et al.

The audio-video based emotion recognition aims to classify a given video into basic emotions. In this paper, we describe our approaches in EmotiW 2019, which mainly explores emotion features and feature fusion strategies for audio and visual modality. For emotion features, we explore audio feature with both speech-spectrogram and Log Mel-spectrogram and evaluate several facial features with different CNN models and different emotion pretrained strategies. For fusion strategies, we explore intra-modal and cross-modal fusion methods, such as designing attention mechanisms to highlights important emotion feature, exploring feature concatenation and factorized bilinear pooling (FBP) for cross-modal feature fusion. With careful evaluation, we obtain 65.5% on the AFEW validation set and 62.48% on the test set and rank third in the challenge.

Xinwei Li, Yuanyuan Zhang, Xiaodan Zhuang et al.

Inspired by SpecAugment -- a data augmentation method for end-to-end ASR systems, we propose a frame-level SpecAugment method (f-SpecAugment) to improve the performance of deep convolutional neural networks (CNN) for hybrid HMM based ASR systems. Similar to the utterance level SpecAugment, f-SpecAugment performs three transformations: time warping, frequency masking, and time masking. Instead of applying the transformations at the utterance level, f-SpecAugment applies them to each convolution window independently during training. We demonstrate that f-SpecAugment is more effective than the utterance level SpecAugment for deep CNN based hybrid models. We evaluate the proposed f-SpecAugment on 50-layer Self-Normalizing Deep CNN (SNDCNN) acoustic models trained with up to 25000 hours of training data. We observe f-SpecAugment reduces WER by 0.5-4.5% relatively across different ASR tasks for four languages. As the benefits of augmentation techniques tend to diminish as training data size increases, the large scale training reported is important in understanding the effectiveness of f-SpecAugment. Our experiments demonstrate that even with 25k training data, f-SpecAugment is still effective. We also demonstrate that f-SpecAugment has benefits approximately equivalent to doubling the amount of training data for deep CNNs.

Gongbo Liang, Yuanyuan Su, Sheng-Chieh Lin et al.

Most galaxies in the nearby Universe are gravitationally bound to a cluster or group of galaxies. Their optical contents, such as optical richness, are crucial for understanding the co-evolution of galaxies and large-scale structures in modern astronomy and cosmology. The determination of optical richness can be challenging. We propose a self-supervised approach for estimating optical richness from multi-band optical images. The method uses the data properties of the multi-band optical images for pre-training, which enables learning feature representations from a large but unlabeled dataset. We apply the proposed method to the Sloan Digital Sky Survey. The result shows our estimate of optical richness lowers the mean absolute error and intrinsic scatter by 11.84% and 20.78%, respectively, while reducing the need for labeled training data by up to 60%. We believe the proposed method will benefit astronomy and cosmology, where a large number of unlabeled multi-band images are available, but acquiring image labels is costly.

Yikun Hu, Hui Wang, Yuanyuan Zhang et al.

Binary code similarity comparison is a methodology for identifying similar or identical code fragments in binary programs. It is indispensable in fields of software engineering and security, which has many important applications (e.g., plagiarism detection, bug detection). With the widespread of smart and IoT (Internet of Things) devices, an increasing number of programs are ported to multiple architectures (e.g. ARM, MIPS). It becomes necessary to detect similar binary code across architectures as well. The main challenge of this topic lies in the semantics-equivalent code transformation resulting from different compilation settings, code obfuscation, and varied instruction set architectures. Another challenge is the trade-off between comparison accuracy and coverage. Unfortunately, existing methods still heavily rely on semantics-less code features which are susceptible to the code transformation. Additionally, they perform the comparison merely either in a static or in a dynamic manner, which cannot achieve high accuracy and coverage simultaneously. In this paper, we propose a semantics-based hybrid method to compare binary function similarity. We execute the reference function with test cases, then emulate the execution of every target function with the runtime information migrated from the reference function. Semantic signatures are extracted during the execution as well as the emulation. Lastly, similarity scores are calculated from the signatures to measure the likeness of functions. We have implemented the method in a prototype system designated as BinMatch and evaluate it with nine real-word projects compiled with different compilation settings, on variant architectures, and with commonly-used obfuscation methods, totally performing over 100 million pairs of function comparison.

Yuanyuan Zhang, Zi-Rui Wang, Jun Du

Automatic emotion recognition (AER) is a challenging task due to the abstract concept and multiple expressions of emotion. Although there is no consensus on a definition, human emotional states usually can be apperceived by auditory and visual systems. Inspired by this cognitive process in human beings, it's natural to simultaneously utilize audio and visual information in AER. However, most traditional fusion approaches only build a linear paradigm, such as feature concatenation and multi-system fusion, which hardly captures complex association between audio and video. In this paper, we introduce factorized bilinear pooling (FBP) to deeply integrate the features of audio and video. Specifically, the features are selected through the embedded attention mechanism from respective modalities to obtain the emotion-related regions. The whole pipeline can be completed in a neural network. Validated on the AFEW database of the audio-video sub-challenge in EmotiW2018, the proposed approach achieves an accuracy of 62.48%, outperforming the state-of-the-art result.

Zhenghang Zhong, Zhe Tang, Xiangxing Li et al.

In this paper, we present a new location fingerprinting database comprised of Wi-Fi received signal strength (RSS) and geomagnetic field intensity measured with multiple devices at a multi-floor building in Xi'an Jiatong-Liverpool University, Suzhou, China. We also provide preliminary results of localization and trajectory estimation based on convolutional neural network (CNN) and long short-term memory (LSTM) network with this database. For localization, we map RSS data for a reference point to an image-like, two-dimensional array and then apply CNN which is popular in image and video analysis and recognition. For trajectory estimation, we use a modified random way point model to efficiently generate continuous step traces imitating human walking and train a stacked two-layer LSTM network with the generated data to remember the changing pattern of geomagnetic field intensity against (x,y) coordinates. Experimental results demonstrate the usefulness of our new database and the feasibility of the CNN and LSTM-based localization and trajectory estimation with the database.

Yikun Hu, Yuanyuan Zhang, Juanru Li et al.

Binary code clone analysis is an important technique which has a wide range of applications in software engineering (e.g., plagiarism detection, bug detection). The main challenge of the topic lies in the semantics-equivalent code transformation (e.g., optimization, obfuscation) which would alter representations of binary code tremendously. Another chal- lenge is the trade-off between detection accuracy and coverage. Unfortunately, existing techniques still rely on semantics-less code features which are susceptible to the code transformation. Besides, they adopt merely either a static or a dynamic approach to detect binary code clones, which cannot achieve high accuracy and coverage simultaneously. In this paper, we propose a semantics-based hybrid approach to detect binary clone functions. We execute a template binary function with its test cases, and emulate the execution of every target function for clone comparison with the runtime information migrated from that template function. The semantic signatures are extracted during the execution of the template function and emulation of the target function. Lastly, a similarity score is calculated from their signatures to measure their likeness. We implement the approach in a prototype system designated as BinMatch which analyzes IA-32 binary code on the Linux platform. We evaluate BinMatch with eight real-world projects compiled with different compilation configurations and commonly-used obfuscation methods, totally performing over 100 million pairs of function comparison. The experimental results show that BinMatch is robust to the semantics-equivalent code transformation. Besides, it not only covers all target functions for clone analysis, but also improves the detection accuracy comparing to the state-of-the-art solutions.

Yuanyuan Zhang, Jun Du, Zirui Wang et al.

Speech emotion recognition is a challenging task for three main reasons: 1) human emotion is abstract, which means it is hard to distinguish; 2) in general, human emotion can only be detected in some specific moments during a long utterance; 3) speech data with emotional labeling is usually limited. In this paper, we present a novel attention based fully convolutional network for speech emotion recognition. We employ fully convolutional network as it is able to handle variable-length speech, free of the demand of segmentation to keep critical information not lost. The proposed attention mechanism can make our model be aware of which time-frequency region of speech spectrogram is more emotion-relevant. Considering limited data, the transfer learning is also adapted to improve the accuracy. Especially, it's interesting to observe obvious improvement obtained with natural scene image based pre-trained model. Validated on the publicly available IEMOCAP corpus, the proposed model outperformed the state-of-the-art methods with a weighted accuracy of 70.4% and an unweighted accuracy of 63.9% respectively.

James Z. Wang, Yuanyuan Zhang, Liang Dong et al.

Currently, most people use PubMed to search the MEDLINE database, an important bibliographical information source for life science and biomedical information. However, PubMed has some drawbacks that make it difficult to find relevant publications pertaining to users' individual intentions, especially for non-expert users. To ameliorate the disadvantages of PubMed, we developed G-Bean, a graph based biomedical search engine, to search biomedical articles in MEDLINE database more efficiently.G-Bean addresses PubMed's limitations with three innovations: parallel document index creation,ontology-graph based query expansion, and retrieval and re-ranking of documents based on user's search intention.Performance evaluation with 106 OHSUMED benchmark queries shows that G-Bean returns more relevant results than PubMed does when using these queries to search the MEDLINE database. PubMed could not even return any search result for some OHSUMED queries because it failed to form the appropriate Boolean query statement automatically from the natural language query strings. G-Bean is available at http://bioinformatics.clemson.edu/G-Bean/index.php.G-Bean addresses PubMed's limitations with ontology-graph based query expansion, automatic document indexing, and user search intention discovery. It shows significant advantages in finding relevant articles from the MEDLINE database to meet the information need of the user.