Qiang Guan

Yuqi Zhang, Bo Fang, Yuxin Yang et al.

Predicting the structure of short peptides in protein binding pockets remains difficult because this regime requires physics-based conformational search, yet existing methods do not provide a practical way to carry out that search on current hardware. We present QSAD, a quantum-classical framework that reformulates peptide structure prediction as amino-acid-level Hamiltonian sampling and replaces iterative optimization with non-iterative Hamiltonian evolution. Executed entirely on IBM Heron R2 across 101 binding-pocket peptides (5-18 residues), QSAD improves prediction accuracy by 27-71% over all evaluated AI and quantum baselines while maintaining the lowest variance across tested lengths. QSAD also tolerates noise levels 3-5x beyond typical hardware error rates, where iterative methods fail, and reduces mean quantum execution time by 27x relative to VQE. The sampled ensemble further supports approximate reconstruction of protein energy landscapes. These results establish coarse-grained quantum sampling as a practical computational path for structure prediction in regimes where data-driven methods lack sufficient signal.

Feng He, Zhenting Wang, Qifan Wang et al.

Hallucinations in vision language models (VLMs) are commonly treated as semantic errors, yet they often arise from partial or ambiguous visual evidence. Prior work mainly focuses on detecting or suppressing hallucinations at generation time, leaving the subsequent reasoning stage largely unexplored. In this work, we study Post Hallucination Reasoning (PHR), the stage in which hallucinated semantics enter the model's inference context and influence downstream predictions. To systematically investigate PHR, we introduce HIVE, Hallucination Inference and Verification Engine, an evaluation infrastructure that enables controlled comparisons between faithful and hallucinated captions. Across nine tasks and nine models, we observe structured modality dependent patterns: hallucinated captions often improve accuracy on vision language tasks, while text only tasks exhibit limited or unstable effects. Further analyses show that hallucinated cues broaden semantic coverage and reshape reasoning dynamics while preserving stable inference. These findings highlight that hallucinated semantics may influence downstream reasoning once they enter the model's inference context. Understanding this post hallucination stage is important for improving the reliability and interpretability of multimodal reasoning systems. Code is publicly available at https://github.com/hefengcs/HIVE.