Mingwei Zhou

Zhengjie Zhang, Xiaoxie Mao, Qihao Guo et al.

Background: Alzheimer's disease (AD) diagnosis heavily relies on amyloid-beta positron emission tomography (Abeta-PET), which is limited by high cost and limited accessibility. This study explores whether Abeta-PET spatial patterns can be predicted from blood-based biomarkers (BBMs) and MRI scans. Methods: We collected Abeta-PET images, T1-weighted MRI scans, and BBMs from 566 participants. A language-enhanced generative model, driven by a large language model (LLM) and multimodal information fusion, was developed to synthesize PET images. Synthesized images were evaluated for image quality, diagnostic consistency, and clinical applicability within a fully automated diagnostic pipeline. Findings: The synthetic PET images closely resemble real PET scans in both structural details (SSIM = 0.920 +/- 0.003) and regional patterns (Pearson's r = 0.955 +/- 0.007). Diagnostic outcomes using synthetic PET show high agreement with real PET-based diagnoses (accuracy = 0.80). Using synthetic PET, we developed a fully automatic AD diagnostic pipeline integrating PET synthesis and classification. The synthetic PET-based model (AUC = 0.78) outperforms T1-based (AUC = 0.68) and BBM-based (AUC = 0.73) models, while combining synthetic PET and BBMs further improved performance (AUC = 0.79). Ablation analysis supports the advantages of LLM integration and prompt engineering. Interpretation: Our language-enhanced generative model synthesizes realistic PET images, enhancing the utility of MRI and BBMs for Abeta spatial pattern assessment and improving the diagnostic workflow for Alzheimer's disease.

Yaobin Xu, Weitang Liu, Zhongyi Jiang et al.

Traffic forecasting is a core element of intelligent traffic monitoring system. Approaches based on graph neural networks have been widely used in this task to effectively capture spatial and temporal dependencies of road networks. However, these approaches can not effectively define the complicated network topology. Besides, their cascade network structures have limitations in transmitting distinct features in the time and space dimensions. In this paper, we propose a Multi-adaptive Spatiotemporal-flow Graph Neural Network (MAF-GNN) for traffic speed forecasting. MAF-GNN introduces an effective Multi-adaptive Adjacency Matrices Mechanism to capture multiple latent spatial dependencies between traffic nodes. Additionally, we propose Spatiotemporal-flow Modules aiming to further enhance feature propagation in both time and space dimensions. MAF-GNN achieves better performance than other models on two real-world datasets of public traffic network, METR-LA and PeMS-Bay, demonstrating the effectiveness of the proposed approach.