Jing Liu

Liuyun Jiang, Yanchao Zhang, Jinyue Guo et al.

Establishing large-scale, high-resolution neural connectivity maps is fundamental to elucidating the structural basis of brain function. However, when processing terabyte- or petabyte-scale electron microscopy data, over-segmentation inherent in automated reconstruction algorithms remains a critical bottleneck, requiring extensive manual proofreading spanning person-years. To alleviate the heavy reliance on annotated data and the limited flexibility of conventional tracing methods, we propose a training-free, targeted neuron tracing framework. Specifically, we introduce a skeleton-guided Heuristic Spatial Search paradigm that leverages geometric priors to iteratively reconstruct neuronal morphologies through a probing-verification cycle. To achieve robust zero-shot semantic verification, we further develop a Dimension-Aware Semantic Verification strategy built upon the foundation model NeuroSAM 2. This strategy resolves intra-slice splits via Planar Ensemble Consensus and inter-slice splits via Axial Spatio-Temporal Propagation. Notably, we integrate the proposed workflow into the Neuroglancer visualization platform, enabling an interactive human-in-the-loop proofreading system. Experimental results demonstrate that the proposed method outperforms supervised baselines and reduces manual proofreading time by 33.4%. The source code is publicly available at https://github.com/HeadLiuYun/Probe-EM.

Handong Li, Longteng Guo, Zikang Liu et al.

Video reasoning requires models to identify and verify temporally localized evidence within long video sequences. Recent Video Large Language Models (Video-LLMs) have shown promising reasoning abilities when aligned with reinforcement learning, yet existing approaches typically rely on outcome-based rewards that supervise only the final prediction. Such supervision provides limited guidance on how models should discover the relevant temporal evidence during intermediate reasoning. In this work, we propose TimeThink, a reinforcement learning framework that explicitly guides temporal evidence discovery in Video-LLMs. Our key idea is to treat temporal clue steps as the fundamental optimization primitive of video reasoning, where each reasoning step references a candidate time interval in the video. We introduce a step-wise temporal process reward that provides localized credit assignment for these clues and a joint process--outcome optimization objective that balances reasoning fidelity with task correctness. To enable scalable training, we construct TimeThink-RFT-20K, a dataset with automatically derived temporal evidence segments. Extensive experiments across video reasoning, temporal grounding, and general video understanding benchmarks show that TimeThink consistently improves both temporal localization and reasoning performance, achieving state-of-the-art results among open-source video RL models.