This paper introduces CompressedMediQ, a novel hybrid quantum-classical machine learning pipeline specifically developed to address the computational challenges associated with high-dimensional multi-class neuroimaging data analysis. Standard neuroimaging datasets, such as large-scale MRI data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and Neuroimaging in Frontotemporal Dementia (NIFD), present significant hurdles due to their vast size and complexity. CompressedMediQ integrates classical high-performance computing (HPC) nodes for advanced MRI pre-processing and Convolutional Neural Network (CNN)-PCA-based feature extraction and reduction, addressing the limited-qubit availability for quantum data encoding in the NISQ (Noisy Intermediate-Scale Quantum) era. This is followed by Quantum Support Vector Machine (QSVM) classification. By utilizing quantum kernel methods, the pipeline optimizes feature mapping and classification, enhancing data separability and outperforming traditional neuroimaging analysis techniques. Experimental results highlight the pipeline's superior accuracy in dementia staging, validating the practical use of quantum machine learning in clinical diagnostics. Despite the limitations of NISQ devices, this proof-of-concept demonstrates the transformative potential of quantum-enhanced learning, paving the way for scalable and precise diagnostic tools in healthcare and signal processing.
Kuan-Cheng Chen, Xiaotian Xu, Henry Makhanov et al.
In this study, we introduce an innovative Quantum-enhanced Support Vector Machine (QSVM) approach for stellar classification, leveraging the power of quantum computing and GPU acceleration. Our QSVM algorithm significantly surpasses traditional methods such as K-Nearest Neighbors (KNN) and Logistic Regression (LR), particularly in handling complex binary and multi-class scenarios within the Harvard stellar classification system. The integration of quantum principles notably enhances classification accuracy, while GPU acceleration using the cuQuantum SDK ensures computational efficiency and scalability for large datasets in quantum simulators. This synergy not only accelerates the processing process but also improves the accuracy of classifying diverse stellar types, setting a new benchmark in astronomical data analysis. Our findings underscore the transformative potential of quantum machine learning in astronomical research, marking a significant leap forward in both precision and processing speed for stellar classification. This advancement has broader implications for astrophysical and related scientific fields
Kuan-Cheng Chen, Samuel Yen-Chi Chen, Chen-Yu Liu et al.
In this paper, we introduce Quantum-Train-Based Distributed Multi-Agent Reinforcement Learning (Dist-QTRL), a novel approach to addressing the scalability challenges of traditional Reinforcement Learning (RL) by integrating quantum computing principles. Quantum-Train Reinforcement Learning (QTRL) leverages parameterized quantum circuits to efficiently generate neural network parameters, achieving a \(poly(\log(N))\) reduction in the dimensionality of trainable parameters while harnessing quantum entanglement for superior data representation. The framework is designed for distributed multi-agent environments, where multiple agents, modeled as Quantum Processing Units (QPUs), operate in parallel, enabling faster convergence and enhanced scalability. Additionally, the Dist-QTRL framework can be extended to high-performance computing (HPC) environments by utilizing distributed quantum training for parameter reduction in classical neural networks, followed by inference using classical CPUs or GPUs. This hybrid quantum-HPC approach allows for further optimization in real-world applications. In this paper, we provide a mathematical formulation of the Dist-QTRL framework and explore its convergence properties, supported by empirical results demonstrating performance improvements over centric QTRL models. The results highlight the potential of quantum-enhanced RL in tackling complex, high-dimensional tasks, particularly in distributed computing settings, where our framework achieves significant speedups through parallelization without compromising model accuracy. This work paves the way for scalable, quantum-enhanced RL systems in practical applications, leveraging both quantum and classical computational resources.
Achieving high-performance computation on quantum systems presents a formidable challenge that necessitates bridging the capabilities between quantum hardware and classical computing resources. This study introduces an innovative distribution-aware Quantum-Classical-Quantum (QCQ) architecture, which integrates cutting-edge quantum software framework works with high-performance classical computing resources to address challenges in quantum simulation for materials and condensed matter physics. At the heart of this architecture is the seamless integration of VQE algorithms running on QPUs for efficient quantum state preparation, Tensor Network states, and QCNNs for classifying quantum states on classical hardware. For benchmarking quantum simulators, the QCQ architecture utilizes the cuQuantum SDK to leverage multi-GPU acceleration, integrated with PennyLane's Lightning plugin, demonstrating up to tenfold increases in computational speed for complex phase transition classification tasks compared to traditional CPU-based methods. This significant acceleration enables models such as the transverse field Ising and XXZ systems to accurately predict phase transitions with a 99.5% accuracy. The architecture's ability to distribute computation between QPUs and classical resources addresses critical bottlenecks in Quantum-HPC, paving the way for scalable quantum simulation. The QCQ framework embodies a synergistic combination of quantum algorithms, machine learning, and Quantum-HPC capabilities, enhancing its potential to provide transformative insights into the behavior of quantum systems across different scales. As quantum hardware continues to improve, this hybrid distribution-aware framework will play a crucial role in realizing the full potential of quantum computing by seamlessly integrating distributed quantum resources with the state-of-the-art classical computing infrastructure.
Samuel Yen-Chi Chen, Chen-Yu Liu, Kuan-Cheng Chen et al.
The rapid advancements in quantum computing (QC) and machine learning (ML) have led to the emergence of quantum machine learning (QML), which integrates the strengths of both fields. Among QML approaches, variational quantum circuits (VQCs), also known as quantum neural networks (QNNs), have shown promise both empirically and theoretically. However, their broader adoption is hindered by reliance on quantum hardware during inference. Hardware imperfections and limited access to quantum devices pose practical challenges. To address this, the Quantum-Train (QT) framework leverages the exponential scaling of quantum amplitudes to generate classical neural network parameters, enabling inference without quantum hardware and achieving significant parameter compression. Yet, designing effective quantum circuit architectures for such quantum-enhanced neural programmers remains non-trivial and often requires expertise in quantum information science. In this paper, we propose an automated solution using differentiable optimization. Our method jointly optimizes both conventional circuit parameters and architectural parameters in an end-to-end manner via automatic differentiation. We evaluate the proposed framework on classification, time-series prediction, and reinforcement learning tasks. Simulation results show that our method matches or outperforms manually designed QNN architectures. This work offers a scalable and automated pathway for designing QNNs that can generate classical neural network parameters across diverse applications.
Chen-Yu Liu, Kuan-Cheng Chen, Yi-Chien Chen et al.
Typhoon trajectory forecasting is essential for disaster preparedness but remains computationally demanding due to the complexity of atmospheric dynamics and the resource requirements of deep learning models. Quantum-Train (QT), a hybrid quantum-classical framework that leverages quantum neural networks (QNNs) to generate trainable parameters exclusively during training, eliminating the need for quantum hardware at inference time. Building on QT's success across multiple domains, including image classification, reinforcement learning, flood prediction, and large language model (LLM) fine-tuning, we introduce Quantum Parameter Adaptation (QPA) for efficient typhoon forecasting model learning. Integrated with an Attention-based Multi-ConvGRU model, QPA enables parameter-efficient training while maintaining predictive accuracy. This work represents the first application of quantum machine learning (QML) to large-scale typhoon trajectory prediction, offering a scalable and energy-efficient approach to climate modeling. Our results demonstrate that QPA significantly reduces the number of trainable parameters while preserving performance, making high-performance forecasting more accessible and sustainable through hybrid quantum-classical learning.
Kuan-Cheng Chen, Samuel Yen-Chi Chen, Tai-Yue Li et al.
Intrusion detection in unmanned-aerial-vehicle (UAV) swarms is complicated by high mobility, non-stationary traffic, and severe class imbalance. Leveraging a 120 k-flow simulation corpus that covers five attack types, we benchmark three quantum-machine-learning (QML) approaches - quantum kernels, variational quantum neural networks (QNNs), and hybrid quantum-trained neural networks (QT-NNs) - against strong classical baselines. All models consume an 8-feature flow representation and are evaluated under identical preprocessing, balancing, and noise-model assumptions. We analyse the influence of encoding strategy, circuit depth, qubit count, and shot noise, reporting accuracy, macro-F1, ROC-AUC, Matthews correlation, and quantum-resource footprints. Results reveal clear trade-offs: quantum kernels and QT-NNs excel in low-data, nonlinear regimes, while deeper QNNs suffer from trainability issues, and CNNs dominate when abundant data offset their larger parameter count. The complete codebase and dataset partitions are publicly released to enable reproducible QML research in network security.
Kuan-Cheng Chen, Huan-Hsin Tseng, Samuel Yen-Chi Chen et al.
We propose SUN-VQC, a variational-circuit architecture whose elementary layers are single exponentials of a symmetry-restricted Lie subgroup, $\mathrm{SU}(2^{k}) \subset \mathrm{SU}(2^{n})$ with $k \ll n$. Confining the evolution to this compact subspace reduces the dynamical Lie-algebra dimension from $\mathcal{O}(4^{n})$ to $\mathcal{O}(4^{k})$, ensuring only polynomial suppression of gradient variance and circumventing barren plateaus that plague hardware-efficient ansätze. Exact, hardware-compatible gradients are obtained using a generalized parameter-shift rule, avoiding ancillary qubits and finite-difference bias. Numerical experiments on quantum auto-encoding and classification show that SUN-VQCs sustain order-of-magnitude larger gradient signals, converge 2--3$\times$ faster, and reach higher final fidelities than depth-matched Pauli-rotation or hardware-efficient circuits. These results demonstrate that Lie-subalgebra engineering provides a principled, scalable route to barren-plateau-resilient VQAs compatible with near-term quantum processors.