Zhenyu Tang

Yankai Jiang, Weiting Tang, Haoran Sun et al.

Autonomous wet-lab experimentation requires more than plausible protocol text: biological intent, quantitative procedures, device constraints and experimental feedback must remain aligned from protocol and SOP design to code and physical execution. We developed ProtoPilot, a self-evolving multi-agent system, together with an expert-grounded benchmark and evaluation framework for testing this conversion as an experimental automation problem. The framework spans 294 synthetic-biology and molecular-biology tasks derived from 98 gold-standard protocols, wet-lab expert rubrics, device-level validity gates and real experimental tests. ProtoPilot incorporates layer-wise verifiability, multi-agent orchestration and a runtime-updated skill library to generate protocols, expand SOPs, synthesize SDK-compliant code and revise workflows from wet-lab feedback. It achieved a Top@3 expert-preference rate of 90.2%, an overall protocol-to-code gate pass rate of 89.5% and an Opentrons pass rate of 88.24%, compared with 32.35% for OpenTrons-AI. Wet-lab validation produced interpretable readouts, Sanger-confirmed products and feedback-corrected PCA-assembled DNA targets, establishing a verifiable route to autonomous experimentation. Together, these results show that the evaluation framework captures execution-relevant requirements for autonomous wet-lab automation, and that ProtoPilot can meet them by converting protocol and code generation into validated execution and feedback-guided revision.

Juncheng Ma, Yuxuan Du, Yanan Sun et al.

Diffusion Transformers (DiTs) have significantly advanced audio-driven portrait animation, but their high computational cost leads to substantial inference latency. Although training-free diffusion caching accelerates inference significant, existing methods are primarily developed for text-conditioned generation and overlook the spatial and modality imbalances inherent in audio-driven portrait animation. In this paper, we propose SyncCache, a training-free caching acceleration method tailored for DiT-based portrait animation that explicitly exploits asymmetric dynamics. Specifically, high-frequency dynamics driven by audio conditions and concentrated in human regions are more challenging and critical to cache and reuse than the low-frequency visual background in portrait animation. First, we introduce Spatially-Asymmetric Probing to prioritize error sensitivity in dynamic human region. Second, through Modality-Decoupled Caching, we bypass heavy DiT block by reusing stable inter-block residuals, while continuously recomputing lightweight audio blocks to preserve precise lip synchronization. Furthermore, we introduce a cache ratio to control cache capacity and formulate memory-adaptive cache selection as an offline dynamic programming problem without online overhead. Extensive experiments demonstrate that SyncCache achieves superior speed-quality trade-offs, delivering up to 4.12x acceleration on HunyuanVideo-Avatar and 3.75x on Wan-S2V with near-lossless visual fidelity and precise audio alignment.