Kai Ding

Mingxin Huang, Yuliang Liu, Zhenghao Peng et al.

End-to-end scene text spotting has attracted great attention in recent years due to the success of excavating the intrinsic synergy of the scene text detection and recognition. However, recent state-of-the-art methods usually incorporate detection and recognition simply by sharing the backbone, which does not directly take advantage of the feature interaction between the two tasks. In this paper, we propose a new end-to-end scene text spotting framework termed SwinTextSpotter. Using a transformer encoder with dynamic head as the detector, we unify the two tasks with a novel Recognition Conversion mechanism to explicitly guide text localization through recognition loss. The straightforward design results in a concise framework that requires neither additional rectification module nor character-level annotation for the arbitrarily-shaped text. Qualitative and quantitative experiments on multi-oriented datasets RoIC13 and ICDAR 2015, arbitrarily-shaped datasets Total-Text and CTW1500, and multi-lingual datasets ReCTS (Chinese) and VinText (Vietnamese) demonstrate SwinTextSpotter significantly outperforms existing methods. Code is available at https://github.com/mxin262/SwinTextSpotter.

Jiaxin Zhang, Canjie Luo, Lianwen Jin et al.

Camera-captured document images usually suffer from perspective and geometric deformations. It is of great value to rectify them when considering poor visual aesthetics and the deteriorated performance of OCR systems. Recent learning-based methods intensively focus on the accurately cropped document image. However, this might not be sufficient for overcoming practical challenges, including document images either with large marginal regions or without margins. Due to this impracticality, users struggle to crop documents precisely when they encounter large marginal regions. Simultaneously, dewarping images without margins is still an insurmountable problem. To the best of our knowledge, there is still no complete and effective pipeline for rectifying document images in the wild. To address this issue, we propose a novel approach called Marior (Margin Removal and \Iterative Content Rectification). Marior follows a progressive strategy to iteratively improve the dewarping quality and readability in a coarse-to-fine manner. Specifically, we divide the pipeline into two modules: margin removal module (MRM) and iterative content rectification module (ICRM). First, we predict the segmentation mask of the input image to remove the margin, thereby obtaining a preliminary result. Then we refine the image further by producing dense displacement flows to achieve content-aware rectification. We determine the number of refinement iterations adaptively. Experiments demonstrate the state-of-the-art performance of our method on public benchmarks. The resources are available at https://github.com/ZZZHANG-jx/Marior for further comparison.

Chongyu Liu, Lianwen Jin, Yuliang Liu et al.

Text removal has attracted increasingly attention due to its various applications on privacy protection, document restoration, and text editing. It has shown significant progress with deep neural network. However, most of the existing methods often generate inconsistent results for complex background. To address this issue, we propose a Contextual-guided Text Removal Network, termed as CTRNet. CTRNet explores both low-level structure and high-level discriminative context feature as prior knowledge to guide the process of background restoration. We further propose a Local-global Content Modeling (LGCM) block with CNNs and Transformer-Encoder to capture local features and establish the long-term relationship among pixels globally. Finally, we incorporate LGCM with context guidance for feature modeling and decoding. Experiments on benchmark datasets, SCUT-EnsText and SCUT-Syn show that CTRNet significantly outperforms the existing state-of-the-art methods. Furthermore, a qualitative experiment on examination papers also demonstrates the generalization ability of our method. The codes and supplement materials are available at https://github.com/lcy0604/CTRNet.

Jiahuan Cao, Dezhi Peng, Peirong Zhang et al.

Classical Chinese is a gateway to the rich heritage and wisdom of ancient China, yet its complexities pose formidable comprehension barriers for most modern people without specialized knowledge. While Large Language Models (LLMs) have shown remarkable capabilities in Natural Language Processing (NLP), they struggle with Classical Chinese Understanding (CCU), especially in data-demanding and knowledge-intensive tasks. In response to this dilemma, we propose \textbf{TongGu} (mean understanding ancient and modern), the first CCU-specific LLM, underpinned by three core contributions. First, we construct a two-stage instruction-tuning dataset ACCN-INS derived from rich classical Chinese corpora, aiming to unlock the full CCU potential of LLMs. Second, we propose Redundancy-Aware Tuning (RAT) to prevent catastrophic forgetting, enabling TongGu to acquire new capabilities while preserving its foundational knowledge. Third, we present a CCU Retrieval-Augmented Generation (CCU-RAG) technique to reduce hallucinations based on knowledge-grounding. Extensive experiments across 24 diverse CCU tasks validate TongGu's superior ability, underscoring the effectiveness of RAT and CCU-RAG. The model and dataset are available at \url{https://github.com/SCUT-DLVCLab/TongGu-LLM}.

Jiaxin Zhang, Bangdong Chen, Hiuyi Cheng et al.

Recently, there has been a growing interest in research concerning document image analysis and recognition in photographic scenarios. However, the lack of labeled datasets for this emerging challenge poses a significant obstacle, as manual annotation can be time-consuming and impractical. To tackle this issue, we present DocAligner, a novel method that streamlines the manual annotation process to a simple step of taking pictures. DocAligner achieves this by establishing dense correspondence between photographic document images and their clean counterparts. It enables the automatic transfer of existing annotations in clean document images to photographic ones and helps to automatically acquire labels that are unavailable through manual labeling. Considering the distinctive characteristics of document images, DocAligner incorporates several innovative features. First, we propose a non-rigid pre-alignment technique based on the document's edges, which effectively eliminates interference caused by significant global shifts and repetitive patterns present in document images. Second, to handle large shifts and ensure high accuracy, we introduce a hierarchical aligning approach that combines global and local correlation layers. Furthermore, considering the importance of fine-grained elements in document images, we present a details recurrent refinement module to enhance the output in a high-resolution space. To train DocAligner, we construct a synthetic dataset and introduce a self-supervised learning approach to enhance its robustness for real-world data. Through extensive experiments, we demonstrate the effectiveness of DocAligner and the acquired dataset. Datasets and codes will be publicly available.

Heng Xiong, Changrong Guo, Jian Peng et al.

Robotic object packing has broad practical applications in the logistics and automation industry, often formulated by researchers as the online 3D Bin Packing Problem (3D-BPP). However, existing DRL-based methods primarily focus on enhancing performance in limited packing environments while neglecting the ability to generalize across multiple environments characterized by different bin dimensions. To this end, we propose GOPT, a generalizable online 3D Bin Packing approach via Transformer-based deep reinforcement learning (DRL). First, we design a Placement Generator module to yield finite subspaces as placement candidates and the representation of the bin. Second, we propose a Packing Transformer, which fuses the features of the items and bin, to identify the spatial correlation between the item to be packed and available sub-spaces within the bin. Coupling these two components enables GOPT's ability to perform inference on bins of varying dimensions. We conduct extensive experiments and demonstrate that GOPT not only achieves superior performance against the baselines, but also exhibits excellent generalization capabilities. Furthermore, the deployment with a robot showcases the practical applicability of our method in the real world. The source code will be publicly available at https://github.com/Xiong5Heng/GOPT.

Kai Ding, Homayoun Yousefi'zadeh, Faryar Jabbari

Establishing robust connectivity in heterogeneous networks (HetNets) is an important yet challenging problem. For a HetNet accommodating a large number of nodes, establishing perturbation-invulnerable connectivity is of utmost importance. This paper provides a robust advantaged node placement strategy best suited for sparse network graphs. In order to offer connectivity robustness, this paper models the communication range of an advantaged node with a hexagon embedded within a circle representing the physical range of a node. Consequently, the proposed node placement method of this paper is based on a so-called hexagonal coordinate system (HCS) in which we develop an extended algebra. We formulate a class of geometric distance optimization problems aiming at establishing robust connectivity of a graph of multiple clusters of nodes. After showing that our formulated problem is NP-hard, we utilize HCS to efficiently solve an approximation of the problem. First, we show that our solution closely approximates an exhaustive search solution approach for the originally formulated NP-hard problem. Then, we illustrate its advantages in comparison with other alternatives through experimental results capturing advantaged node cost, runtime, and robustness characteristics. The results show that our algorithm is most effective in sparse networks for which we derive classification thresholds.

Junqi Liu, Zejun Wu, Pedro R. A. S. Bassi et al.

Image enhancement improves visual quality and helps reveal details that are hard to see in the original image. In medical imaging, it can support clinical decision-making, but current models often over-edit. This can distort organs, create false findings, and miss small tumors because these models do not understand anatomy or contrast dynamics. We propose SMILE, an anatomy-aware diffusion model that learns how organs are shaped and how they take up contrast. It enhances only clinically relevant regions while leaving all other areas unchanged. SMILE introduces three key ideas: (1) structure-aware supervision that follows true organ boundaries and contrast patterns; (2) registration-free learning that works directly with unaligned multi-phase CT scans; (3) unified inference that provides fast and consistent enhancement across all contrast phases. Across six external datasets, SMILE outperforms existing methods in image quality (14.2% higher SSIM, 20.6% higher PSNR, 50% better FID) and in clinical usefulness by producing anatomically accurate and diagnostically meaningful images. SMILE also improves cancer detection from non-contrast CT, raising the F1 score by up to 10 percent.

Huinan Xu, Xuyang Feng, Junhong Chen et al.

Current genomic foundation models (GFMs) rely on extensive neural computation to implicitly approximate conserved biological motifs from single-nucleotide inputs. We propose Gengram, a conditional memory module that introduces an explicit and highly efficient lookup primitive for multi-base motifs via a genomic-specific hashing scheme, establishing genomic "syntax". Integrated into the backbone of state-of-the-art GFMs, Gengram achieves substantial gains (up to 14%) across several functional genomics tasks. The module demonstrates robust architectural generalization, while further inspection of Gengram's latent space reveals the emergence of meaningful representations that align closely with fundamental biological knowledge. By establishing structured motif memory as a modeling primitive, Gengram simultaneously boosts empirical performance and mechanistic interpretability, providing a scalable and biology-aligned pathway for the next generation of GFMs. The code is available at https://github.com/zhejianglab/Genos, and the model checkpoint is available at https://huggingface.co/ZhejiangLab/Gengram.

Yang Liu, Jiahuan Cao, Chongyu Liu et al.

This paper embarks on an exploration into the Large Language Model (LLM) datasets, which play a crucial role in the remarkable advancements of LLMs. The datasets serve as the foundational infrastructure analogous to a root system that sustains and nurtures the development of LLMs. Consequently, examination of these datasets emerges as a critical topic in research. In order to address the current lack of a comprehensive overview and thorough analysis of LLM datasets, and to gain insights into their current status and future trends, this survey consolidates and categorizes the fundamental aspects of LLM datasets from five perspectives: (1) Pre-training Corpora; (2) Instruction Fine-tuning Datasets; (3) Preference Datasets; (4) Evaluation Datasets; (5) Traditional Natural Language Processing (NLP) Datasets. The survey sheds light on the prevailing challenges and points out potential avenues for future investigation. Additionally, a comprehensive review of the existing available dataset resources is also provided, including statistics from 444 datasets, covering 8 language categories and spanning 32 domains. Information from 20 dimensions is incorporated into the dataset statistics. The total data size surveyed surpasses 774.5 TB for pre-training corpora and 700M instances for other datasets. We aim to present the entire landscape of LLM text datasets, serving as a comprehensive reference for researchers in this field and contributing to future studies. Related resources are available at: https://github.com/lmmlzn/Awesome-LLMs-Datasets.

Wenxuan Li, Pedro R. A. S. Bassi, Lizhou Wu et al.

Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest solid malignancies, is often detected at a late and inoperable stage. Retrospective reviews of prediagnostic CT scans, when conducted by expert radiologists aware that the patient later developed PDAC, frequently reveal lesions that were previously overlooked. To help detecting these lesions earlier, we developed an automated system named ePAI (early Pancreatic cancer detection with Artificial Intelligence). It was trained on data from 1,598 patients from a single medical center. In the internal test involving 1,009 patients, ePAI achieved an area under the receiver operating characteristic curve (AUC) of 0.939-0.999, a sensitivity of 95.3%, and a specificity of 98.7% for detecting small PDAC less than 2 cm in diameter, precisely localizing PDAC as small as 2 mm. In an external test involving 7,158 patients across 6 centers, ePAI achieved an AUC of 0.918-0.945, a sensitivity of 91.5%, and a specificity of 88.0%, precisely localizing PDAC as small as 5 mm. Importantly, ePAI detected PDACs on prediagnostic CT scans obtained 3 to 36 months before clinical diagnosis that had originally been overlooked by radiologists. It successfully detected and localized PDACs in 75 of 159 patients, with a median lead time of 347 days before clinical diagnosis. Our multi-reader study showed that ePAI significantly outperformed 30 board-certified radiologists by 50.3% (P < 0.05) in sensitivity while maintaining a comparable specificity of 95.4% in detecting PDACs early and prediagnostic. These findings suggest its potential of ePAI as an assistive tool to improve early detection of pancreatic cancer.

Yong Xien Chng, Xuchong Qiu, Yizeng Han et al.

Despite extensive research, open-vocabulary segmentation methods still struggle to generalize across diverse domains. To reduce the computational cost of adapting Vision-Language Models (VLMs) while preserving their pre-trained knowledge, most methods freeze the VLMs for mask classification and train only the mask generator. However, our comprehensive analysis reveals a surprising insight: open-vocabulary segmentation is primarily bottlenecked by mask classification, not mask generation. This discovery prompts us to rethink the existing paradigm and explore an alternative approach. Instead of freezing the VLM, we propose to freeze the pre-trained mask generator and focus on optimizing the mask classifier. Building on the observation that VLMs pre-trained on global-pooled image-text features often fail to capture fine-grained semantics necessary for effective mask classification, we propose a novel Fine-grained Semantic Adaptation (FISA) method to address this limitation. FISA enhances the extracted visual features with fine-grained semantic awareness by explicitly integrating this crucial semantic information early in the visual encoding process. As our method strategically optimizes only a small portion of the VLM's parameters, it enjoys the efficiency of adapting to new data distributions while largely preserving the valuable VLM pre-trained knowledge. Extensive ablation studies confirm the superiority of our approach. Notably, FISA achieves new state-of-the-art results across multiple representative benchmarks, improving performance by up to +1.0 PQ and +3.0 mIoU and reduces training costs by nearly 5x compared to previous best methods. Our code and data will be made public.

Yi Luo, Yike Guo, Hamed Hooshangnejad et al.

Lung nodule detection in chest CT is crucial for early lung cancer diagnosis, yet existing deep learning approaches face challenges when deployed in clinical settings with limited annotated data. While curriculum learning has shown promise in improving model training, traditional static curriculum strategies fail in data-scarce scenarios. We propose Scale Adaptive Curriculum Learning (SACL), a novel training strategy that dynamically adjusts curriculum design based on available data scale. SACL introduces three key mechanisms:(1) adaptive epoch scheduling, (2) hard sample injection, and (3) scale-aware optimization. We evaluate SACL on the LUNA25 dataset using YOLOv11 as the base detector. Experimental results demonstrate that while SACL achieves comparable performance to static curriculum learning on the full dataset in mAP50, it shows significant advantages under data-limited conditions with 4.6%, 3.5%, and 2.0% improvements over baseline at 10%, 20%, and 50% of training data respectively. By enabling robust training across varying data scales without architectural modifications, SACL provides a practical solution for healthcare institutions to develop effective lung nodule detection systems despite limited annotation resources.

Hongliang Li, Jiaxin Zhang, Wenhui Liao et al.

Current Multimodal Large Language Model (MLLM) architectures face a critical tradeoff between performance and efficiency: decoder-only architectures achieve higher performance but lower efficiency, while cross-attention-based architectures offer greater efficiency but lower performance. The key distinction lies in how visual tokens are processed. Decoder-only architectures apply self-attention and FFN operations on visual tokens, while cross-attention architectures skip these computations. To investigate whether redundancy exists in this computationally expensive process, we propose a training-free framework for analyzing trained MLLMs. It consists of Probe-Activated Dynamic FFN and Hollow Attention, which enable adjustable reductions in computations for visual tokens, as well as a Layer Ranking Algorithm that prioritizes layers for these reductions. Extensive experiments demonstrate substantial, structured, and clustered redundancy unique to decoder-only MLLMs, offering valuable insights for future MLLM architecture design. Furthermore, by leveraging our reduction framework as a training-free inference acceleration approach, we achieve performance comparable to or better than state-of-the-art methods while remaining compatible with them. Code will be publicly available at https://github.com/L-Hugh/RedundancyLens.

Peirong Zhang, Kai Ding, Lianwen Jin

In this paper, we propose SPECTRUM, a temporal-frequency synergistic model that unlocks the untapped potential of multi-domain representation learning for online handwriting verification (OHV). SPECTRUM comprises three core components: (1) a multi-scale interactor that finely combines temporal and frequency features through dual-modal sequence interaction and multi-scale aggregation, (2) a self-gated fusion module that dynamically integrates global temporal and frequency features via self-driven balancing. These two components work synergistically to achieve micro-to-macro spectral-temporal integration. (3) A multi-domain distance-based verifier then utilizes both temporal and frequency representations to improve discrimination between genuine and forged handwriting, surpassing conventional temporal-only approaches. Extensive experiments demonstrate SPECTRUM's superior performance over existing OHV methods, underscoring the effectiveness of temporal-frequency multi-domain learning. Furthermore, we reveal that incorporating multiple handwritten biometrics fundamentally enhances the discriminative power of handwriting representations and facilitates verification. These findings not only validate the efficacy of multi-domain learning in OHV but also pave the way for future research in multi-domain approaches across both feature and biometric domains. Code is publicly available at https://github.com/NiceRingNode/SPECTRUM.

Hiuyi Cheng, Peirong Zhang, Sihang Wu et al.

Document layout analysis is a crucial prerequisite for document understanding, including document retrieval and conversion. Most public datasets currently contain only PDF documents and lack realistic documents. Models trained on these datasets may not generalize well to real-world scenarios. Therefore, this paper introduces a large and diverse document layout analysis dataset called $M^{6}Doc$. The $M^6$ designation represents six properties: (1) Multi-Format (including scanned, photographed, and PDF documents); (2) Multi-Type (such as scientific articles, textbooks, books, test papers, magazines, newspapers, and notes); (3) Multi-Layout (rectangular, Manhattan, non-Manhattan, and multi-column Manhattan); (4) Multi-Language (Chinese and English); (5) Multi-Annotation Category (74 types of annotation labels with 237,116 annotation instances in 9,080 manually annotated pages); and (6) Modern documents. Additionally, we propose a transformer-based document layout analysis method called TransDLANet, which leverages an adaptive element matching mechanism that enables query embedding to better match ground truth to improve recall, and constructs a segmentation branch for more precise document image instance segmentation. We conduct a comprehensive evaluation of $M^{6}Doc$ with various layout analysis methods and demonstrate its effectiveness. TransDLANet achieves state-of-the-art performance on $M^{6}Doc$ with 64.5% mAP. The $M^{6}Doc$ dataset will be available at https://github.com/HCIILAB/M6Doc.

Jiapeng Wang, Lianwen Jin, Kai Ding

Structured document understanding has attracted considerable attention and made significant progress recently, owing to its crucial role in intelligent document processing. However, most existing related models can only deal with the document data of specific language(s) (typically English) included in the pre-training collection, which is extremely limited. To address this issue, we propose a simple yet effective Language-independent Layout Transformer (LiLT) for structured document understanding. LiLT can be pre-trained on the structured documents of a single language and then directly fine-tuned on other languages with the corresponding off-the-shelf monolingual/multilingual pre-trained textual models. Experimental results on eight languages have shown that LiLT can achieve competitive or even superior performance on diverse widely-used downstream benchmarks, which enables language-independent benefit from the pre-training of document layout structure. Code and model are publicly available at https://github.com/jpWang/LiLT.

Dezhi Peng, Zhenhua Yang, Jiaxin Zhang et al.

In recent years, the optical character recognition (OCR) field has been proliferating with plentiful cutting-edge approaches for a wide spectrum of tasks. However, these approaches are task-specifically designed with divergent paradigms, architectures, and training strategies, which significantly increases the complexity of research and maintenance and hinders the fast deployment in applications. To this end, we propose UPOCR, a simple-yet-effective generalist model for Unified Pixel-level OCR interface. Specifically, the UPOCR unifies the paradigm of diverse OCR tasks as image-to-image transformation and the architecture as a vision Transformer (ViT)-based encoder-decoder. Learnable task prompts are introduced to push the general feature representations extracted by the encoder toward task-specific spaces, endowing the decoder with task awareness. Moreover, the model training is uniformly aimed at minimizing the discrepancy between the generated and ground-truth images regardless of the inhomogeneity among tasks. Experiments are conducted on three pixel-level OCR tasks including text removal, text segmentation, and tampered text detection. Without bells and whistles, the experimental results showcase that the proposed method can simultaneously achieve state-of-the-art performance on three tasks with a unified single model, which provides valuable strategies and insights for future research on generalist OCR models. Code will be publicly available.

Wenxuan Li, Pedro R. A. S. Bassi, Tianyu Lin et al.

Building trusted datasets is critical for transparent and responsible Medical AI (MAI) research, but creating even small, high-quality datasets can take years of effort from multidisciplinary teams. This process often delays AI benefits, as human-centric data creation and AI-centric model development are treated as separate, sequential steps. To overcome this, we propose ScaleMAI, an agent of AI-integrated data curation and annotation, allowing data quality and AI performance to improve in a self-reinforcing cycle and reducing development time from years to months. We adopt pancreatic tumor detection as an example. First, ScaleMAI progressively creates a dataset of 25,362 CT scans, including per-voxel annotations for benign/malignant tumors and 24 anatomical structures. Second, through progressive human-in-the-loop iterations, ScaleMAI provides Flagship AI Model that can approach the proficiency of expert annotators (30-year experience) in detecting pancreatic tumors. Flagship Model significantly outperforms models developed from smaller, fixed-quality datasets, with substantial gains in tumor detection (+14%), segmentation (+5%), and classification (72%) on three prestigious benchmarks. In summary, ScaleMAI transforms the speed, scale, and reliability of medical dataset creation, paving the way for a variety of impactful, data-driven applications.

Hamed Hooshangnejad, Xue Feng, Gaofeng Huang et al.

Lung cancer is a devastating disease with the highest mortality rate among cancer types. Over 60% of non-small cell lung cancer (NSCLC) patients, which accounts for 87% of diagnoses, require radiation therapy. Rapid treatment initiation significantly increases the patient's survival rate and reduces the mortality rate. Accurate tumor segmentation is a critical step in the diagnosis and treatment of NSCLC. Manual segmentation is time and labor-consuming and causes delays in treatment initiation. Although many lung nodule detection methods, including deep learning-based models, have been proposed, there is still a long-standing problem of high false positives (FPs) with most of these methods. Here, we developed an electronic health record (EHR) guided lung tumor auto-segmentation called EXACT-Net (EHR-enhanced eXACtitude in Tumor segmentation), where the extracted information from EHRs using a pre-trained large language model (LLM), was used to remove the FPs and keep the TP nodules only. The auto-segmentation model was trained on NSCLC patients' computed tomography (CT), and the pre-trained LLM was used with the zero-shot learning approach. Our approach resulted in a 250% boost in successful nodule detection using the data from ten NSCLC patients treated in our institution.

Wenxuan Li, Xinze Zhou, Qi Chen et al.

PanTS is a large-scale, multi-institutional dataset curated to advance research in pancreatic CT analysis. It contains 36,390 CT scans from 145 medical centers, with expert-validated, voxel-wise annotations of over 993,000 anatomical structures, covering pancreatic tumors, pancreas head, body, and tail, and 24 surrounding anatomical structures such as vascular/skeletal structures and abdominal/thoracic organs. Each scan includes metadata such as patient age, sex, diagnosis, contrast phase, in-plane spacing, slice thickness, etc. AI models trained on PanTS achieve significantly better performance in pancreatic tumor detection, localization, and segmentation compared to those trained on existing public datasets. Our analysis indicates that these gains are directly attributable to the 16x larger-scale tumor annotations and indirectly supported by the 24 additional surrounding anatomical structures. As the largest and most comprehensive resource of its kind, PanTS offers a new benchmark for developing and evaluating AI models in pancreatic CT analysis.

Yi Luo, Hamed Hooshangnejad, Xue Feng et al.

Background: Lung cancer ranks as the leading cause of cancer-related mortality worldwide. The complexity of tumor delineation, crucial for radiation therapy, requires expertise often unavailable in resource-limited settings. Artificial Intelligence(AI), particularly with advancements in deep learning (DL) and natural language processing (NLP), offers potential solutions yet is challenged by high false positive rates. Purpose: The Oncology Contouring Copilot (OCC) system is developed to leverage oncologist expertise for precise tumor contouring using textual descriptions, aiming to increase the efficiency of oncological workflows by combining the strengths of AI with human oversight. Methods: Our OCC system initially identifies nodule candidates from CT scans. Employing Language Vision Models (LVMs) like GPT-4V, OCC then effectively reduces false positives with clinical descriptive texts, merging textual and visual data to automate tumor delineation, designed to elevate the quality of oncology care by incorporating knowledge from experienced domain experts. Results: Deployments of the OCC system resulted in a significant reduction in the false discovery rate by 35.0%, a 72.4% decrease in false positives per scan, and an F1-score of 0.652 across our dataset for unbiased evaluation. Conclusions: OCC represents a significant advance in oncology care, particularly through the use of the latest LVMs to improve contouring results by (1) streamlining oncology treatment workflows by optimizing tumor delineation, reducing manual processes; (2) offering a scalable and intuitive framework to reduce false positives in radiotherapy planning using LVMs; (3) introducing novel medical language vision prompt techniques to minimize LVMs hallucinations with ablation study, and (4) conducting a comparative analysis of LVMs, highlighting their potential in addressing medical language vision challenges.

Junqi Liu, Xinze Zhou, Wenxuan Li et al.

Photon-counting CT (PCCT) provides superior image quality with higher spatial resolution and lower noise compared to conventional energy-integrating CT (EICT), but its limited clinical availability restricts large-scale research and clinical deployment. To bridge this gap, we propose SUMI, a simulated degradation-to-enhancement method that learns to reverse realistic acquisition artifacts in low-quality EICT by leveraging high-quality PCCT as reference. Our central insight is to explicitly model realistic acquisition degradations, transforming PCCT into clinically plausible lower-quality counterparts and learning to invert this process. The simulated degradations were validated for clinical realism by board-certified radiologists, enabling faithful supervision without requiring paired acquisitions at scale. As outcomes of this technical contribution, we: (1) train a latent diffusion model on 1,046 PCCTs, using an autoencoder first pre-trained on both these PCCTs and 405,379 EICTs from 145 hospitals to extract general CT latent features that we release for reuse in other generative medical imaging tasks; (2) construct a large-scale dataset of over 17,316 publicly available EICTs enhanced to PCCT-like quality, with radiologist-validated voxel-wise annotations of airway trees, arteries, veins, lungs, and lobes; and (3) demonstrate substantial improvements: across external data, SUMI outperforms state-of-the-art image translation methods by 15% in SSIM and 20% in PSNR, improves radiologist-rated clinical utility in reader studies, and enhances downstream top-ranking lesion detection performance, increasing sensitivity by up to 15% and F1 score by up to 10%. Our results suggest that emerging imaging advances can be systematically distilled into routine EICT using limited high-quality scans as reference.

Tianyu Lin, Xinran Li, Chuntung Zhuang et al.

Widely adopted evaluation metrics for sparse-view CT reconstruction--such as Structural Similarity Index Measure and Peak Signal-to-Noise Ratio--prioritize pixel-wise fidelity but often fail to capture the completeness of critical anatomical structures, particularly small or thin regions that are easily missed. To address this limitation, we propose a suite of novel anatomy-aware evaluation metrics designed to assess structural completeness across anatomical structures, including large organs, small organs, intestines, and vessels. Building on these metrics, we introduce CARE, a Completeness-Aware Reconstruction Enhancement framework that incorporates structural penalties during training to encourage anatomical preservation of significant structures. CARE is model-agnostic and can be seamlessly integrated into analytical, implicit, and generative methods. When applied to these methods, CARE substantially improves structural completeness in CT reconstructions, achieving up to +32% improvement for large organs, +22% for small organs, +40% for intestines, and +36% for vessels.

Yi Luo, Yike Guo, Hamed Hooshangnejad et al.

Lung cancer remains the leading cause of cancerrelated deaths globally. Accurate delineation of internal gross tumor volume (IGTV) in PET/CT imaging is pivotal for optimal radiation therapy in mobile tumors such as lung cancer to account for tumor motion, yet is hindered by the limited availability of annotated IGTV datasets and attenuated PET signal intensity at tumor boundaries. In this study, we present a transfer learningbased methodology utilizing a multimodal interactive perception network with MAMBA, pre-trained on extensive gross tumor volume (GTV) datasets and subsequently fine-tuned on a private IGTV cohort. This cohort constitutes the PET/CT subset of the Lung-cancer Unified Cross-modal Imaging Dataset (LUCID). To further address the challenge of weak PET intensities in IGTV peripheral slices, we introduce a slice interaction module (SIM) within a 2.5D segmentation framework to effectively model inter-slice relationships. Our proposed module integrates channel and spatial attention branches with depthwise convolutions, enabling more robust learning of slice-to-slice dependencies and thereby improving overall segmentation performance. A comprehensive experimental evaluation demonstrates that our approach achieves a Dice of 0.609 on the private IGTV dataset, substantially surpassing the conventional baseline score of 0.385. This work highlights the potential of transfer learning, coupled with advanced multimodal techniques and a SIM to enhance the reliability and clinical relevance of IGTV segmentation for lung cancer radiation therapy planning.

Shijia Zhang, Xiyu Ding, Kai Ding et al.

Identifying immune checkpoint inhibitor (ICI) studies in genomic repositories like Gene Expression Omnibus (GEO) is vital for cancer research yet remains challenging due to semantic ambiguity, extreme class imbalance, and limited labeled data in low-resource settings. We present ProtoBERT-LoRA, a hybrid framework that combines PubMedBERT with prototypical networks and Low-Rank Adaptation (LoRA) for efficient fine-tuning. The model enforces class-separable embeddings via episodic prototype training while preserving biomedical domain knowledge. Our dataset was divided as: Training (20 positive, 20 negative), Prototype Set (10 positive, 10 negative), Validation (20 positive, 200 negative), and Test (71 positive, 765 negative). Evaluated on test dataset, ProtoBERT-LoRA achieved F1-score of 0.624 (precision: 0.481, recall: 0.887), outperforming the rule-based system, machine learning baselines and finetuned PubMedBERT. Application to 44,287 unlabeled studies reduced manual review efforts by 82%. Ablation studies confirmed that combining prototypes with LoRA improved performance by 29% over stand-alone LoRA.

Xingyu Lu, Xiaonan Li, Qinyuan Cheng et al.

Fact knowledge memorization is crucial for Large Language Models (LLM) to generate factual and reliable responses. However, the behaviors of LLM fact memorization remain under-explored. In this paper, we analyze the scaling laws for LLM's fact knowledge and LLMs' behaviors of memorizing different types of facts. We find that LLMs' fact knowledge capacity has a linear and negative exponential law relationship with model size and training epochs, respectively. Estimated by the built scaling law, memorizing the whole Wikidata's facts requires training an LLM with 1000B non-embed parameters for 100 epochs, suggesting that using LLMs to memorize all public facts is almost implausible for a general pre-training setting. Meanwhile, we find that LLMs can generalize on unseen fact knowledge and its scaling law is similar to general pre-training. Additionally, we analyze the compatibility and preference of LLMs' fact memorization. For compatibility, we find LLMs struggle with memorizing redundant facts in a unified way. Only when correlated facts have the same direction and structure, the LLM can compatibly memorize them. This shows the inefficiency of LLM memorization for redundant facts. For preference, the LLM pays more attention to memorizing more frequent and difficult facts, and the subsequent facts can overwrite prior facts' memorization, which significantly hinders low-frequency facts memorization. Our findings reveal the capacity and characteristics of LLMs' fact knowledge learning, which provide directions for LLMs' fact knowledge augmentation.

Jiapeng Wang, Tianwei Wang, Guozhi Tang et al.

Visual information extraction (VIE) has attracted increasing attention in recent years. The existing methods usually first organized optical character recognition (OCR) results into plain texts and then utilized token-level entity annotations as supervision to train a sequence tagging model. However, it expends great annotation costs and may be exposed to label confusion, and the OCR errors will also significantly affect the final performance. In this paper, we propose a unified weakly-supervised learning framework called TCPN (Tag, Copy or Predict Network), which introduces 1) an efficient encoder to simultaneously model the semantic and layout information in 2D OCR results; 2) a weakly-supervised training strategy that utilizes only key information sequences as supervision; and 3) a flexible and switchable decoder which contains two inference modes: one (Copy or Predict Mode) is to output key information sequences of different categories by copying a token from the input or predicting one in each time step, and the other (Tag Mode) is to directly tag the input sequence in a single forward pass. Our method shows new state-of-the-art performance on several public benchmarks, which fully proves its effectiveness.

Michael Beyer, Andrey Morozov, Emil Valiev et al.

Today, Deep Learning (DL) enhances almost every industrial sector, including safety-critical areas. The next generation of safety standards will define appropriate verification techniques for DL-based applications and propose adequate fault tolerance mechanisms. DL-based applications, like any other software, are susceptible to common random hardware faults such as bit flips, which occur in RAM and CPU registers. Such faults can lead to silent data corruption. Therefore, it is crucial to develop methods and tools that help to evaluate how DL components operate under the presence of such faults. In this paper, we introduce two new Fault Injection (FI) frameworks InjectTF and InjectTF2 for TensorFlow 1 and TensorFlow 2, respectively. Both frameworks are available on GitHub and allow the configurable injection of random faults into Neural Networks (NN). In order to demonstrate the feasibility of the frameworks, we also present the results of FI experiments conducted on four VGG-based Convolutional NNs using two image sets. The results demonstrate how random bit flips in the output of particular mathematical operations and layers of NNs affect the classification accuracy. These results help to identify the most critical operations and layers, compare the reliability characteristics of functionally similar NNs, and introduce selective fault tolerance mechanisms.

Khaled S. Refaat, Kai Ding, Natalia Ponomareva et al.

In autonomous navigation, a planning system reasons about other agents to plan a safe and plausible trajectory. Before planning starts, agents are typically processed with computationally intensive models for recognition, tracking, motion estimation and prediction. With limited computational resources and a large number of agents to process in real time, it becomes important to efficiently rank agents according to their impact on the decision making process. This allows spending more time processing the most important agents. We propose a system to rank agents around an autonomous vehicle (AV) in real time. We automatically generate a ranking data set by running the planner in simulation on real-world logged data, where we can afford to run more accurate and expensive models on all the agents. The causes of various planner actions are logged and used for assigning ground truth importance scores. The generated data set can be used to learn ranking models. In particular, we show the utility of combining learned features, via a convolutional neural network, with engineered features designed to capture domain knowledge. We show the benefits of various design choices experimentally. When tested on real AVs, our system demonstrates the capability of understanding complex driving situations.