Shan Zhong, Gokberk Kabacaoglu, George Biros
Numerical simulation of deformable particle suspensions in Stokes flow is computationally expensive due to nonlinear fluid-structure interactions, evolving interfaces, and multiscale hydrodynamics. We present VesNet, a hybrid framework that accelerates two-dimensional vesicle suspension simulations by approximating vesicle self interactions, including background flow coupling and short-range lubrication forces, while retaining conventional modules for boundary reparameterization and far-field hydrodynamics. A GPU-accelerated implementation achieves over 100x speedup compared to a multithreaded MATLAB CPU boundary integral solver and about 5x relative to its GPU counterpart. VesNet accurately captures key dynamics, including single-vesicle phase behavior, pair interactions, and large-scale suspensions in Taylor-Green and Poiseuille flows, enabling efficient simulations of thousands of vesicles on modest computational resources.