Changhui Li

Shuang Li, Yibing Wang, Jian Gao et al.

Large-scale 3D photoacoustic (PA) imaging has become increasingly important for both clinical and pre-clinical applications. Limited by cost and system complexity, only systems with sparsely-distributed sensors can be widely implemented, which desires advanced reconstruction algorithms to reduce artifacts. However, high computing memory and time consumption of traditional iterative reconstruction (IR) algorithms is practically unacceptable for large-scale 3D PA imaging. Here, we propose a point cloud-based IR algorithm that reduces memory consumption by several orders, wherein the 3D PA scene is modeled as a series of Gaussian-distributed spherical sources stored in form of point cloud. During the IR process, not only are properties of each Gaussian source, including its peak intensity (initial pressure value), standard deviation (size) and mean (position) continuously optimized, but also each Gaussian source itself adaptively undergoes destroying, splitting, and duplication along the gradient direction. This method, named the sliding Gaussian ball adaptive growth (SlingBAG) algorithm, enables high-quality large-scale 3D PA reconstruction with fast iteration and extremely low memory usage. We validated SlingBAG algorithm in both simulation study and in vivo animal experiments. The source code and data for SlingBAG, along with supplementary materials and demonstration videos, are now available in the following GitHub repository: https://github.com/JaegerCQ/SlingBAG.

Shuang Li, Yibing Wang, Jian Gao et al.

Large-scale dynamic three-dimensional (3D) photoacoustic imaging (PAI) is significantly important in clinical applications. In practical implementations, large-scale 3D real-time PAI systems typically utilize sparse two-dimensional (2D) sensor arrays with certain angular deficiencies, necessitating advanced iterative reconstruction (IR) algorithms to achieve quantitative PAI and reduce reconstruction artifacts. However, for existing IR algorithms, multi-frame 3D reconstruction leads to extremely high memory consumption and prolonged computation time, with limited consideration of the spatial-temporal continuity between data frames. Here, we propose a novel method, named the 4D sliding Gaussian ball adaptive growth (4D SlingBAG) algorithm, based on the current point cloud-based IR algorithm sliding Gaussian ball adaptive growth (SlingBAG), which has minimal memory consumption among IR methods. Our 4D SlingBAG method applies spatial-temporal coupled deformation functions to each Gaussian sphere in point cloud, thus explicitly learning the deformations features of the dynamic 3D PA scene. This allows for the efficient representation of various physiological processes (such as pulsation) or external pressures (e.g., blood perfusion experiments) contributing to changes in vessel morphology and blood flow during dynamic 3D PAI, enabling highly efficient IR for dynamic 3D PAI. Simulation experiments demonstrate that 4D SlingBAG achieves high-quality dynamic 3D PA reconstruction. Compared to performing reconstructions by using SlingBAG algorithm individually for each frame, our method significantly reduces computational time and keeps a extremely low memory consumption. The project for 4D SlingBAG can be found in the following GitHub repository: \href{https://github.com/JaegerCQ/4D-SlingBAG}{https://github.com/JaegerCQ/4D-SlingBAG}.

Shuang Li, Qian Chen, Chulhong Kim et al.

Photoacoustic imaging (PAI) uniquely combines optical contrast with the penetration depth of ultrasound, making it critical for clinical applications. However, the quality of 3D PAI is often degraded due to reconstruction artifacts caused by the sparse and angle-limited configuration of detector arrays. Existing iterative or deep learning-based methods are either time-consuming or require large training datasets, significantly limiting their practical application. Here, we propose Zero-Shot Artifact2Artifact (ZS-A2A), a zero-shot self-supervised artifact removal method based on a super-lightweight network, which leverages the fact that reconstruction artifacts are sensitive to irregularities caused by data loss. By introducing random perturbations to the acquired PA data, it spontaneously generates subset data, which in turn stimulates the network to learn the artifact patterns in the reconstruction results, thus enabling zero-shot artifact removal. This approach requires neither training data nor prior knowledge of the artifacts, and is capable of artifact removal for 3D PAI. For maximum amplitude projection (MAP) images or slice images in 3D PAI acquired with arbitrarily sparse or angle-limited detector arrays, ZS-A2A employs a self-incentive strategy to complete artifact removal and improves the Contrast-to-Noise Ratio (CNR). We validated ZS-A2A in both simulation study and $ in\ vivo $ animal experiments. Results demonstrate that ZS-A2A achieves state-of-the-art (SOTA) performance compared to existing zero-shot methods, and for the $ in\ vivo $ rat liver, ZS-A2A improves CNR from 17.48 to 43.46 in just 8 seconds. The project for ZS-A2A will be available in the following GitHub repository: https://github.com/JaegerCQ/ZS-A2A.