Zongyuan Ge

Dwarikanath Mahapatra, Abhijit Das, Behzad Bozorgtabar et al.

Multimodal medical imaging fuses complementary anatomical and functional information, yet modalities frequently disagree in pathologically heterogeneous regions. Current segmentation models handle this in one of two inadequate ways: deterministic fusion that averages away disagreement, or post-hoc uncertainty estimation decoupled from the fusion process that produces it. Both obscure the clinically critical question: why is this prediction unreliable? We present EnTrust, a framework that treats inter-modal conflict as the primary source of predictive uncertainty. Our EnFuse module decomposes multimodal features into three disentangled components: shared anatomical consensus (F_c), modality-specific cues (F_{u,m}), and spatially localized conflict signals (F_{cf}), with independence enforced via a cross-covariance objective. This structured decomposition conditions SegDiff, a diffusion-based generative segmentation model whose sampled hypotheses diverge specifically in regions of modal disagreement. TrustMap then translates this hypothesis divergence into calibrated, pixel-wise uncertainty using ensemble entropy, conflict-guided perturbation probing, and a learned calibration head, enabling clinicians to understand not only where predictions are uncertain, but why. Across four benchmarks spanning brain, cardiac, lesion, and oncology domains, EnTrust achieves state-of-the-art segmentation accuracy while reducing calibration error by 40% compared to the strongest baseline. Notably, it outperforms 5x deep ensembles using a single model at roughly half the memory footprint. Code and checkpoints are available at https://github.com/GenMI-Lab/EnTrust.git.

Talha Ilyas, Deval Mehta, Zongyuan Ge

Video-based seizure detection is essential for the management of epilepsy patients, offering a non-invasive complement to electroencephalography. While several deep learning approaches have been developed for video-based seizure detection, none are inherently interpretable, limiting their adoption and translation into clinical practice. We present, to our knowledge, the first exploration of a neurosymbolic framework for video-based seizure detection that directly addresses this gap. Our approach (1) extracts patient-centric skeleton sequences from epilepsy monitoring units via a prompt-guided foundation model, (2) predicts binary spatio-temporal concept activations grounded in clinical motor semiology guidelines, and (3) composes them via differentiable logic into interpretable Boolean rules with auditable contributions. Furthermore, to mitigate false positives arising from the traditional binary formulation (seizure vs.\ non-seizure), we sub-classify non-seizure segments into clinically relevant normal activities, providing the model with fine-grained discriminative supervision. Evaluated on two public seizure video benchmarks, our framework achieves 89.78% sensitivity with 0.06 false detections per hour on SAHZU and 85.27%,0.09 on IEEE, while producing complete three-level interpretability: every prediction decomposes into which motor primitives were detected, how they were logically composed, and how much each rule contributed to the clinical decision. We publicly release all annotations, extracted pose sequences, our data pipeline and code, https://github.com/Mr-TalhaIlyas/CDSD/.

Yaling Shen, Maja Christensen, Yiwen Jiang et al.

Dementia diagnosis requires integrating multi-modal clinical assessments from diverse informants and clinicians under incomplete and heterogeneous data conditions. Yet most AI-driven approaches remain Alzheimer's disease (AD)-centric, framing the problem as binary AD detection or three-stage AD progression modeling within well-curated research settings. This pathology-driven paradigm overlooks the broader, syndrome-level nature of dementia, which spans multiple stages, phenotypes, and etiologies. In this paper, we propose Dementia-Agents, a clinically aligned multi-agent framework for real-world dementia staging and phenotyping. The framework follows a three-step workflow: (1) a data agent translates structured clinical records into semantically faithful textual representations that preserve missing-data signals and routes them to domain-aligned experts; (2) five fine-tuned expert agents generate domain-level predictions; and (3) a coordinator agent performs probabilistic aggregation to produce final staging and phenotyping decisions. We develop and evaluate Dementia-Agents on a real-world clinical cohort of 1,066 patients from two cognitive neurology services. Compared with monolithic multi-modal large language models (MLLMs) and prior medical multi-agent systems, our approach achieves consistent improvements in diagnostic performance for real-world syndrome-level dementia staging and phenotyping, while preserving domain-level interpretability.