Wei Liu

Changda Chen, Yichen Yang, Wei Liu et al.

This paper proposes a geometrically constrained decentralized independent vector analysis (GC-Dec-IVA) method for distributed microphone arrays. Recently proposed Dec-IVA method enables source separation by exchanging only power-related statistics to exploit cross-array information. However, this initial attempt often provides negligible improvement over applying IVA locally at each array, mainly due to the potential permutation inconsistency among arrays and the strong cross-array dependency implied by its source model. To address these limitations, we incorporate direction-of-arrival (DOA) information to derive GC-Dec-IVA, which mitigates permutation mismatch across arrays and enhances source alignment. Furthermore, a new source model is introduced to weaken cross-array dependency, improving robustness against permutation inconsistency in noisy environments. Experiments show the proposed method improves both the separation performance and cross-array permutation consistency.

Ziyang Dong, Shanwen Tan, Hengchuang Yin et al.

Motivation: Gene regulatory network inference from single-cell RNA sequencing (scRNA-seq) data is important for uncovering cell-state-specific transcriptional programs. However, scRNA-seq measurements are sparse and noisy, and experimentally validated TF-target interactions remain limited, making reliable inference challenging. Although graph neural networks have advanced GRN prediction, existing methods often rely on biologically unconstrained graph augmentation, such as random edge perturbation, and insufficiently control information transfer between genes and cells. These limitations may distort regulatory structures and weaken robustness under noisy and weakly supervised settings. Results: To address these issues, we propose an innovative framework named Biological Evidence Refinement and Heterogeneous Dynamic Gating for Gene Regulatory Networks (BRIDGE). BRIDGE extracts gene and cell representations from the expression matrix and its matrix dual, and performs contrastive learning in the gene space and cell space between self and neighbors across the co-expression-refined regulatory view and the original graph. It then applies heterogeneous gated encoding to adaptively regulate information transfer between genes and cells, enabling robust transcription factor-to-target gene prediction. Experiments on benchmark datasets spanning three network types and seven cell types show that BRIDGE achieves state-of-the-art AUROC and AUPRC in most settings. In particular, on Specific networks, BRIDGE improves average AUPRC by 5% over the second-best baseline, GCLink. In cross-cell-type few-shot transfer, BRIDGE consistently outperforms GCLink and GENELink across all six target cell types. A case study on hESC further supports the biological relevance of the predictions, with 9 of the top 10 and 46 of the top 100 novel TF-target interactions validated by ChIPBase.