Wenhao Zheng

Jinhong Wang, Jingwen Wang, Tingting Chen et al.

Surgery is the only viable treatment for cataract patients with visual acuity (VA) impairment. Clinically, to assess the necessity of cataract surgery, accurately predicting postoperative VA before surgery by analyzing multi-view optical coherence tomography (OCT) images is crucially needed. Unfortunately, due to complicated fundus conditions, determining postoperative VA remains difficult for medical experts. Deep learning methods for this problem were developed in recent years. Although effective, these methods still face several issues, such as not efficiently exploring potential relations between multi-view OCT images, neglecting the key role of clinical prior knowledge (e.g., preoperative VA value), and using only regression-based metrics which are lacking reference. In this paper, we propose a novel Cross-token Transformer Network (CTT-Net) for postoperative VA prediction by analyzing both the multi-view OCT images and preoperative VA. To effectively fuse multi-view features of OCT images, we develop cross-token attention that could restrict redundant/unnecessary attention flow. Further, we utilize the preoperative VA value to provide more information for postoperative VA prediction and facilitate fusion between views. Moreover, we design an auxiliary classification loss to improve model performance and assess VA recovery more sufficiently, avoiding the limitation by only using the regression metrics. To evaluate CTT-Net, we build a multi-view OCT image dataset collected from our collaborative hospital. A set of extensive experiments validate the effectiveness of our model compared to existing methods in various metrics. Code is available at: https://github.com/wjh892521292/Cataract OCT.

Wenhao Zheng, Yixiao Chen, Weitong Zhang et al.

Large language models have achieved remarkable success in various tasks but suffer from high computational costs during inference, limiting their deployment in resource-constrained applications. To address this issue, we propose a novel Collaborative Inference with Token-lEvel Routing (CITER) framework that enables efficient collaboration between small and large language models (SLMs \& LLMs) through a token-level routing strategy. Specifically, CITER routes non-critical tokens to an SLM for efficiency and routes critical tokens to an LLM for generalization quality. We formulate router training as a policy optimization, where the router receives rewards based on both the quality of predictions and the inference costs of generation. This allows the router to learn to predict token-level routing scores and make routing decisions based on both the current token and the future impact of its decisions. To further accelerate the reward evaluation process, we introduce a shortcut which significantly reduces the costs of the reward estimation and improving the practicality of our approach. Extensive experiments on five benchmark datasets demonstrate that CITER reduces the inference costs while preserving high-quality generation, offering a promising solution for real-time and resource-constrained applications. Our data and code are available at https://github.com/aiming-lab/CITER.

Zhaoyang Wang, Jinqi Jiang, Huichi Zhou et al.

Recent Large Language Models (LLMs) have demonstrated satisfying general instruction following ability. However, small LLMs with about 7B parameters still struggle fine-grained format following (e.g., JSON format), which seriously hinder the advancements of their applications. Most existing methods focus on benchmarking general instruction following while overlook how to improve the specific format following ability for small LLMs. Besides, these methods often rely on evaluations based on advanced LLMs (e.g., GPT-4), which can introduce the intrinsic bias of LLMs and be costly due to the API calls. In this paper, we first curate a fully verifiable format following dataset VFF. In contrast to existing works often adopting external LLMs for instruction-following validations, every sample of VFF can be easily validated with a Python function. Further, we propose to leverage this verifiable feature to synthesize massive data for progressively training small LLMs, in order to improve their format following abilities. Experimental results highlight the prevalent limitations in the format following capabilities of 7B level open-source LLMs and demonstrate the effectiveness of our method in enhancing this essential ability.

Han Zhang, Zihao Zhang, Wenhao Zheng et al.

A major challenge in image segmentation is classifying object boundaries. Recent efforts propose to refine the segmentation result with boundary masks. However, models are still prone to misclassifying boundary pixels even when they correctly capture the object contours. In such cases, even a perfect boundary map is unhelpful for segmentation refinement. In this paper, we argue that assigning proper prior weights to error-prone pixels such as object boundaries can significantly improve the segmentation quality. Specifically, we present the \textit{pixel null model} (PNM), a prior model that weights each pixel according to its probability of being correctly classified by a random segmenter. Empirical analysis shows that PNM captures the misclassification distribution of different state-of-the-art (SOTA) segmenters. Extensive experiments on semantic, instance, and panoptic segmentation tasks over three datasets (Cityscapes, ADE20K, MS COCO) confirm that PNM consistently improves the segmentation quality of most SOTA methods (including the vision transformers) and outperforms boundary-based methods by a large margin. We also observe that the widely-used mean IoU (mIoU) metric is insensitive to boundaries of different sharpness. As a byproduct, we propose a new metric, \textit{PNM IoU}, which perceives the boundary sharpness and better reflects the model segmentation performance in error-prone regions.

Wenhao Zheng, Chenwei Sun, Wenbo Zhang et al.

Deep generative models, such as diffusion models, have shown promising progress in image generation and audio generation via simplified continuity assumptions. However, the development of generative modeling techniques for generating multi-modal data, such as parametric CAD sequences, still lags behind due to the challenges in addressing long-range constraints and parameter sensitivity. In this work, we propose a novel framework for quantitatively constrained CAD generation, termed Target-Guided Bayesian Flow Network (TGBFN). For the first time, TGBFN handles the multi-modality of CAD sequences (i.e., discrete commands and continuous parameters) in a unified continuous and differentiable parameter space rather than in the discrete data space. In addition, TGBFN penetrates the parameter update kernel and introduces a guided Bayesian flow to control the CAD properties. To evaluate TGBFN, we construct a new dataset for quantitatively constrained CAD generation. Extensive comparisons across single-condition and multi-condition constrained generation tasks demonstrate that TGBFN achieves state-of-the-art performance in generating high-fidelity, condition-aware CAD sequences. The code is available at https://github.com/scu-zwh/TGBFN.

Peng Xia, Ming Hu, Feilong Tang et al.

Diabetic Retinopathy (DR), induced by diabetes, poses a significant risk of visual impairment. Accurate and effective grading of DR aids in the treatment of this condition. Yet existing models experience notable performance degradation on unseen domains due to domain shifts. Previous methods address this issue by simulating domain style through simple visual transformation and mitigating domain noise via learning robust representations. However, domain shifts encompass more than image styles. They overlook biases caused by implicit factors such as ethnicity, age, and diagnostic criteria. In our work, we propose a novel framework where representations of paired data from different domains are decoupled into semantic features and domain noise. The resulting augmented representation comprises original retinal semantics and domain noise from other domains, aiming to generate enhanced representations aligned with real-world clinical needs, incorporating rich information from diverse domains. Subsequently, to improve the robustness of the decoupled representations, class and domain prototypes are employed to interpolate the disentangled representations while data-aware weights are designed to focus on rare classes and domains. Finally, we devise a robust pixel-level semantic alignment loss to align retinal semantics decoupled from features, maintaining a balance between intra-class diversity and dense class features. Experimental results on multiple benchmarks demonstrate the effectiveness of our method on unseen domains. The code implementations are accessible on https://github.com/richard-peng-xia/DECO.

Peng Xia, Siwei Han, Shi Qiu et al. · microsoft-research

Interleaved multimodal comprehension and generation, enabling models to produce and interpret both images and text in arbitrary sequences, have become a pivotal area in multimodal learning. Despite significant advancements, the evaluation of this capability remains insufficient. Existing benchmarks suffer from limitations in data scale, scope, and evaluation depth, while current evaluation metrics are often costly or biased, lacking in reliability for practical applications. To address these challenges, we introduce MMIE, a large-scale knowledge-intensive benchmark for evaluating interleaved multimodal comprehension and generation in Large Vision-Language Models (LVLMs). MMIE comprises 20K meticulously curated multimodal queries, spanning 3 categories, 12 fields, and 102 subfields, including mathematics, coding, physics, literature, health, and arts. It supports both interleaved inputs and outputs, offering a mix of multiple-choice and open-ended question formats to evaluate diverse competencies. Moreover, we propose a reliable automated evaluation metric, leveraging a scoring model fine-tuned with human-annotated data and systematic evaluation criteria, aimed at reducing bias and improving evaluation accuracy. Extensive experiments demonstrate the effectiveness of our benchmark and metrics in providing a comprehensive evaluation of interleaved LVLMs. Specifically, we evaluate eight LVLMs, revealing that even the best models show significant room for improvement, with most achieving only moderate results. We believe MMIE will drive further advancements in the development of interleaved LVLMs. We publicly release our benchmark and code in https://mmie-bench.github.io/.

Yiyang Zhou, Zhaoyang Wang, Tianle Wang et al.

High-quality preference data is essential for aligning foundation models with human values through preference learning. However, manual annotation of such data is often time-consuming and costly. Recent methods often adopt a self-rewarding approach, where the target model generates and annotates its own preference data, but this can lead to inaccuracies since the reward model shares weights with the target model, thereby amplifying inherent biases. To address these issues, we propose Anyprefer, a framework designed to synthesize high-quality preference data for aligning the target model. Anyprefer frames the data synthesis process as a cooperative two-player Markov Game, where the target model and the judge model collaborate together. Here, a series of external tools are introduced to assist the judge model in accurately rewarding the target model's responses, mitigating biases in the rewarding process. In addition, a feedback mechanism is introduced to optimize prompts for both models, enhancing collaboration and improving data quality. The synthesized data is compiled into a new preference dataset, Anyprefer-V1, consisting of 58K high-quality preference pairs. Extensive experiments show that Anyprefer significantly improves model alignment performance across four main applications, covering 21 datasets, achieving average improvements of 18.55% in five natural language generation datasets, 3.66% in nine vision-language understanding datasets, 30.05% in three medical image analysis datasets, and 16.00% in four visuo-motor control tasks.

Wenhao Zheng, Liaoyaqi Wang, Dongshen Peng et al.

The clinical trial is a pivotal and costly process, often spanning multiple years and requiring substantial financial resources. Therefore, the development of clinical trial outcome prediction models aims to exclude drugs likely to fail and holds the potential for significant cost savings. Recent data-driven attempts leverage deep learning methods to integrate multimodal data for predicting clinical trial outcomes. However, these approaches rely on manually designed modal-specific encoders, which limits both the extensibility to adapt new modalities and the ability to discern similar information patterns across different modalities. To address these issues, we propose a multimodal mixture-of-experts (LIFTED) approach for clinical trial outcome prediction. Specifically, LIFTED unifies different modality data by transforming them into natural language descriptions. Then, LIFTED constructs unified noise-resilient encoders to extract information from modal-specific language descriptions. Subsequently, a sparse Mixture-of-Experts framework is employed to further refine the representations, enabling LIFTED to identify similar information patterns across different modalities and extract more consistent representations from those patterns using the same expert model. Finally, a mixture-of-experts module is further employed to dynamically integrate different modality representations for prediction, which gives LIFTED the ability to automatically weigh different modalities and pay more attention to critical information. The experiments demonstrate that LIFTED significantly enhances performance in predicting clinical trial outcomes across all three phases compared to the best baseline, showcasing the effectiveness of our proposed key components.

Xiangyu Wang, Donglin Yang, Yue Liao et al.

Unmanned Aerial Vehicles (UAVs) are evolving into language-interactive platforms, enabling more intuitive forms of human-drone interaction. While prior works have primarily focused on high-level planning and long-horizon navigation, we shift attention to language-guided fine-grained trajectory control, where UAVs execute short-range, reactive flight behaviors in response to language instructions. We formalize this problem as the Flying-on-a-Word (Flow) task and introduce UAV imitation learning as an effective approach. In this framework, UAVs learn fine-grained control policies by mimicking expert pilot trajectories paired with atomic language instructions. To support this paradigm, we present UAV-Flow, the first real-world benchmark for language-conditioned, fine-grained UAV control. It includes a task formulation, a large-scale dataset collected in diverse environments, a deployable control framework, and a simulation suite for systematic evaluation. Our design enables UAVs to closely imitate the precise, expert-level flight trajectories of human pilots and supports direct deployment without sim-to-real gap. We conduct extensive experiments on UAV-Flow, benchmarking VLN and VLA paradigms. Results show that VLA models are superior to VLN baselines and highlight the critical role of spatial grounding in the fine-grained Flow setting.

Jianshu She, Wenhao Zheng, Zhengzhong Liu et al.

The computational complexity of large language model (LLM) inference significantly constrains their deployment efficiency on edge devices. In contrast, small language models offer faster decoding and lower resource consumption but often suffer from degraded response quality and heightened susceptibility to hallucinations. To address this trade-off, collaborative decoding, in which a large model assists in generating critical tokens, has emerged as a promising solution. This paradigm leverages the strengths of both model types by enabling high-quality inference through selective intervention of the large model, while maintaining the speed and efficiency of the smaller model. In this work, we present a novel collaborative decoding inference system that allows small models to perform on-device inference while selectively consulting a cloud-based large model for critical token generation. Remarkably, the system achieves a 60% performance gain on CommonsenseQA using only a 0.5B model on an M1 MacBook, with under 7% of tokens generation uploaded to the large model in the cloud.

Zhijian Feng, Wenhao Zheng, Xuanji Xiao

In real-world recommendation systems, users would engage in variety scenarios, such as homepages, search pages, and related recommendation pages. Each of these scenarios would reflect different aspects users focus on. However, the user interests may be inconsistent in different scenarios, due to differences in decision-making processes and preference expression. This variability complicates unified modeling, making multi-scenario learning a significant challenge. To address this, we propose a novel reinforcement learning approach that models user preferences across scenarios by modeling user interest evolution across multiple scenarios. Our method employs Double Q-learning to enhance next-item prediction accuracy and optimizes contrastive learning loss using Q-value to make model performance better. Experimental results demonstrate that our approach surpasses state-of-the-art methods in multi-scenario recommendation tasks. Our work offers a fresh perspective on multi-scenario modeling and highlights promising directions for future research.

Peng Xia, Ze Chen, Juanxi Tian et al.

Artificial intelligence has significantly impacted medical applications, particularly with the advent of Medical Large Vision Language Models (Med-LVLMs), sparking optimism for the future of automated and personalized healthcare. However, the trustworthiness of Med-LVLMs remains unverified, posing significant risks for future model deployment. In this paper, we introduce CARES and aim to comprehensively evaluate the Trustworthiness of Med-LVLMs across the medical domain. We assess the trustworthiness of Med-LVLMs across five dimensions, including trustfulness, fairness, safety, privacy, and robustness. CARES comprises about 41K question-answer pairs in both closed and open-ended formats, covering 16 medical image modalities and 27 anatomical regions. Our analysis reveals that the models consistently exhibit concerns regarding trustworthiness, often displaying factual inaccuracies and failing to maintain fairness across different demographic groups. Furthermore, they are vulnerable to attacks and demonstrate a lack of privacy awareness. We publicly release our benchmark and code in https://cares-ai.github.io/.

Yi Cheng, Haochao Ying, Renjun Hu et al.

Image ordinal regression has been mainly studied along the line of exploiting the order of categories. However, the issues of class imbalance and category overlap that are very common in ordinal regression were largely overlooked. As a result, the performance on minority categories is often unsatisfactory. In this paper, we propose a novel framework called CIG based on controllable image generation to directly tackle these two issues. Our main idea is to generate extra training samples with specific labels near category boundaries, and the sample generation is biased toward the less-represented categories. To achieve controllable image generation, we seek to separate structural and categorical information of images based on structural similarity, categorical similarity, and reconstruction constraints. We evaluate the effectiveness of our new CIG approach in three different image ordinal regression scenarios. The results demonstrate that CIG can be flexibly integrated with off-the-shelf image encoders or ordinal regression models to achieve improvement, and further, the improvement is more significant for minority categories.

Zhijun Zeng, Zhen Hou, Ting Li et al.

We develop a deep learning approach to predicting a set of ventilator parameters for a mechanically ventilated septic patient using a long and short term memory (LSTM) recurrent neural network (RNN) model. We focus on short-term predictions of a set of ventilator parameters for the septic patient in emergency intensive care unit (EICU). The short-term predictability of the model provides attending physicians with early warnings to make timely adjustment to the treatment of the patient in the EICU. The patient specific deep learning model can be trained on any given critically ill patient, making it an intelligent aide for physicians to use in emergent medical situations.

Han Zhang, Wenhao Zheng, Charley Chen et al.

Since the label collecting is prohibitive and time-consuming, unsupervised methods are preferred in applications such as fraud detection. Meanwhile, such applications usually require modeling the intrinsic clusters in high-dimensional data, which usually displays heterogeneous statistical patterns as the patterns of different clusters may appear in different dimensions. Existing methods propose to model the data clusters on selected dimensions, yet globally omitting any dimension may damage the pattern of certain clusters. To address the above issues, we propose a novel unsupervised generative framework called FIRD, which utilizes adversarial distributions to fit and disentangle the heterogeneous statistical patterns. When applying to discrete spaces, FIRD effectively distinguishes the synchronized fraudsters from normal users. Besides, FIRD also provides superior performance on anomaly detection datasets compared with SOTA anomaly detection methods (over 5% average AUC improvement). The significant experiment results on various datasets verify that the proposed method can better model the heterogeneous statistical patterns in high-dimensional data and benefit downstream applications.

He Huang, Yuanwei Chen, Wei Tang et al.

Multi-label zero-shot classification aims to predict multiple unseen class labels for an input image. It is more challenging than its single-label counterpart. On one hand, the unconstrained number of labels assigned to each image makes the model more easily overfit to those seen classes. On the other hand, there is a large semantic gap between seen and unseen classes in the existing multi-label classification datasets. To address these difficult issues, this paper introduces a novel multi-label zero-shot classification framework by learning to transfer from external knowledge. We observe that ImageNet is commonly used to pretrain the feature extractor and has a large and fine-grained label space. This motivates us to exploit it as external knowledge to bridge the seen and unseen classes and promote generalization. Specifically, we construct a knowledge graph including not only classes from the target dataset but also those from ImageNet. Since ImageNet labels are not available in the target dataset, we propose a novel PosVAE module to infer their initial states in the extended knowledge graph. Then we design a relational graph convolutional network (RGCN) to propagate information among classes and achieve knowledge transfer. Experimental results on two benchmark datasets demonstrate the effectiveness of the proposed approach.

Shu-Ting Shi, Wenhao Zheng, Jun Tang et al.

Click-through rate (CTR) prediction is an essential task in industrial applications such as video recommendation. Recently, deep learning models have been proposed to learn the representation of users' overall interests, while ignoring the fact that interests may dynamically change over time. We argue that it is necessary to consider the continuous-time information in CTR models to track user interest trend from rich historical behaviors. In this paper, we propose a novel Deep Time-Stream framework (DTS) which introduces the time information by an ordinary differential equations (ODE). DTS continuously models the evolution of interests using a neural network, and thus is able to tackle the challenge of dynamically representing users' interests based on their historical behaviors. In addition, our framework can be seamlessly applied to any existing deep CTR models by leveraging the additional Time-Stream Module, while no changes are made to the original CTR models. Experiments on public dataset as well as real industry dataset with billions of samples demonstrate the effectiveness of proposed approaches, which achieve superior performance compared with existing methods.

Ya-Lin Zhang, Jun Zhou, Wenhao Zheng et al.

Internet companies are facing the need for handling large-scale machine learning applications on a daily basis and distributed implementation of machine learning algorithms which can handle extra-large scale tasks with great performance is widely needed. Deep forest is a recently proposed deep learning framework which uses tree ensembles as its building blocks and it has achieved highly competitive results on various domains of tasks. However, it has not been tested on extremely large scale tasks. In this work, based on our parameter server system, we developed the distributed version of deep forest. To meet the need for real-world tasks, many improvements are introduced to the original deep forest model, including MART (Multiple Additive Regression Tree) as base learners for efficiency and effectiveness consideration, the cost-based method for handling prevalent class-imbalanced data, MART based feature selection for high dimension data and different evaluation metrics for automatically determining of the cascade level. We tested the deep forest model on an extra-large scale task, i.e., automatic detection of cash-out fraud, with more than 100 millions of training samples. Experimental results showed that the deep forest model has the best performance according to the evaluation metrics from different perspectives even with very little effort for parameter tuning. This model can block fraud transactions in a large amount of money each day. Even compared with the best-deployed model, the deep forest model can additionally bring into a significant decrease in economic loss each day.

Wenhao Zheng, Hong-Yu Zhou, Ming Li et al.

Appropriate comments of code snippets provide insight for code functionality, which are helpful for program comprehension. However, due to the great cost of authoring with the comments, many code projects do not contain adequate comments. Automatic comment generation techniques have been proposed to generate comments from pieces of code in order to alleviate the human efforts in annotating the code. Most existing approaches attempt to exploit certain correlations (usually manually given) between code and generated comments, which could be easily violated if the coding patterns change and hence the performance of comment generation declines. In this paper, we first build C2CGit, a large dataset from open projects in GitHub, which is more than 20$\times$ larger than existing datasets. Then we propose a new attention module called Code Attention to translate code to comments, which is able to utilize the domain features of code snippets, such as symbols and identifiers. We make ablation studies to determine effects of different parts in Code Attention. Experimental results demonstrate that the proposed module has better performance over existing approaches in both BLEU and METEOR.