Xin Xia

Yujian Liu, Xiao Yu, Jacky Keung et al.

Large language models (LLMs) have rapidly evolved from general-purpose systems to multimodal models capable of processing text, images, and audio. As both general-purpose LLMs (GLLMs) and multimodal LLMs (MLLMs) gain widespread adoption, understanding user perceptions in real-world settings becomes increasingly important. However, existing studies often rely on surveys or platform-specific data (e.g., Reddit or GitHub issues), which either constrain user feedback through predefined questions or overemphasize failure-driven, debugging-oriented discussions, thus failing to capture diverse, experience-driven, and cross-model user perspectives in practice. To address this issue, we conduct an empirical study of user discussions on Hugging Face, a major model hub with diverse models and active communities. We collect and manually annotate 662 discussion threads from 38 representative models (21 GLLMs and 17 MLLMs), and develop a three-level taxonomy to systematically characterize user concerns. Our analysis reveals that LLM access barriers, generation quality, and deployment and invocation complexity are the most prominent concerns, alongside issues such as documentation limitations and resource constraints. Based on these findings, we derive actionable implications for improving LLM ecosystem.

Sixue Xing, Xuanye Xia, Kerui Wu et al.

Clinical trial failure remains a central bottleneck in drug development, where minor protocol design flaws can irreversibly compromise outcomes despite promising therapeutics. Although cutting-edge AI methods achieve strong performance in predicting trial success, they are inherently reactive for merely diagnosing risk without offering actionable remedies once failure is anticipated. To fill this gap, this paper proposes ClinicalReTrial, a self-evolving AI agent framework that addresses this gap by casting clinical trial reasoning as an iterative protocol redesign problem. Our method integrates failure diagnosis, safety-aware modification, and candidate evaluation in a closed-loop, reward-driven optimization framework. Serving the outcome prediction model as a simulation environment, ClinicalReTrial enables low-cost evaluation of protocol modifications and provides dense reward signals for continuous self-improvement. To support efficient exploration, the framework maintains hierarchical memory that captures iteration-level feedback within trials and distills transferable redesign patterns across trials. Empirically, ClinicalReTrial improves 83.3% of trial protocols with a mean success probability gain of 5.7%, and retrospective case studies demonstrate strong alignment between the discovered redesign strategies and real-world clinical trial modifications.

Xinyu Xia, Xingjun Ma, Yunfeng Hu et al.

Ensuring robust and generalizable autonomous driving requires not only broad scenario coverage but also efficient repair of failure cases, particularly those related to challenging and safety-critical scenarios. However, existing scenario generation and selection methods often lack adaptivity and semantic relevance, limiting their impact on performance improvement. In this paper, we propose \textbf{SERA}, an LLM-powered framework that enables autonomous driving systems to self-evolve by repairing failure cases through targeted scenario recommendation. By analyzing performance logs, SERA identifies failure patterns and dynamically retrieves semantically aligned scenarios from a structured bank. An LLM-based reflection mechanism further refines these recommendations to maximize relevance and diversity. The selected scenarios are used for few-shot fine-tuning, enabling targeted adaptation with minimal data. Experiments on the benchmark show that SERA consistently improves key metrics across multiple autonomous driving baselines, demonstrating its effectiveness and generalizability under safety-critical conditions.