Mehmet Kemal Özdemir

Gulsade Rabia Cakmak, Ibrahim Ethem Hamamci, Mehmet Kursat Yilmaz et al.

The postoperative range of motion is one of the crucial factors indicating the outcome of Total Knee Arthroplasty (TKA). Although the correlation between range of knee flexion and posterior condylar offset (PCO) is controversial in the literature, PCO maintains its importance on evaluation of TKA. Due to limitations on PCO measurement, two novel parameters, posterior condylar offset ratio (PCOR) and anterior condylar offset ratio (ACOR), were introduced. Nowadays, the calculation of PCOR and ACOR on plain lateral radiographs is done manually by orthopedic surgeons. In this regard, we developed a software, AutoCOR, to calculate PCOR and ACOR autonomously, utilizing unsupervised machine learning algorithm (k-means clustering) and digital image processing techniques. The software AutoCOR is capable of detecting the anterior/posterior edge points and anterior/posterior cortex of the femoral shaft on true postoperative lateral conventional radiographs. To test the algorithm, 50 postoperative true lateral radiographs from Istanbul Kosuyolu Medipol Hospital Database were used (32 patients). The mean PCOR was 0.984 (SD 0.235) in software results and 0.972 (SD 0.164) in ground truth values. It shows strong and significant correlation between software and ground truth values (Pearson r=0.845 p<0.0001). The mean ACOR was 0.107 (SD 0.092) in software results and 0.107 (SD 0.070) in ground truth values. It shows moderate and significant correlation between software and ground truth values (Spearman's rs=0.519 p=0.0001412). We suggest that AutoCOR is a useful tool that can be used in clinical practice.

Ibrahim Ethem Hamamci, Sezgin Er, Chenyu Wang et al.

Advancements in medical imaging AI, particularly in 3D imaging, have been limited due to the scarcity of comprehensive datasets. We introduce CT-RATE, a public dataset that pairs 3D medical images with corresponding textual reports. CT-RATE comprises 25,692 non-contrast 3D chest CT scans from 21,304 unique patients. Each scan is accompanied by its corresponding radiology report. Leveraging CT-RATE, we develop CT-CLIP, a CT-focused contrastive language-image pretraining framework designed for broad applications without the need for task-specific training. We demonstrate how CT-CLIP can be used in multi-abnormality detection and case retrieval, and outperforms state-of-the-art fully supervised models across all key metrics. By combining CT-CLIP's vision encoder with a pretrained large language model, we create CT-CHAT, a vision-language foundational chat model for 3D chest CT volumes. Finetuned on over 2.7 million question-answer pairs derived from the CT-RATE dataset, CT-CHAT underscores the necessity for specialized methods in 3D medical imaging. Collectively, the open-source release of CT-RATE, CT-CLIP, and CT-CHAT not only addresses critical challenges in 3D medical imaging but also lays the groundwork for future innovations in medical AI and improved patient care.

Murong Xu, Tamaz Amiranashvili, Fernando Navarro et al.

Accurate delineation of anatomical structures in volumetric CT scans is crucial for diagnosis and treatment planning. While AI has advanced automated segmentation, current approaches typically target individual structures, creating a fragmented landscape of incompatible models with varying performance and disparate evaluation protocols. Foundational segmentation models address these limitations by providing a holistic anatomical view through a single model. Yet, robust clinical deployment demands comprehensive training data, which is lacking in existing whole-body approaches, both in terms of data heterogeneity and, more importantly, anatomical coverage. In this work, rather than pursuing incremental optimizations in model architecture, we present CADS, an open-source framework that prioritizes the systematic integration, standardization, and labeling of heterogeneous data sources for whole-body CT segmentation. At its core is a large-scale dataset of 22,022 CT volumes with complete annotations for 167 anatomical structures, representing a significant advancement in both scale and coverage, with 18 times more scans than existing collections and 60% more distinct anatomical targets. Building on this diverse dataset, we develop the CADS-model using established architectures for accessible and automated full-body CT segmentation. Through comprehensive evaluation across 18 public datasets and an independent real-world hospital cohort, we demonstrate advantages over SoTA approaches. Notably, thorough testing of the model's performance in segmentation tasks from radiation oncology validates its direct utility for clinical interventions. By making our large-scale dataset, our segmentation models, and our clinical software tool publicly available, we aim to advance robust AI solutions in radiology and make comprehensive anatomical analysis accessible to clinicians and researchers alike.