Guangyu Guo

Sijing Li, Zhongwei Qiu, Jiang Liu et al.

Accurate tumor analysis is central to clinical radiology and precision oncology, where early detection, reliable lesion characterization, and pathology-level risk assessment guide diagnosis and treatment planning. Chain-of-Thought (CoT) reasoning is particularly important in this setting because it enables step-by-step interpretation from imaging findings to clinical impressions and pathology conclusions, improving traceability and reducing diagnostic errors. Here, we target the clinical tumor analysis task and build a large-scale benchmark that operationalizes a multimodal reasoning pipeline, spanning findings, impressions, and pathology predictions. We curate TumorCoT, a large-scale dataset of 1.5M CoT-labeled VQA instructions paired with 3D CT scans, with step-aligned rationales and cross-modal alignments along the trajectory from findings to impression to pathology, enabling evaluation of both answer accuracy and reasoning consistency. We further propose TumorChain, a multimodal interleaved reasoning framework that tightly couples 3D imaging encoders, clinical text understanding, and organ-level vision-language alignment. Through cross-modal alignment and iterative interleaved causal reasoning, TumorChain grounds visual evidence, aggregates conclusions, and issues pathology predictions after multiple rounds of self-refinement, improving traceability and reducing hallucination risk. Experiments show consistent improvements over strong baselines in lesion detection, impression generation, and pathology classification, and demonstrate strong generalization on the DeepTumorVQA benchmark. These results highlight the potential of multimodal reasoning for reliable and interpretable tumor analysis in clinical practice. Detailed information about our project can be found on our project homepage at https://github.com/ZJU4HealthCare/TumorChain.

Guangyu Guo, Dingwen Zhang, Longfei Han et al.

Previous knowledge distillation (KD) methods mostly focus on compressing network architectures, which is not thorough enough in deployment as some costs like transmission bandwidth and imaging equipment are related to the image size. Therefore, we propose Pixel Distillation that extends knowledge distillation into the input level while simultaneously breaking architecture constraints. Such a scheme can achieve flexible cost control for deployment, as it allows the system to adjust both network architecture and image quality according to the overall requirement of resources. Specifically, we first propose an input spatial representation distillation (ISRD) mechanism to transfer spatial knowledge from large images to student's input module, which can facilitate stable knowledge transfer between CNN and ViT. Then, a Teacher-Assistant-Student (TAS) framework is further established to disentangle pixel distillation into the model compression stage and input compression stage, which significantly reduces the overall complexity of pixel distillation and the difficulty of distilling intermediate knowledge. Finally, we adapt pixel distillation to object detection via an aligned feature for preservation (AFP) strategy for TAS, which aligns output dimensions of detectors at each stage by manipulating features and anchors of the assistant. Comprehensive experiments on image classification and object detection demonstrate the effectiveness of our method. Code is available at https://github.com/gyguo/PixelDistillation.

Guangyu Guo, Jiawen Yao, Yingda Xia et al.

The absence of adequately sufficient expert-level tumor annotations hinders the effectiveness of supervised learning based opportunistic cancer screening on medical imaging. Clinical reports (that are rich in descriptive textual details) can offer a "free lunch'' supervision information and provide tumor location as a type of weak label to cope with screening tasks, thus saving human labeling workloads, if properly leveraged. However, predicting cancer only using such weak labels can be very changeling since tumors are usually presented in small anatomical regions compared to the whole 3D medical scans. Weakly semi-supervised learning (WSSL) utilizes a limited set of voxel-level tumor annotations and incorporates alongside a substantial number of medical images that have only off-the-shelf clinical reports, which may strike a good balance between minimizing expert annotation workload and optimizing screening efficacy. In this paper, we propose a novel text-guided learning method to achieve highly accurate cancer detection results. Through integrating diagnostic and tumor location text prompts into the text encoder of a vision-language model (VLM), optimization of weakly supervised learning can be effectively performed in the latent space of VLM, thereby enhancing the stability of training. Our approach can leverage clinical knowledge by large-scale pre-trained VLM to enhance generalization ability, and produce reliable pseudo tumor masks to improve cancer detection. Our extensive quantitative experimental results on a large-scale cancer dataset, including 1,651 unique patients, validate that our approach can reduce human annotation efforts by at least 70% while maintaining comparable cancer detection accuracy to competing fully supervised methods (AUC value 0.961 versus 0.966).

Yang Jin, Guangyu Guo, Binglu Wang

Gaze object detection and gaze following are fundamental tasks for interpreting human gaze behavior or intent. However, most previous methods usually solve these two tasks separately, and their prediction of gaze objects and gaze following typically depend on head-related prior knowledge during both the training phase and real-world deployment. This dependency necessitates an auxiliary network to extract head location, thus precluding joint optimization across the entire system and constraining the practical applicability. To this end, we propose GaTector+, a unified framework for gaze object detection and gaze following, which eliminates the dependence on the head-related priors during inference. Specifically, GaTector+ uses an expanded specific-general-specific feature extractor that leverages a shared backbone, which extracts general features for gaze following and object detection using the shared backbone while using specific blocks before and after the shared backbone to better consider the specificity of each sub-task. To obtain head-related knowledge without prior information, we first embed a head detection branch to predict the head of each person. Then, before regressing the gaze point, a head-based attention mechanism is proposed to fuse the sense feature and gaze feature with the help of head location. Since the suboptimization of the gaze point heatmap leads to the performance bottleneck, we propose an attention supervision mechanism to accelerate the learning of the gaze heatmap. Finally, we propose a novel evaluation metric, mean Similarity over Candidates (mSoC), for gaze object detection, which is more sensitive to variations between bounding boxes. The experimental results on multiple benchmark datasets demonstrate the effectiveness of our model in both gaze object detection and gaze following tasks.

Dingwen Zhang, Wenyuan Zeng, Guangyu Guo et al.

Current weakly supervised semantic segmentation (WSSS) frameworks usually contain the separated mask-refinement model and the main semantic region mining model. These approaches would contain redundant feature extraction backbones and biased learning objectives, making them computational complex yet sub-optimal to addressing the WSSS task. To solve this problem, this paper establishes a compact learning framework that embeds the classification and mask-refinement components into a unified deep model. With the shared feature extraction backbone, our model is able to facilitate knowledge sharing between the two components while preserving a low computational complexity. To encourage high-quality knowledge interaction, we propose a novel alternative self-dual teaching (ASDT) mechanism. Unlike the conventional distillation strategy, the knowledge of the two teacher branches in our model is alternatively distilled to the student branch by a Pulse Width Modulation (PWM), which generates PW wave-like selection signal to guide the knowledge distillation process. In this way, the student branch can help prevent the model from falling into local minimum solutions caused by the imperfect knowledge provided of either teacher branch. Comprehensive experiments on the PASCAL VOC 2012 and COCO-Stuff 10K demonstrate the effectiveness of the proposed alternative self-dual teaching mechanism as well as the new state-of-the-art performance of our approach.