Gregory J. Czarnota

H. R. Tizhoosh, G. J. Czarnota

Marking tumors and organs is a challenging task suffering from both inter- and intra-observer variability. The literature quantifies observer variability by generating consensus among multiple experts when they mark the same image. Automatically building consensus contours to establish quality assurance for image segmentation is presently absent in the clinical practice. As the \emph{big data} becomes more and more available, techniques to access a large number of existing segments of multiple experts becomes possible. Fast algorithms are, hence, required to facilitate the search for similar cases. The present work puts forward a potential framework that tested with small datasets (both synthetic and real images) displays the reliability of finding similar images. In this paper, the idea of content-based barcodes is used to retrieve similar cases in order to build consensus contours in medical image segmentation. This approach may be regarded as an extension of the conventional atlas-based segmentation that generally works with rather small atlases due to required computational expenses. The fast segment-retrieval process via barcodes makes it possible to create and use large atlases, something that directly contributes to the quality of the consensus building. Because the accuracy of experts' contours must be measured, we first used 500 synthetic prostate images with their gold markers and delineations by 20 simulated users. The fast barcode-guided computed consensus delivered an average error of $8\%\!\pm\!5\%$ compared against the gold standard segments. Furthermore, we used magnetic resonance images of prostates from 15 patients delineated by 5 oncologists and selected the best delineations to serve as the gold-standard segments. The proposed barcode atlas achieved a Jaccard overlap of $87\%\!\pm\!9\%$ with the contours of the gold-standard segments.

Mehrdad J. Gangeh, Hamid R. Tizhoosh, Kan Wu et al.

Recent advances in using quantitative ultrasound (QUS) methods have provided a promising framework to non-invasively and inexpensively monitor or predict the effectiveness of therapeutic cancer responses. One of the earliest steps in using QUS methods is contouring a region of interest (ROI) inside the tumour in ultrasound B-mode images. While manual segmentation is a very time-consuming and tedious task for human experts, auto-contouring is also an extremely difficult task for computers due to the poor quality of ultrasound B-mode images. However, for the purpose of cancer response prediction, a rough boundary of the tumour as an ROI is only needed. In this research, a semi-automated tumour localization approach is proposed for ROI estimation in ultrasound B-mode images acquired from patients with locally advanced breast cancer (LABC). The proposed approach comprised several modules, including 1) feature extraction using keypoint descriptors, 2) augmenting the feature descriptors with the distance of the keypoints to the user-input pixel as the centre of the tumour, 3) supervised learning using a support vector machine (SVM) to classify keypoints as "tumour" or "non-tumour", and 4) computation of an ellipse as an outline of the ROI representing the tumour. Experiments with 33 B-mode images from 10 LABC patients yielded promising results with an accuracy of 76.7% based on the Dice coefficient performance measure. The results demonstrated that the proposed method can potentially be used as the first stage in a computer-assisted cancer response prediction system for semi-automated contouring of breast tumours.

Hamid R. Tizhoosh, Mehrdad J. Gangeh, Hadi Tadayyon et al.

Quantitative ultrasound (QUS) methods provide a promising framework that can non-invasively and inexpensively be used to predict or assess the tumour response to cancer treatment. The first step in using the QUS methods is to select a region of interest (ROI) inside the tumour in ultrasound images. Manual segmentation, however, is very time consuming and tedious. In this paper, a semi-automated approach will be proposed to roughly localize an ROI for a tumour in ultrasound images of patients with locally advanced breast cancer (LABC). Content-based barcodes, a recently introduced binary descriptor based on Radon transform, were used in order to find similar cases and estimate a bounding box surrounding the tumour. Experiments with 33 B-scan images resulted in promising results with an accuracy of $81\%$.