Xiaolong Qian

Qi Jiang, Yao Gao, Shaohua Gao et al.

Emerging universal Computational Aberration Correction (CAC) paradigms provide an inspiring solution to light-weight and high-quality imaging with a universal model trained on a lens library (LensLib) to address arbitrary lens optical aberrations blindly. However, the limited coverage of existing LensLibs leads to poor generalization of the trained models to unseen lenses, whose fine-tuning pipeline is also confined to the lens-descriptions-known case. In this work, we introduce OmniLens, a flexible solution to universal CAC via (i) establishing a convincing LensLib with comprehensive coverage for pre-training a robust base model, and (ii) adapting the model to any specific lens designs with unknown lens descriptions via fast LensLib-to-specific domain adaptation. To achieve these, an Evolution-based Automatic Optical Design (EAOD) pipeline is proposed to generate a rich variety of lens samples with realistic aberration behaviors. Then, we design an unsupervised regularization term for efficient domain adaptation on a few easily accessible real-captured images based on the statistical observation of dark channel priors in degradation induced by lens aberrations. Extensive experiments demonstrate that the LensLib generated by EAOD effectively develops a universal CAC model with strong generalization capabilities, which can also improve the non-blind lens-specific methods by 0.35~1.81dB in PSNR. Additionally, the proposed domain adaptation method significantly improves the base model, especially in severe aberration cases (at most 2.59dB in PSNR). The code and data will be available at https://github.com/zju-jiangqi/OmniLens.

Xiaolong Qian, Qi Jiang, Yao Gao et al.

Controllable Depth-of-Field (DoF) imaging commonly produces amazing visual effects based on heavy and expensive high-end lenses. However, confronted with the increasing demand for mobile scenarios, it is desirable to achieve a lightweight solution with Minimalist Optical Systems (MOS). This work centers around two major limitations of MOS, i.e., the severe optical aberrations and uncontrollable DoF, for achieving single-lens controllable DoF imaging via computational methods. A Depth-aware Controllable DoF Imaging (DCDI) framework is proposed equipped with All-in-Focus (AiF) aberration correction and monocular depth estimation, where the recovered image and corresponding depth map are utilized to produce imaging results under diverse DoFs of any high-end lens via patch-wise convolution. To address the depth-varying optical degradation, we introduce a Depth-aware Degradation-adaptive Training (DA2T) scheme. At the dataset level, a Depth-aware Aberration MOS (DAMOS) dataset is established based on the simulation of Point Spread Functions (PSFs) under different object distances. Additionally, we design two plug-and-play depth-aware mechanisms to embed depth information into the aberration image recovery for better tackling depth-aware degradation. Furthermore, we propose a storage-efficient Omni-Lens-Field model to represent the 4D PSF library of various lenses. With the predicted depth map, recovered image, and depth-aware PSF map inferred by Omni-Lens-Field, single-lens controllable DoF imaging is achieved. Comprehensive experimental results demonstrate that the proposed framework enhances the recovery performance, and attains impressive single-lens controllable DoF imaging results, providing a seminal baseline for this field. The source code and the established dataset will be publicly available at https://github.com/XiaolongQian/DCDI.

Xiaolong Qian, Qi Jiang, Yao Gao et al.

Prevalent Computational Aberration Correction (CAC) methods are typically tailored to specific optical systems, leading to poor generalization and labor-intensive re-training for new lenses. Developing CAC paradigms capable of generalizing across diverse photographic lenses offers a promising solution to these challenges. However, efforts to achieve such cross-lens universality within consumer photography are still in their early stages due to the lack of a comprehensive benchmark that encompasses a sufficiently wide range of optical aberrations. Furthermore, it remains unclear which specific factors influence existing CAC methods and how these factors affect their performance. In this paper, we present comprehensive experiments and evaluations involving 24 image restoration and CAC algorithms, utilizing our newly proposed UniCAC, a large-scale benchmark for photographic cameras constructed via automatic optical design. The Optical Degradation Evaluator (ODE) is introduced as a novel framework to objectively assess the difficulty of CAC tasks, offering credible quantification of optical aberrations and enabling reliable evaluation. Drawing on our comparative analysis, we identify three key factors -- prior utilization, network architecture, and training strategy -- that most significantly influence CAC performance, and further investigate their respective effects. We believe that our benchmark, dataset, and observations contribute foundational insights to related areas and lay the groundwork for future investigations. Benchmarks, codes, and Zemax files will be available at https://github.com/XiaolongQian/UniCAC.

Xiaojing Guo, Jiatai Lin, Yumian Jia et al.

Generalist pathology foundation models (PFMs), pretrained on large-scale multi-organ datasets, have demonstrated remarkable predictive capabilities across diverse clinical applications. However, their proficiency on the full spectrum of clinically essential tasks within a specific organ system remains an open question due to the lack of large-scale validation cohorts for a single organ as well as the absence of a tailored training paradigm that can effectively translate broad histomorphological knowledge into the organ-specific expertise required for specialist-level interpretation. In this study, we propose BRIGHT, the first PFM specifically designed for breast pathology, trained on approximately 210 million histopathology tiles from over 51,000 breast whole-slide images derived from a cohort of over 40,000 patients across 19 hospitals. BRIGHT employs a collaborative generalist-specialist framework to capture both universal and organ-specific features. To comprehensively evaluate the performance of PFMs on breast oncology, we curate the largest multi-institutional cohorts to date for downstream task development and evaluation, comprising over 25,000 WSIs across 10 hospitals. The validation cohorts cover the full spectrum of breast pathology across 24 distinct clinical tasks spanning diagnosis, biomarker prediction, treatment response and survival prediction. Extensive experiments demonstrate that BRIGHT outperforms three leading generalist PFMs, achieving state-of-the-art (SOTA) performance in 21 of 24 internal validation tasks and in 5 of 10 external validation tasks with excellent heatmap interpretability. By evaluating on large-scale validation cohorts, this study not only demonstrates BRIGHT's clinical utility in breast oncology but also validates a collaborative generalist-specialist paradigm, providing a scalable template for developing PFMs on a specific organ system.

Qi Jiang, Zhonghua Yi, Shaohua Gao et al.

Relying on paired synthetic data, existing learning-based Computational Aberration Correction (CAC) methods are confronted with the intricate and multifaceted synthetic-to-real domain gap, which leads to suboptimal performance in real-world applications. In this paper, in contrast to improving the simulation pipeline, we deliver a novel insight into real-world CAC from the perspective of Unsupervised Domain Adaptation (UDA). By incorporating readily accessible unpaired real-world data into training, we formalize the Domain Adaptive CAC (DACAC) task, and then introduce a comprehensive Real-world aberrated images (Realab) dataset to benchmark it. The setup task presents a formidable challenge due to the intricacy of understanding the target optical degradation domain. To this intent, we propose a novel Quantized Domain-Mixing Representation (QDMR) framework as a potent solution to the issue. Centering around representing and quantizing the optical degradation which is consistent across different images, QDMR adapts the CAC model to the target domain from three key aspects: (1) reconstructing aberrated images of both domains by a VQGAN to learn a Domain-Mixing Codebook (DMC) characterizing the optical degradation; (2) modulating the deep features in CAC model with DMC to transfer the target domain knowledge; and (3) leveraging the trained VQGAN to generate pseudo target aberrated images from the source ones for convincing target domain supervision. Extensive experiments on both synthetic and real-world benchmarks reveal that the models with QDMR consistently surpass the competitive methods in mitigating the synthetic-to-real gap, which produces visually pleasant real-world CAC results with fewer artifacts. Codes and datasets are made publicly available at https://github.com/zju-jiangqi/QDMR.

Xiaolong Qian, Qi Jiang, Lei Sun et al.

Beyond the commonly recognized optical aberrations, the imaging performance of compact optical systems-including single-lens and metalens designs-is often further degraded by veiling glare caused by stray-light scattering from non-ideal optical surfaces and coatings, particularly in complex real-world environments. This compound degradation undermines traditional lens aberration correction yet remains underexplored. A major challenge is that conventional scattering models (e.g., for dehazing) fail to fit veiling glare due to its spatial-varying and depth-independent nature. Consequently, paired high-quality data are difficult to prepare via simulation, hindering application of data-driven veiling glare removal models. To this end, we propose VeilGen, a generative model that learns to simulate veiling glare by estimating its underlying optical transmission and glare maps in an unsupervised manner from target images, regularized by Stable Diffusion (SD)-based priors. VeilGen enables paired dataset generation with realistic compound degradation of optical aberrations and veiling glare, while also providing the estimated latent optical transmission and glare maps to guide the veiling glare removal process. We further introduce DeVeiler, a restoration network trained with a reversibility constraint, which utilizes the predicted latent maps to guide an inverse process of the learned scattering model. Extensive experiments on challenging compact optical systems demonstrate that our approach delivers superior restoration quality and physical fidelity compared with existing methods. These suggest that VeilGen reliably synthesizes realistic veiling glare, and its learned latent maps effectively guide the restoration process in DeVeiler. All code and datasets will be publicly released at https://github.com/XiaolongQian/DeVeiler.

Qi Jiang, Xiaolong Qian, Yao Gao et al.

Emerging deep-learning-based lens library pre-training (LensLib-PT) pipeline offers a new avenue for blind lens aberration correction by training a universal neural network, demonstrating strong capability in handling diverse unknown optical degradations. This work proposes the OmniLens++ framework, which resolves two challenges that hinder the generalization ability of existing pipelines: the difficulty of scaling data and the absence of prior guidance characterizing optical degradation. To improve data scalability, we expand the design specifications to increase the degradation diversity of the lens source, and we sample a more uniform distribution by quantifying the spatial-variation patterns and severity of optical degradation. In terms of model design, to leverage the Point Spread Functions (PSFs), which intuitively describe optical degradation, as guidance in a blind paradigm, we propose the Latent PSF Representation (LPR). The VQVAE framework is introduced to learn latent features of LensLib's PSFs, which is assisted by modeling the optical degradation process to constrain the learning of degradation priors. Experiments on diverse aberrations of real-world lenses and synthetic LensLib show that OmniLens++ exhibits state-of-the-art generalization capacity in blind aberration correction. Beyond performance, the AODLibpro is verified as a scalable foundation for more effective training across diverse aberrations, and LPR can further tap the potential of large-scale LensLib. The source code and datasets will be made publicly available at https://github.com/zju-jiangqi/OmniLens2.

Zongxi Yu, Xiaolong Qian, Shaohua Gao et al.

Achieving high-fidelity, compact RGBD imaging presents a dual challenge: conventional compact optics struggle with RGB sharpness across the entire depth-of-field, while software-only Monocular Depth Estimation (MDE) is an ill-posed problem reliant on unreliable semantic priors. While deep optics with elements like DOEs can encode depth, they introduce trade-offs in fabrication complexity and chromatic aberrations, compromising simplicity. To address this, we first introduce a novel bio-inspired all-spherical monocentric lens, around which we build the Bionic Monocentric Imaging (BMI) framework, a holistic co-design. This optical design naturally encodes depth into its depth-varying Point Spread Functions (PSFs) without requiring complex diffractive or freeform elements. We establish a rigorous physically-based forward model to generate a synthetic dataset by precisely simulating the optical degradation process. This simulation pipeline is co-designed with a dual-head, multi-scale reconstruction network that employs a shared encoder to jointly recover a high-fidelity All-in-Focus (AiF) image and a precise depth map from a single coded capture. Extensive experiments validate the state-of-the-art performance of the proposed framework. In depth estimation, the method attains an Abs Rel of 0.026 and an RMSE of 0.130, markedly outperforming leading software-only approaches and other deep optics systems. For image restoration, the system achieves an SSIM of 0.960 and a perceptual LPIPS score of 0.082, thereby confirming a superior balance between image fidelity and depth accuracy. This study illustrates that the integration of bio-inspired, fully spherical optics with a joint reconstruction algorithm constitutes an effective strategy for addressing the intrinsic challenges in high-performance compact RGBD imaging. Source code will be publicly available at https://github.com/ZongxiYu-ZJU/BMI.

Yao Gao, Lei Sun, Shaohua Gao et al.

The highly non-convex optimization landscape of modern lens design necessitates extensive human expertise, resulting in inefficiency and constrained design diversity. While automated methods are desirable, existing approaches remain limited to simple tasks or produce complex lenses with suboptimal image quality. Drawing inspiration from the synaptic pruning mechanism in mammalian neural development, this study proposes OptiNeuro--a novel automated lens design framework that first generates diverse initial structures and then progressively eliminates low-performance lenses while refining remaining candidates through gradient-based optimization. By fully automating the design of complex aspheric imaging lenses, OptiNeuro demonstrates quasi-human-level performance, identifying multiple viable candidates with minimal human intervention. This advancement not only enhances the automation level and efficiency of lens design but also facilitates the exploration of previously uncharted lens architectures.