Hamidreza Jamalabadi

Lukas Fisch, Nils R. Winter, Janik Goltermann et al.

Voxel-based Morphometry (VBM) has emerged as a powerful approach in neuroimaging research, utilized in over 7,000 studies since the year 2000. Using Magnetic Resonance Imaging (MRI) data, VBM assesses variations in the local density of brain tissue and examines its associations with biological and psychometric variables. Here, we present deepmriprep, a neural network-based pipeline that performs all necessary preprocessing steps for VBM analysis of T1-weighted MR images using deep neural networks. Utilizing the Graphics Processing Unit (GPU), deepmriprep is 37 times faster than CAT12, the leading VBM preprocessing toolbox. The proposed method matches CAT12 in accuracy for tissue segmentation and image registration across more than 100 datasets and shows strong correlations in VBM results. Tissue segmentation maps from deepmriprep have over 95% agreement with ground truth maps, and its non-linear registration, using supervised SYMNet, predicts smooth deformation fields comparable to CAT12. The high processing speed of deepmriprep enables rapid preprocessing of extensive datasets and thereby fosters the application of VBM analysis to large-scale neuroimaging studies and opens the door to real-time applications. Finally, deepmripreps straightforward, modular design enables researchers to easily understand, reuse, and advance the underlying methods, fostering further advancements in neuroimaging research. deepmriprep can be conveniently installed as a Python package and is publicly accessible at https://github.com/wwu-mmll/deepmriprep.

Hiba Arnaout, Anmol Goel, H. Andrew Schwartz et al.

Although artificial intelligence (AI) shows growing promise for mental health care, current approaches to evaluating AI tools in this domain remain fragmented and poorly aligned with clinical practice, social context, and first-hand user experience. This paper argues for a rethinking of responsible evaluation -- what is measured, by whom, and for what purpose -- by introducing an interdisciplinary framework that integrates clinical soundness, social context, and equity, providing a structured basis for evaluation. Through an analysis of 135 recent *CL publications, we identify recurring limitations, including over-reliance on generic metrics that do not capture clinical validity, therapeutic appropriateness, or user experience, limited participation from mental health professionals, and insufficient attention to safety and equity. To address these gaps, we propose a taxonomy of AI mental health support types -- assessment-, intervention-, and information synthesis-oriented -- each with distinct risks and evaluative requirements, and illustrate its use through case studies.

Darya Hryhoryeva, Amaia Zurinaga, Hamidreza Jamalabadi et al.

This paper presents our system developed for SemEval-2026 Task 2. The task requires modeling both current affect and short-term affective change in chronologically ordered user-generated texts. We explore three complementary approaches: (1) LLM prompting under user-aware and user-agnostic settings, (2) a pairwise Maximum Entropy (MaxEnt) model with Ising-style interactions for structured transition modeling, and (3) a lightweight neural regression model incorporating recent affective trajectories and trainable user embeddings. Our findings indicate that LLMs effectively capture static affective signals from text, whereas short-term affective variation in this dataset is more strongly explained by recent numeric state trajectories than by textual semantics. Our system ranked first among participating teams in both Subtask 1 and Subtask 2A based on the official evaluation metric.

Doan Nam Long Vu, Rui Tan, Lena Moench et al.

The development of AI for mental health is hindered by a lack of authentic therapy dialogues, due to strict privacy regulations and the fact that clinical sessions were historically rarely recorded. We present an LLM-driven pipeline that generates synthetic counseling dialogues based on structured client profiles and psychological questionnaires. Grounded on the principles of Cognitive Behavioral Therapy (CBT), our method creates synthetic therapeutic conversations for clinical disorders such as anxiety and depression. Our framework, SQPsych (Structured Questionnaire-based Psychotherapy), converts structured psychological input into natural language dialogues through therapist-client simulations. Due to data governance policies and privacy restrictions prohibiting the transmission of clinical questionnaire data to third-party services, previous methodologies relying on proprietary models are infeasible in our setting. We address this limitation by generating a high-quality corpus using open-weight LLMs, validated through human expert evaluation and LLM-based assessments. Our SQPsychLLM models fine-tuned on SQPsychConv achieve strong performance on counseling benchmarks, surpassing baselines in key therapeutic skills. Our findings highlight the potential of synthetic data to enable scalable, data-secure, and clinically informed AI for mental health support. We will release our code, models, and corpus at https://ai-mh.github.io/SQPsych