Vinti Agarwal

Chinmay Nema, Hari Om Aggrawal, Dipam Goswami et al.

Microscopic urinalysis is a routine diagnostic test at hospitals. Recent studies have demonstrated the effectiveness of deep learning methods to automate microscopic urinalysis. These methods rely on high-quality images of the urine samples in which each cell is clearly identifiable. However, in practice, the urine sample on a glass slide has a multi-layer structure; hence, all the cells are not clearly visible within the depth of field of a lens focused at a particular focal plane. It demands acquiring multiple images at different focal planes to correctly identify each cell in a given urine sample, which is a time-consuming task. In this paper, we propose to simplify the task by recording a video, in place of acquiring multiple images, while gradually changing the focus of the lens manually by hand. A typical length of the video is from 2 to 14 seconds. We reconstruct an all-in-focus image from the recorded video frames and apply a deep learning model to detect and classify urine sediments. As a proof of concept, we conduct experiments on 14 videos acquired by a trained lab technician in a usual diagnostic lab environment and show the effectiveness of the proposed automated urinalysis pipeline with our novel reconstruction algorithm.

Chaarvi Bansal, Rohitash Chandra, Vinti Agarwal et al.

Drug repurposing (or repositioning) is the process of finding new therapeutic uses for drugs already approved by drug regulatory authorities (e.g., the Food and Drug Administration (FDA) and Therapeutic Goods Administration (TGA)) for other diseases. This involves analyzing the interactions between different biological entities, such as drug targets (genes/proteins and biological pathways) and drug properties, to discover novel drug-target or drug-disease relations. Artificial intelligence methods such as machine learning and deep learning have successfully analyzed complex heterogeneous data in the biomedical domain and have also been used for drug repurposing. This study presents a novel unsupervised machine learning framework that utilizes a graph-based autoencoder for multi-feature type clustering on heterogeneous drug data. The dataset consists of 438 drugs, of which 224 are under clinical trials for COVID-19 (category A). The rest are systematically filtered to ensure the safety and efficacy of the treatment (category B). The framework solely relies on reported drug data, including its pharmacological properties, chemical/physical properties, interaction with the host, and efficacy in different publicly available COVID-19 assays. Our machine-learning framework reveals three clusters of interest and provides recommendations featuring the top 15 drugs for COVID-19 drug repurposing, which were shortlisted based on the predicted clusters that were dominated by category A drugs. The anti-COVID efficacy of the drugs should be verified by experimental studies. Our framework can be extended to support other datasets and drug repurposing studies, given open-source code and data availability.

Hari Om Aggrawal, Dipam Goswami, Vinti Agarwal

The size of an individual cell type, such as a red blood cell, does not vary much among humans. We use this knowledge as a prior for classifying and detecting cells in images with only a few ground truth bounding box annotations, while most of the cells are annotated with points. This setting leads to weakly semi-supervised learning. We propose replacing points with either stochastic (ST) boxes or bounding box predictions during the training process. The proposed "mean-IOU" ST box maximizes the overlap with all the boxes belonging to the sample space with a class-specific approximated prior probability distribution of bounding boxes. Our method trains with both box- and point-labelled images in conjunction, unlike the existing methods, which train first with box- and then point-labelled images. In the most challenging setting, when only 5% images are box-labelled, quantitative experiments on a urine dataset show that our one-stage method outperforms two-stage methods by 5.56 mAP. Furthermore, we suggest an approach that partially answers "how many box-labelled annotations are necessary?" before training a machine learning model.

Tanay Sodha, Aditya Sharma, Ramya Hebbalaguppe et al.

Reliable confidence estimation remains a key limitation of test-time adaptation in vision-language models (VLMs), where prompt tuning improves zero-shot accuracy but often degrades calibration due to entropy-driven overconfidence. Prior approaches mitigate this using LLM-derived class attributes and contrastive regularization, yet treat attributes independently, ignoring their relational structure. We propose ARGTCA, which represents (class, attribute) pairs as nodes in a Symbolic Attribute Graph and trains a Graph Attention Network (GAT) using contrastive objectives to produce structurally informed embeddings that capture inter-attribute dependencies. We introduce two attribute selection strategies: ARGTCA-DIV for intra-class diversity and ARGTCA-DISC for inter-class discrimination. Experiments across nine benchmarks show that ARGTCA-DIV reduces average Expected Calibration Error (ECE) by approximately ~37% over baselines, while ARGTCA-DISC consistently performs as the second-best variant, reducing average ECE by approximately ~17% over baselines. These results suggest that modeling symbolic attribute interactions provides a principled approach for reliable test-time adaptation in VLMs.

Apoorva Gulati, Rajesh Kumar, Vinti Agarwal et al.

Large Language Models (LLMs) have made it easier to create realistic fake profiles on platforms like LinkedIn. This poses a significant risk for text-based fake profile detectors. In this study, we evaluate the robustness of existing detectors against LLM-generated profiles. While highly effective in detecting manually created fake profiles (False Accept Rate: 6-7%), the existing detectors fail to identify GPT-generated profiles (False Accept Rate: 42-52%). We propose GPT-assisted adversarial training as a countermeasure, restoring the False Accept Rate to between 1-7% without impacting the False Reject Rates (0.5-2%). Ablation studies revealed that detectors trained on combined numerical and textual embeddings exhibit the highest robustness, followed by those using numerical-only embeddings, and lastly those using textual-only embeddings. Complementary analysis on the ability of prompt-based GPT-4Turbo and human evaluators affirms the need for robust automated detectors such as the one proposed in this study.

Dipam Goswami, Hari Om Aggrawal, Rajiv Gupta et al.

Urinalysis is a standard diagnostic test to detect urinary system related problems. The automation of urinalysis will reduce the overall diagnostic time. Recent studies used urine microscopic datasets for designing deep learning based algorithms to classify and detect urine cells. But these datasets are not publicly available for further research. To alleviate the need for urine datsets, we prepare our urine sediment microscopic image (UMID) dataset comprising of around 3700 cell annotations and 3 categories of cells namely RBC, pus and epithelial cells. We discuss the several challenges involved in preparing the dataset and the annotations. We make the dataset publicly available.