Liang Tian

Liang Tian, Chengzhi Zhang

COVID-19 has had a profound impact on the lives of all human beings. Emerging technologies have made significant contributions to the fight against the pandemic. An extensive review of the application of technology will help facilitate future research and technology development to provide better solutions for future pandemics. In contrast to the extensive surveys of academic communities that have already been conducted, this study explores the IT community of practice. Using GitHub as the study target, we analyzed the main functionalities of the projects submitted during the pandemic. This study examines trends in projects with different functionalities and the relationship between functionalities and technologies. The study results show an imbalance in the number of projects with varying functionalities in the GitHub community, i.e., applications account for more than half of the projects. In contrast, other data analysis and AI projects account for a smaller share. This differs significantly from the survey of the academic community, where the findings focus more on cutting-edge technologies while projects in the community of practice use more mature technologies. The spontaneous behavior of developers may lack organization and make it challenging to target needs.

Haoran Li, Xingye Cheng, Ziyang Huang et al.

Traditional Chinese Medicine diagnosis and treatment principles, established through centuries of trial-and-error clinical practice, directly maps patient-specific symptom patterns to personalised herbal therapies. These empirical holistic mapping principles offer valuable strategies to address remaining challenges of reductionism methodologies in modern biomedicine. However, the lack of a quantitative framework and molecular-level evidence has limited their interpretability and reliability. Here, we present an AI framework trained on ancient and classical TCM formula records to quantify the symptom pattern-herbal therapy mappings. Interestingly, we find that empirical TCM diagnosis and treatment are consistent with the encoding-decoding processes in the AI model. This enables us to construct an interpretable TCM embedding space (TCM-ES) using the model's quantitative representation of TCM principles. Validated through broad and extensive TCM patient data, the TCM-ES offers universal quantification of the TCM practice and therapeutic efficacy. We further map biomedical entities into the TCM-ES through correspondence alignment. We find that the principal directions of the TCM-ES are significantly associated with key biological functions (such as metabolism, immune, and homeostasis), and that the disease and herb embedding proximity aligns with their genetic relationships in the human protein interactome, which demonstrate the biological significance of TCM principles. Moreover, the TCM-ES uncovers latent disease relationships, and provides alternative metric to assess clinical efficacy for modern disease-drug pairs. Finally, we construct a comprehensive and integrative TCM knowledge graph, which predicts potential associations between diseases and targets, drugs, herbal compounds, and herbal therapies, providing TCM-informed opportunities for disease analysis and drug development.