Wenjun Ma

Jia Wei, Yun Li, Xiaomao Fan et al.

Laryngo-pharyngeal cancer (LPC) is a highly lethal malignancy in the head and neck region. Recent advancements in tumor detection, particularly through dual-branch network architectures, have significantly improved diagnostic accuracy by integrating global and local feature extraction. However, challenges remain in accurately localizing lesions and fully capitalizing on the complementary nature of features within these branches. To address these issues, we propose SAM-Swin, an innovative SAM-driven Dual-Swin Transformer for laryngo-pharyngeal tumor detection. This model leverages the robust segmentation capabilities of the Segment Anything Model 2 (SAM2) to achieve precise lesion segmentation. Meanwhile, we present a multi-scale lesion-aware enhancement module (MS-LAEM) designed to adaptively enhance the learning of nuanced complementary features across various scales, improving the quality of feature extraction and representation. Furthermore, we implement a multi-scale class-aware guidance (CAG) loss that delivers multi-scale targeted supervision, thereby enhancing the model's capacity to extract class-specific features. To validate our approach, we compiled three LPC datasets from the First Affiliated Hospital (FAHSYSU), the Sixth Affiliated Hospital (SAHSYSU) of Sun Yat-sen University, and Nanfang Hospital of Southern Medical University (NHSMU). The FAHSYSU dataset is utilized for internal training, while the SAHSYSU and NHSMU datasets serve for external evaluation. Extensive experiments demonstrate that SAM-Swin outperforms state-of-the-art methods, showcasing its potential for advancing LPC detection and improving patient outcomes. The source code of SAM-Swin is available at the URL of \href{https://github.com/VVJia/SAM-Swin}{https://github.com/VVJia/SAM-Swin}.

Hang Yuan, Chen Li, Wenjun Ma et al.

Hit-like molecular generation with therapeutic potential is essential for target-specific drug discovery. However, the field lacks heterogeneous data and unified frameworks for integrating diverse molecular representations. To bridge this gap, we introduce TextOmics, a pioneering benchmark that establishes one-to-one correspondences between omics expressions and molecular textual descriptions. TextOmics provides a heterogeneous dataset that facilitates molecular generation through representations alignment. Built upon this foundation, we propose ToDi, a generative framework that jointly conditions on omics expressions and molecular textual descriptions to produce biologically relevant, chemically valid, hit-like molecules. ToDi leverages two encoders (OmicsEn and TextEn) to capture multi-level biological and semantic associations, and develops conditional diffusion (DiffGen) for controllable generation. Extensive experiments confirm the effectiveness of TextOmics and demonstrate ToDi outperforms existing state-of-the-art approaches, while also showcasing remarkable potential in zero-shot therapeutic molecular generation. Sources are available at: https://github.com/hala-ToDi.