Nicolas Känzig

Ioannis Gatopoulos, Nicolas Känzig, Sebastian Otálora et al.

Self-supervised learning has enabled large-scale pre-training on 2D natural images, producing general-purpose visual representations that transfer effectively across tasks. However, many medical imaging modalities, such as CT scans, are inherently three-dimensional and differ fundamentally from natural images in both structure and semantics. Volumetric modalities capture spatial continuity, organ anatomy, and intensity-based tissue properties (e.g., Hounsfield Units), which are not adequately modeled by 2D pre-training. To bridge this gap, we introduce CoralBay, a self-distillation framework that extends DINO by using a hierarchical 3D Swin backbone and applying self-distillation to concatenated multi-scale features, enabling data-efficient self-supervised learning of rich spatial representations that encode both global semantics and fine-grained local structure. As a result, CoralBay transfers effectively to a wide range of downstream radiological tasks, demonstrating strong and consistent performance across diverse anatomical targets. In addition, we contribute to the open-source \eva framework by introducing a public, reproducible 3D radiology leaderboard that unifies multiple datasets and establishes a standardized benchmark for evaluating volumetric representation learning methods.

kaiko. ai, Nanne Aben, Edwin D. de Jong et al. · eth-zurich

Driven by the recent advances in deep learning methods and, in particular, by the development of modern self-supervised learning algorithms, increased interest and efforts have been devoted to build foundation models (FMs) for medical images. In this work, we present our scalable training pipeline for large pathology imaging data, and a comprehensive analysis of various hyperparameter choices and training techniques for building pathology FMs. We release and make publicly available the first batch of our pathology FMs (https://github.com/kaiko-ai/towards_large_pathology_fms) trained on open-access TCGA whole slide images, a commonly used collection of pathology images. The experimental evaluation shows that our models reach state-of-the-art performance on various patch-level downstream tasks, ranging from breast cancer subtyping to colorectal nuclear segmentation. Finally, to unify the evaluation approaches used in the field and to simplify future comparisons of different FMs, we present an open-source framework (https://github.com/kaiko-ai/eva) designed for the consistent evaluation of pathology FMs across various downstream tasks.

Mikhail Karasikov, Joost van Doorn, Nicolas Känzig et al. · eth-zurich

The field of computational pathology has recently seen rapid advances driven by the development of modern vision foundation models (FMs), typically trained on vast collections of pathology images. Recent studies demonstrate that increasing the training data set and model size and integrating domain-specific image processing techniques can significantly enhance the model's performance on downstream tasks. Building on these insights, our work incorporates several recent modifications to the standard DINOv2 framework from the literature to optimize the training of pathology FMs. We also apply a post-training procedure for fine-tuning models on higher-resolution images to further enrich the information encoded in the embeddings. We present three novel pathology FMs trained on up to two orders of magnitude fewer WSIs than those used to train other state-of-the-art FMs while demonstrating a comparable or superior performance on downstream tasks. Even the model trained on TCGA alone (12k WSIs) outperforms most existing FMs and, on average, matches Virchow2, the second-best FM published to date. This suggests that there still remains a significant potential for further improving the models and algorithms used to train pathology FMs to take full advantage of the vast data collections.

Bodo Rückauer, Nicolas Känzig, Shih-Chii Liu et al.

Mobile and embedded applications require neural networks-based pattern recognition systems to perform well under a tight computational budget. In contrast to commonly used synchronous, frame-based vision systems and CNNs, asynchronous, spiking neural networks driven by event-based visual input respond with low latency to sparse, salient features in the input, leading to high efficiency at run-time. The discrete nature of the event-based data streams makes direct training of asynchronous neural networks challenging. This paper studies asynchronous spiking neural networks, obtained by conversion from a conventional CNN trained on frame-based data. As an example, we consider a CNN trained to steer a robot to follow a moving target. We identify possible pitfalls of the conversion and demonstrate how the proposed solutions bring the classification accuracy of the asynchronous network to only 3\% below the performance of the original synchronous CNN, while requiring 12x fewer computations. While being applied to a simple task, this work is an important step towards low-power, fast, and embedded neural networks-based vision solutions for robotic applications.