Pedro Ferreira

Michael Tanzer, Pedro Ferreira, Andrew Scott et al.

Diffusion Tensor Cardiac Magnetic Resonance (DT-CMR) enables us to probe the microstructural arrangement of cardiomyocytes within the myocardium in vivo and non-invasively, which no other imaging modality allows. This innovative technology could revolutionise the ability to perform cardiac clinical diagnosis, risk stratification, prognosis and therapy follow-up. However, DT-CMR is currently inefficient with over six minutes needed to acquire a single 2D static image. Therefore, DT-CMR is currently confined to research but not used clinically. We propose to reduce the number of repetitions needed to produce DT-CMR datasets and subsequently de-noise them, decreasing the acquisition time by a linear factor while maintaining acceptable image quality. Our proposed approach, based on Generative Adversarial Networks, Vision Transformers, and Ensemble Learning, performs significantly and considerably better than previous proposed approaches, bringing single breath-hold DT-CMR closer to reality.

Yinzhe Wu, Jiahao Huang, Fanwen Wang et al.

Diffusion Tensor Cardiac Magnetic Resonance (DT-CMR) is the only in vivo method to non-invasively examine the microstructure of the human heart. Current research in DT-CMR aims to improve the understanding of how the cardiac microstructure relates to the macroscopic function of the healthy heart as well as how microstructural dysfunction contributes to disease. To get the final DT-CMR metrics, we need to acquire diffusion weighted images of at least 6 directions. However, due to DWI's low signal-to-noise ratio, the standard voxel size is quite big on the scale for microstructures. In this study, we explored the potential of deep-learning-based methods in improving the image quality volumetrically (x4 in all dimensions). This study proposed a novel framework to enable volumetric super-resolution, with an additional model input of high-resolution b0 DWI. We demonstrated that the additional input could offer higher super-resolved image quality. Going beyond, the model is also able to super-resolve DWIs of unseen b-values, proving the model framework's generalizability for cardiac DWI superresolution. In conclusion, we would then recommend giving the model a high-resolution reference image as an additional input to the low-resolution image for training and inference to guide all super-resolution frameworks for parametric imaging where a reference image is available.

Felix Anand Epp, Matti Nelimarkka, Jesse Haapoja et al.

This is the Proceedings of the First CHI Workshop on CHIdeology: Disentangling the fragmented politics, values, and imaginaries of Human-Computer Interaction through ideologies, held on Wednesday, 15 April, in Barcelona, Spain, at the ACM CHI Conference on Human Factors in Computing Systems.

Pedro Ferreira, Ivan Titov, Wilker Aziz

Explanation regularisation (ER) has been introduced as a way to guide text classifiers to form their predictions relying on input tokens that humans consider plausible. This is achieved by introducing an auxiliary explanation loss that measures how well the output of an input attribution technique for the model agrees with human-annotated rationales. The guidance appears to benefit performance in out-of-domain (OOD) settings, presumably due to an increased reliance on "plausible" tokens. However, previous work has under-explored the impact of guidance on that reliance, particularly when reliance is measured using attribution techniques different from those used to guide the model. In this work, we seek to close this gap, and also explore the relationship between reliance on plausible features and OOD performance. We find that the connection between ER and the ability of a classifier to rely on plausible features has been overstated and that a stronger reliance on plausible tokens does not seem to be the cause for OOD improvements.

Pedro Ferreira, Wilker Aziz, Ivan Titov

Chain-of-thought explanations are widely used to inspect the decision process of large language models (LLMs) and to evaluate the trustworthiness of model outputs, making them important for effective collaboration between LLMs and humans. We demonstrate that preference optimization - a key step in the alignment phase - can inadvertently reduce the faithfulness of these explanations. This occurs because the reward model (RM), which guides alignment, is tasked with optimizing both the expected quality of the response and the appropriateness of the explanations (e.g., minimizing bias or adhering to safety standards), creating potential conflicts. The RM lacks a mechanism to assess the consistency between the model's internal decision process and the generated explanation. Consequently, the LLM may engage in "reward hacking" by producing a final response that scores highly while giving an explanation tailored to maximize reward rather than accurately reflecting its reasoning. To address this issue, we propose enriching the RM's input with a causal attribution of the prediction, allowing the RM to detect discrepancies between the generated self-explanation and the model's decision process. In controlled settings, we show that this approach reduces the tendency of the LLM to generate misleading explanations.

Jo Schlemper, Guang Yang, Pedro Ferreira et al.

Understanding the structure of the heart at the microscopic scale of cardiomyocytes and their aggregates provides new insights into the mechanisms of heart disease and enables the investigation of effective therapeutics. Diffusion Tensor Cardiac Magnetic Resonance (DT-CMR) is a unique non-invasive technique that can resolve the microscopic structure, organisation, and integrity of the myocardium without the need for exogenous contrast agents. However, this technique suffers from relatively low signal-to-noise ratio (SNR) and frequent signal loss due to respiratory and cardiac motion. Current DT-CMR techniques rely on acquiring and averaging multiple signal acquisitions to improve the SNR. Moreover, in order to mitigate the influence of respiratory movement, patients are required to perform many breath holds which results in prolonged acquisition durations (e.g., ~30 mins using the existing technology). In this study, we propose a novel cascaded Convolutional Neural Networks (CNN) based compressive sensing (CS) technique and explore its applicability to improve DT-CMR acquisitions. Our simulation based studies have achieved high reconstruction fidelity and good agreement between DT-CMR parameters obtained with the proposed reconstruction and fully sampled ground truth. When compared to other state-of-the-art methods, our proposed deep cascaded CNN method and its stochastic variation demonstrated significant improvements. To the best of our knowledge, this is the first study using deep CNN based CS for the DT-CMR reconstruction. In addition, with relatively straightforward modifications to the acquisition scheme, our method can easily be translated into a method for online, at-the-scanner reconstruction enabling the deployment of accelerated DT-CMR in various clinical applications.

Chaitanya Malaviya, Pedro Ferreira, André F. T. Martins

In NMT, words are sometimes dropped from the source or generated repeatedly in the translation. We explore novel strategies to address the coverage problem that change only the attention transformation. Our approach allocates fertilities to source words, used to bound the attention each word can receive. We experiment with various sparse and constrained attention transformations and propose a new one, constrained sparsemax, shown to be differentiable and sparse. Empirical evaluation is provided in three languages pairs.

Ezilda Almeida, Pedro Ferreira, Tiago Vinhoza et al.

Bayesian network structures are usually built using only the data and starting from an empty network or from a naive Bayes structure. Very often, in some domains, like medicine, a prior structure knowledge is already known. This structure can be automatically or manually refined in search for better performance models. In this work, we take Bayesian networks built by specialists and show that minor perturbations to this original network can yield better classifiers with a very small computational cost, while maintaining most of the intended meaning of the original model.