Kyle Harrington

Ulrik Günther, Kyle I. S. Harrington, Raimund Dachselt et al.

We present Bionic Tracking, a novel method for solving biological cell tracking problems with eye tracking in virtual reality using commodity hardware. Using gaze data, and especially smooth pursuit eye movements, we are able to track cells in time series of 3D volumetric datasets. The problem of tracking cells is ubiquitous in developmental biology, where large volumetric microscopy datasets are acquired on a daily basis, often comprising hundreds or thousands of time points that span hours or days. The image data, however, is only a means to an end, and scientists are often interested in the reconstruction of cell trajectories and cell lineage trees. Reliably tracking cells in crowded three-dimensional space over many timepoints remains an open problem, and many current approaches rely on tedious manual annotation and curation. In our Bionic Tracking approach, we substitute the usual 2D point-and-click annotation to track cells with eye tracking in a virtual reality headset, where users simply have to follow a cell with their eyes in 3D space in order to track it. We detail the interaction design of our approach and explain the graph-based algorithm used to connect different time points, also taking occlusion and user distraction into account. We demonstrate our cell tracking method using the example of two different biological datasets. Finally, we report on a user study with seven cell tracking experts, demonstrating the benefits of our approach over manual point-and-click tracking.

Dennis G Wilson, Sylvain Cussat-Blanc, Hervé Luga et al.

In the brain, learning signals change over time and synaptic location, and are applied based on the learning history at the synapse, in the complex process of neuromodulation. Learning in artificial neural networks, on the other hand, is shaped by hyper-parameters set before learning starts, which remain static throughout learning, and which are uniform for the entire network. In this work, we propose a method of deep artificial neuromodulation which applies the concepts of biological neuromodulation to stochastic gradient descent. Evolved neuromodulatory dynamics modify learning parameters at each layer in a deep neural network over the course of the network's training. We show that the same neuromodulatory dynamics can be applied to different models and can scale to new problems not encountered during evolution. Finally, we examine the evolved neuromodulation, showing that evolution found dynamic, location-specific learning strategies.

Dennis G Wilson, Kyle Harrington, Sylvain Cussat-Blanc et al.

Over the past twenty years, artificial Gene Regulatory Networks (GRNs) have shown their capacity to solve real-world problems in various domains such as agent control, signal processing and artificial life experiments. They have also benefited from new evolutionary approaches and improvements to dynamic which have increased their optimization efficiency. In this paper, we present an additional step toward their usability in machine learning applications. We detail an GPU-based implementation of differentiable GRNs, allowing for local optimization of GRN architectures with stochastic gradient descent (SGD). Using a standard machine learning dataset, we evaluate the ways in which evolution and SGD can be combined to further GRN optimization. We compare these approaches with neural network models trained by SGD and with support vector machines.