Hua Jin

Kanxue Li, Yibing Zhan, Hua Jin et al.

Intraoperative hypotension (IOH) poses significant surgical risks, but accurate prediction remains challenging due to patient-specific variability. While test-time adaptation (TTA) offers a promising approach for personalized prediction, the rarity of IOH events often leads to unreliable test-time training. To address this, we propose CSA-TTA, a novel Cross-Sample Augmented Test-Time Adaptation framework that enhances training by incorporating hypotension events from other individuals. Specifically, we first construct a cross-sample bank by segmenting historical data into hypotensive and non-hypotensive samples. Then, we introduce a coarse-to-fine retrieval strategy for building test-time training data: we initially apply K-Shape clustering to identify representative cluster centers and subsequently retrieve the top-K semantically similar samples based on the current patient signal. Additionally, we integrate both self-supervised masked reconstruction and retrospective sequence forecasting signals during training to enhance model adaptability to rapid and subtle intraoperative dynamics. We evaluate the proposed CSA-TTA on both the VitalDB dataset and a real-world in-hospital dataset by integrating it with state-of-the-art time series forecasting models, including TimesFM and UniTS. CSA-TTA consistently enhances performance across settings-for instance, on VitalDB, it improves Recall and F1 scores by +1.33% and +1.13%, respectively, under fine-tuning, and by +7.46% and +5.07% in zero-shot scenarios-demonstrating strong robustness and generalization.

Wanyin Wu, Kanxue Li, Baosheng Yu et al.

Accurate prediction of surgical duration is pivotal for hospital resource management. Although recent supervised learning approaches-from machine learning (ML) to fine-tuned large language models (LLMs)-have shown strong performance, they remain constrained by the need for high-quality labeled data and computationally intensive training. In contrast, zero-shot LLM inference offers a promising training-free alternative but it lacks grounding in institution-specific clinical context (e.g., local demographics and case-mix distributions), making its predictions clinically misaligned and prone to instability. To address these limitations, we present PREBA, a retrieval-augmented framework that integrates PCA-weighted retrieval and Bayesian averaging aggregation to ground LLM predictions in institution-specific clinical evidence and statistical priors. The core of PREBA is to construct an evidence-based prompt for the LLM, comprising (1) the most clinically similar historical surgical cases and (2) clinical statistical priors. To achieve this, PREBA first encodes heterogeneous clinical features into a unified representation space enabling systematic retrieval. It then performs PCA-weighted retrieval to identify clinically relevant historical cases, which form the evidence context supplied to the LLM. Finally, PREBA applies Bayesian averaging to fuse multi-round LLM predictions with population-level statistical priors, yielding calibrated and clinically plausible duration estimates. We evaluate PREBA on two real-world clinical datasets using three state-of-the-art LLMs, including Qwen3, DeepSeek-R1, and HuatuoGPT-o1. PREBA significantly improves performance-for instance, reducing MAE by up to 40% and raising R^2 from -0.13 to 0.62 over zero-shot inference-and it achieves accuracy competitive with supervised ML methods, demonstrating strong effectiveness and generalization.

Xiang Feng, Wentao Jiang, Zengmao Wang et al.

The application of large language models (LLMs) in the medical field has garnered significant attention, yet their reasoning capabilities in more specialized domains like anesthesiology remain underexplored. To bridge this gap, we introduce AnesSuite, the first comprehensive dataset suite specifically designed for anesthesiology reasoning in LLMs. The suite features AnesBench, an evaluation benchmark tailored to assess anesthesiology-related reasoning across three levels: factual retrieval (System 1), hybrid reasoning (System 1.x), and complex decision-making (System 2). Alongside this benchmark, the suite includes three training datasets that provide an infrastructure for continued pre-training (CPT), supervised fine-tuning (SFT), and reinforcement learning with verifiable rewards (RLVR). Leveraging this suite, we develop Morpheus, the first baseline model collection for anesthesiology reasoning. Despite undergoing limited training with SFT and group relative policy optimization (GRPO), Morpheus demonstrates substantial performance improvements, rivaling the performance of larger-scale models. Furthermore, through comprehensive evaluations and experiments, we analyze the key factors influencing anesthesiology reasoning performance, including model characteristics, training strategies and training data. Both AnesSuite and Morpheus will be open-sourced at https://github.com/MiliLab/AnesSuite.

Juhua Liu, Qihuang Zhong, Liang Ding et al.

Aspect-based Sentiment Analysis (ABSA) aims to determine the sentiment polarity towards an aspect. Because of the expensive and limited labelled data, the pretraining strategy has become the de-facto standard for ABSA. However, there always exists severe domain shift between the pretraining and downstream ABSA datasets, hindering the effective knowledge transfer when directly finetuning and making the downstream task performs sub-optimal. To mitigate such domain shift, we introduce a unified alignment pretraining framework into the vanilla pretrain-finetune pipeline with both instance- and knowledge-level alignments. Specifically, we first devise a novel coarse-to-fine retrieval sampling approach to select target domain-related instances from the large-scale pretraining dataset, thus aligning the instances between pretraining and target domains (First Stage). Then, we introduce a knowledge guidance-based strategy to further bridge the domain gap at the knowledge level. In practice, we formulate the model pretrained on the sampled instances into a knowledge guidance model and a learner model, respectively. On the target dataset, we design an on-the-fly teacher-student joint fine-tuning approach to progressively transfer the knowledge from the knowledge guidance model to the learner model (Second Stage). Thereby, the learner model can maintain more domain-invariant knowledge when learning new knowledge from the target dataset. In the Third Stage, the learner model is finetuned to better adapt its learned knowledge to the target dataset. Extensive experiments and analyses on several ABSA benchmarks demonstrate the effectiveness and universality of our proposed pretraining framework. Our source code and models are publicly available at https://github.com/WHU-ZQH/UIKA.

Zhonghai Wang, Jie Jiang, Yibing Zhan et al.

Medical large language models (LLMs) have gained popularity recently due to their significant practical utility. However, most existing research focuses on general medicine, and there is a need for in-depth study of LLMs in specific fields like anesthesiology. To fill the gap, we introduce Hypnos, a Chinese Anesthesia model built upon existing LLMs, e.g., Llama. Hypnos' contributions have three aspects: 1) The data, such as utilizing Self-Instruct, acquired from current LLMs likely includes inaccuracies. Hypnos implements a cross-filtering strategy to improve the data quality. This strategy involves using one LLM to assess the quality of the generated data from another LLM and filtering out the data with low quality. 2) Hypnos employs a general-to-specific training strategy that starts by fine-tuning LLMs using the general medicine data and subsequently improving the fine-tuned LLMs using data specifically from Anesthesiology. The general medical data supplement the medical expertise in Anesthesiology and enhance the effectiveness of Hypnos' generation. 3) We introduce a standardized benchmark for evaluating medical LLM in Anesthesiology. Our benchmark includes both publicly available instances from the Internet and privately obtained cases from the Hospital. Hypnos outperforms other medical LLMs in anesthesiology in metrics, GPT-4, and human evaluation on the benchmark dataset.

Qihuang Zhong, Liang Ding, Juhua Liu et al.

Aspect-based sentiment analysis (ABSA) is a fine-grained task of sentiment analysis. To better comprehend long complicated sentences and obtain accurate aspect-specific information, linguistic and commonsense knowledge are generally required in this task. However, most current methods employ complicated and inefficient approaches to incorporate external knowledge, e.g., directly searching the graph nodes. Additionally, the complementarity between external knowledge and linguistic information has not been thoroughly studied. To this end, we propose a knowledge graph augmented network KGAN, which aims to effectively incorporate external knowledge with explicitly syntactic and contextual information. In particular, KGAN captures the sentiment feature representations from multiple different perspectives, i.e., context-, syntax- and knowledge-based. First, KGAN learns the contextual and syntactic representations in parallel to fully extract the semantic features. Then, KGAN integrates the knowledge graphs into the embedding space, based on which the aspect-specific knowledge representations are further obtained via an attention mechanism. Last, we propose a hierarchical fusion module to complement these multi-view representations in a local-to-global manner. Extensive experiments on five popular ABSA benchmarks demonstrate the effectiveness and robustness of our KGAN. Notably, with the help of the pretrained model of RoBERTa, KGAN achieves a new record of state-of-the-art performance among all datasets.